(Q36863174)

16 August 2017

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques (English)

1 reference

16 August 2017

0 references

0 references

10

Susan Gilfillan

0 references

Tyler K Ulland

Tyler K Ulland

2

0 references

Thomas E. Mahan

Thomas E Mahan

8

0 references

Marco Colonna

Marco Colonna

16

0 references

David M. Holtzman

15

David M Holtzman

1 reference

16 August 2017

12

Jaime Grutzendler

1 reference

16 August 2017

Yaming Wang

1

1 reference

16 August 2017

Jason D Ulrich

3

1 reference

16 August 2017

Wilbur Song

4

1 reference

16 August 2017

John A Tzaferis

5

1 reference

16 August 2017

Justin T Hole

6

1 reference

16 August 2017

Peng Yuan

7

1 reference

16 August 2017

Yang Shi

9

1 reference

16 August 2017

Marina Cella

11

1 reference

16 August 2017

Ronald B DeMattos

13

1 reference

16 August 2017

John R Cirrito

14

1 reference

16 August 2017

language of work or name

English

0 references

publication date

18 April 2016

1 reference

Journal of Experimental Medicine

16 August 2017

1 reference

16 August 2017

213

1 reference

16 August 2017

5

1 reference

16 August 2017

667-675

1 reference

Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Truncated and modified amyloid-beta species

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Alzheimer's disease risk genes and mechanisms of disease pathogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Identification of a unique TGF-β-dependent molecular and functional signature in microglia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

The genetics of Alzheimer disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Regulation of microglia development and homeostasis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Development and homeostasis of "resident" myeloid cells: the case of the microglia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Alzheimer's disease: the challenge of the second century

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Pattern recognition by TREM-2: binding of anionic ligands

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

TREM2 and Risk of Alzheimer's Disease--Friend or Foe?

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Specific lipid recognition is a general feature of CD300 and TREM molecules.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854736

Cutting Edge: TREM-2 Attenuates Macrophage Activation

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20151948

Genetics of Alzheimer's disease

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27091843

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27091843

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20151948

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

27091843

1 reference