(Q36871981)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17614759%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

review article

1 reference

title

Enviromimetics: exploring gene environment interactions to identify therapeutic targets for brain disorders (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17614759%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17614759%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

author name string

Caitlin E McOmish

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17614759%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

language of work or name

English

0 references

publication date

1 July 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17614759%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

1 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17614759%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17614759%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17614759%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

page(s)

899-913

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17614759%20AND%20SRC:MED&resulttype=core&format=json

Enriched environments, experience-dependent plasticity and disorders of the nervous system.

1 January 2020

cites work

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Novel therapeutic targets for Huntington's disease.

21 January 2018

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Delaying the onset of Huntington's in mice

21 January 2018

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Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism.

21 January 2018

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Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

21 January 2018

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ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.

21 January 2018

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Neural consequences of environmental enrichment

21 January 2018

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Effects of environmental enrichment on spatial memory and neurochemistry in middle-aged mice.

21 January 2018

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Increases in dendritic length in occipital cortex after 4 days of differential housing in weanling rats

21 January 2018

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Short exposure to an enriched environment accelerates plasticity in the barrel cortex of adult rats

21 January 2018

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Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins

21 January 2018

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Exploration of a novel environment leads to the expression of inducible transcription factors in barrel-related columns.

21 January 2018

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Transient and persistent dendritic spines in the neocortex in vivo

21 January 2018

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Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

21 January 2018

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Activity-dependent synaptogenesis in the adult Mammalian cortex

21 January 2018

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Rearing Complexity Affects Branching of Dendrites in the Visual Cortex of the Rat

21 January 2018

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Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory

21 January 2018

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Enhancement of hippocampal field potentials in rats exposed to a novel, complex environment.

21 January 2018

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Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo.

21 January 2018

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Running enhances neurogenesis, learning, and long-term potentiation in mice

21 January 2018

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Neurotrophins regulate dendritic growth in developing visual cortex

21 January 2018

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The yin and yang of neurotrophin action

21 January 2018

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Environmental influences on the central nervous system and their implications for the aging rat.

21 January 2018

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Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Acceleration of visual system development by environmental enrichment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Physical exercise induces FGF-2 and its mRNA in the hippocampus

21 January 2018

1 reference

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Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise

21 January 2018

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Environmental enrichment: effects on spatial memory and hippocampal CREB immunoreactivity.

21 January 2018

1 reference

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Environmental enrichment alters nerve growth factor-induced gene A and glucocorticoid receptor messenger RNA expression after middle cerebral artery occlusion in rats.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Complexity of sensory environment drives the expression of candidate-plasticity gene, nerve growth factor induced-A.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Partial reversal of the effect of maternal care on cognitive function through environmental enrichment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment and neurotransmitter receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Influences of environmental complexity and visual stimulation on development of occipital cortex in rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Effect of physical activity on hippocampal high affinity choline uptake and muscarinic binding: a comparison between young and old F344 rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment selectively increases 5-HT1A receptor mRNA expression and binding in the rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Glucocorticoid receptor and NGFI-A gene expression are induced in the hippocampus after environmental enrichment in adult rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental factors in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome.

21 January 2018

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Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

21 January 2018

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Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington's disease mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Decreased hippocampal cell proliferation in R6/1 Huntington's mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine.

21 January 2018

1 reference

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Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics

21 January 2018

1 reference

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Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease

21 January 2018

1 reference

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Participation in cognitively stimulating activities and risk of incident Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Influence of education and occupation on the incidence of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Brain reserve and dementia: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Alzheimer's disease. Play and exercise protect mouse brain from amyloid buildup.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Epidemiology of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Enriched environment improves motor function in intact and unilateral dopamine-depleted rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Therapeutic effects of environmental enrichment on cognitive function and tissue integrity following severe traumatic brain injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment and cortical injury: behavioral and anatomical consequences of frontal cortex lesions.

21 January 2018

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Postsurgical enrichment aids adult hemidecorticate rats on a spatial navigation task.

21 January 2018

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Gene expression profiling of the rat hippocampus one month after focal cerebral ischemia followed by enriched environment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental influences on functional outcome after a cortical infarct in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment reverses learning impairment in the Morris water maze after focal cerebral ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment attenuates cognitive deficits, but does not alter neurotrophin gene expression in the hippocampus following lateral fluid percussion brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment enhances recovery of function but exacerbates ischemic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Enriched environment increases neural stem/progenitor cell proliferation and neurogenesis in the subventricular zone of stroke-lesioned adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Neuronal plasticity and dendritic spines: effect of environmental enrichment on intact and postischemic rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Effects of cortical ischemia and postischemic environmental enrichment on hippocampal cell genesis and differentiation in the adult rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Impact of enriched-environment housing on brain-derived neurotrophic factor and on cognitive performance after a transient global ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Effects of postischemic environment on transcription factor and serotonin receptor expression after permanent focal cortical ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Gender and environmental enrichment impact dopamine transporter expression after experimental traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Genetic animal models: focus on schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Design of Potent Peptide Mimetics of Brain-derived Neurotrophic Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Enhanced N-methyl-D-aspartate function reverses working memory failure induced by blockade of group I metabotropic glutamate receptors in the rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Impaired visual memory in rats reared in isolation is reversed by D-cycloserine in the adult rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

D-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

A pilot study of D-cycloserine in subjects with autistic disorder

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Regulators of adult neurogenesis in the healthy and diseased brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Brain reserve and cognitive decline: a non-parametric systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

What is cognitive reserve? Theory and research application of the reserve concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Two-site enzyme immunoassay for beta NGF applied to human patient sera

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Neuroprotection in experimental stroke with targeted neurotrophins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Disruption of CREB function in brain leads to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Changes in the gene expression of GABA(A) receptor alpha1 and alpha2 subunits and metabotropic glutamate receptor 5 in the basal ganglia of the rats with unilateral 6-hydroxydopamine lesion and embryonic mesencephalic grafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Opiate receptor avidity and cerebral blood flow in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

An enriched environment increases noradrenaline concentration in the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

The role of norepinephrine in the pathophysiology of cognitive disorders: potential applications to the treatment of cognitive dysfunction in schizophrenia and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Molecular pathways to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

A proposed pathological model in the hippocampus of subjects with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

Role of glucocorticoids in dopamine-related neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.7.899

10.1517/14728222.11.7.899

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17614759%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference