(Q36877977)

16 August 2017

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title

3D structural information as a guide to protein engineering using genetic selection (English)

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16 August 2017

Kast P

1

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16 August 2017

Hilvert D

series ordinal

2

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16 August 2017

publication date

1 August 1997

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Current Opinion in Structural Biology

16 August 2017

published in

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16 August 2017

volume

7

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16 August 2017

issue

4

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16 August 2017

page(s)

470-479

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Engineering new functions and altering existing functions

16 August 2017

cites work

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7 January 2021

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7 January 2021

Protein design: the choice of de novo sequences

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7 January 2021

Protein folding from a combinatorial perspective

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7 January 2021

Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences

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7 January 2021

Stable, monomeric variants of lambda Cro obtained by insertion of a designed beta-hairpin sequence

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7 January 2021

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

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7 January 2021

Potential use of additivity of mutational effects in simplifying protein engineering

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7 January 2021

Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents

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7 January 2021

Selection of Streptomyces griseus protease B mutants with desired alterations in primary specificity using a library screening strategy

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7 January 2021

Selection of RNA-binding peptides in vivo

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7 January 2021

Core mutants of the immunoglobulin binding domain of streptococcal protein G: stability and structural integrity

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7 January 2021

Glubodies: randomized libraries of glutathione transferase enzymes

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7 January 2021

Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo

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7 January 2021

Mutational analysis of a transmembrane segment in a bacterial chemoreceptor

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7 January 2021

In vitro evolution of thermodynamically stable turns

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7 January 2021

Substitutions of Ser for Asn-163 and Pro for Leu-264 are important for stabilization of lipase from Pseudomonas aeruginosa

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7 January 2021

Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide

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7 January 2021

Phage display: protein engineering by directed evolution

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7 January 2021

Phage display of proteins

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7 January 2021

Selection of biologically active peptides by phage display of random peptide libraries

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7 January 2021

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7 January 2021

Role of capsid structure and membrane protein processing in determining the size and copy number of peptides displayed on the major coat protein of filamentous bacteriophage

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7 January 2021

Affinity maturation of phage-displayed peptide ligands

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7 January 2021

Phage display of proteases and macromolecular inhibitors

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7 January 2021

Screening of phage antibody libraries

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7 January 2021

A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

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7 January 2021

Construction and evolution of antibody-phage libraries by DNA shuffling

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7 January 2021

Applied evolution. The progeny of sexual PCR.

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7 January 2021

Coupling protein design and in vitro selection strategies: improving specificity and affinity of a designed beta-protein IL-6 antagonist

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7 January 2021

Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart

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7 January 2021

Selection of linkers for a catalytic single-chain antibody using phage display technology

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7 January 2021

Iterative optimization of high-affinity proteases inhibitors using phage display. 1. Plasmin

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7 January 2021

Iterative optimization of high-affinity protease inhibitors using phage display. 2. Plasma kallikrein and thrombin

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7 January 2021

A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

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https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Minimizing a binding domain from protein A.

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7 January 2021

Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase

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https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime

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7 January 2021

Amino acid sequence determinants of beta-lactamase structure and activity

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7 January 2021

Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria

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7 January 2021

Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis

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7 January 2021

Combinatorial mutagenesis and structural simulations in the environment of the redox-active tyrosine YZ of photosystem II.

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7 January 2021

A rapid screen of active site mutants in glycinamide ribonucleotide transformylase.

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7 January 2021

Structure prediction of the EcoRV DNA methyltransferase based on mutant profiling, secondary structure analysis, comparison with known structures of methyltransferases and isolation of catalytically inactive single mutants

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7 January 2021

Loop Replacement and Random Mutagenesis of -Loop D, Residues 7084, in Iso-1-cytochromec

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7 January 2021

Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure

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7 January 2021

In vivo selection of basic region-leucine zipper proteins with altered DNA-binding specificities

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https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Random mutagenesis targeted to the active site of the EcoRV restriction endonuclease

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7 January 2021

A genetic approach to the generation of antibodies with enhanced catalytic activities

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7 January 2021

Affinity selective isolation of ligands from peptide libraries through display on a lac repressor "headpiece dimer".

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7 January 2021

Chemical selection for catalysis in combinatorial antibody libraries

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https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

An in vitro polysome display system for identifying ligands from very large peptide libraries

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https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Cell-free synthesis of peptide libraries displayed on polysomes

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https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

In vitro selection and evolution of functional proteins by using ribosome display

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Site-Directed Mutagenesis with an Expanded Genetic Code

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Discrimination of a single base change in a ribozyme using the gene for dihydrofolate reductase as a selective marker in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

A novel genetic system to detect protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

The yeast two-hybrid system for studying protein-protein interactions

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https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Gene identification using the yeast two-hybrid system

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https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Genetic and biochemical probes for protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

A three-hybrid system for detecting small ligand-protein receptor interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

A three-hybrid system to detect RNA-protein interactions in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

A tri-hybrid system for the analysis and detection of RNA--protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system

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https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

The yeast two-hybrid system: forward and reverse

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https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Position and density effects on repression by stationary and mobile DNA-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

Genetic selection for genes encoding sequence-specific DNA-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980109-1

7 January 2021

10.1016/S0959-440X(97)80109-1

Identifiers

DOI

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16 August 2017

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