(Q36886861)

English

High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry

scientific article published on 25 August 2012

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scholarly article

1 reference

Europe PubMed Central

16 August 2017

High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry (English)

1 reference

Europe PubMed Central

16 August 2017

author name string

Fabio Cerignoli

1

1 reference

Europe PubMed Central

16 August 2017

David Charlot

2

1 reference

Europe PubMed Central

16 August 2017

Ross Whittaker

3

1 reference

Europe PubMed Central

16 August 2017

Randy Ingermanson

4

1 reference

Europe PubMed Central

16 August 2017

Piyush Gehalot

5

1 reference

Europe PubMed Central

16 August 2017

Alex Savchenko

6

1 reference

Europe PubMed Central

16 August 2017

David J Gallacher

7

1 reference

Europe PubMed Central

16 August 2017

Rob Towart

8

1 reference

Europe PubMed Central

16 August 2017

Jeffrey H Price

9

1 reference

Europe PubMed Central

16 August 2017

Patrick M McDonough

10

1 reference

Europe PubMed Central

16 August 2017

Mark Mercola

11

1 reference

Europe PubMed Central

16 August 2017

publication date

25 August 2012

1 reference

Europe PubMed Central

16 August 2017

Journal of Pharmacological and Toxicological Methods

1 reference

Europe PubMed Central

16 August 2017

66

1 reference

Europe PubMed Central

16 August 2017

3

1 reference

Europe PubMed Central

16 August 2017

246-256

1 reference

Europe PubMed Central

16 August 2017

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

1 reference

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Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

1 reference

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An update on nuclear calcium signalling.

1 reference

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Cardionomics: a new integrative approach for screening cardiotoxicity of drug candidates

1 reference

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Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening?

1 reference

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Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes

1 reference

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Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia

1 reference

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Use and abuse of QT and TRIaD in cardiac safety research: importance of study design and conduct

1 reference

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Calcium signaling

1 reference

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Inhibition of the cardiac L-type calcium channel current by antidepressant drugs.

1 reference

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The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities

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Preclinical cardiovascular risk assessment in modern drug development

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Analyzing proteome topology and function by automated multidimensional fluorescence microscopy

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Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends

1 reference

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Calcium release from ryanodine receptors in the nucleoplasmic reticulum

1 reference

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Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

1 reference

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Dynamic control of hERG/I(Kr) by PKA-mediated interactions with 14-3-3.

1 reference

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ICH S7B draft guideline on the non-clinical strategy for testing delayed cardiac repolarisation risk of drugs: a critical analysis

1 reference

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Techniques: high-throughput measurement of intracellular Ca(2+) -- back to basics.

1 reference

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Thyroid hormone action in the heart

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Arrhythmogenic mechanisms of QT prolonging drugs: is QT prolongation really the problem?

1 reference

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State-dependent trapping of flecainide in the cardiac sodium channel

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Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

1 reference

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29 September 2017

The impact of drug-induced QT interval prolongation on drug discovery and development

1 reference

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

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Drug-induced ventricular tachyarrhythmia in isolated rabbit hearts with atrioventricular block

1 reference

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Cardiac excitation-contraction coupling

1 reference

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Measurement of intracellular calcium

1 reference

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Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

1 reference

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Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride.

1 reference

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High affinity open channel block by dofetilide of HERG expressed in a human cell line.

1 reference

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Direct contact between sympathetic neurons and rat cardiac myocytes in vitro increases expression of functional calcium channels

1 reference

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The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block

1 reference

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27 June 2018

Doxorubicin cardiotoxicity: diastolic cardiac myocyte dysfunction as a result of impaired calcium handling in isolated cardiac myocytes

1 reference

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Role of Ca(2+)/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca(2+) current during endothelin-1 stimulation

1 reference

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4 September 2018

Altered cytosolic Ca2+ dynamics in cultured Guinea pig cardiomyocytes as an in vitro model to identify potential cardiotoxicants

1 reference

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Differential effects of phospholamban and Ca2+/calmodulin-dependent kinase II on [Ca2+]i transients in cardiac myocytes at physiological stimulation frequencies.

1 reference

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Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis

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Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.

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Drugs that induce repolarization abnormalities cause bradycardia in zebrafish

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Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-à-gogo K(+) channel

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Disruption of mitochondrial calcium homeostasis following chronic doxorubicin administration.

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ICH topic: the draft ICH S7B step 2: note for guidance on safety pharmacology studies for human pharmaceuticals

1 reference

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Cytosolic Ca2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome

1 reference

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Allergic responses reduce the relaxant effect of beta-agonists but not potassium channel openers in guinea-pig isolated trachea

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The proarrhythmic antihistaminic drug terfenadine increases spontaneous calcium release in human atrial myocytes

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7 January 2021

Inositol 1,4,5-trisphosphate receptor is located to the inner nuclear membrane vindicating regulation of nuclear calcium signaling by inositol 1,4,5-trisphosphate. Discrete distribution of inositol phosphate receptors to inner and outer nuclear memb

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7 January 2021

Thyroid disease and the heart

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Cardiotoxicity of antitumor drugs

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Effects of sparfloxacin, grepafloxacin, moxifloxacin, and ciprofloxacin on cardiac action potential duration

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Watersheds in digital spaces: an efficient algorithm based on immersion simulations

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Identifiers

10.1016/J.VASCN.2012.08.167

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

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