(Q36891815)

16 August 2017

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title

Signaling axis in osteoclast biology and therapeutic targeting in the RANKL/RANK/OPG system (English)

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16 August 2017

Sakae Tanaka

1

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PubMed ID

17652963

16 August 2017

language of work or name

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25 July 2007

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American Journal of Nephrology

16 August 2017

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16 August 2017

27

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16 August 2017

5

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16 August 2017

466-478

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Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling

16 August 2017

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Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse

21 January 2018

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Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor

21 January 2018

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Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice

21 January 2018

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Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption

21 January 2018

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

21 January 2018

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Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis

21 January 2018

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Signal transduction pathways regulating osteoclast differentiation and function

21 January 2018

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Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling

21 January 2018

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The molecular understanding of osteoclast differentiation

21 January 2018

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NFAT and Osterix cooperatively regulate bone formation

21 January 2018

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ADAMs: key components in EGFR signalling and development

21 January 2018

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Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival

21 January 2018

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Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase

21 January 2018

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Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding

21 January 2018

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New Insights Into the Molecular Mechanisms of Action of Bisphosphonates

21 January 2018

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 January 2018

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Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts

21 January 2018

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Rho GTPases: biochemistry and biology

21 January 2018

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Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin

21 January 2018

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Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1.

21 January 2018

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Vav3 regulates osteoclast function and bone mass

21 January 2018

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The biochemistry of apoptosis

21 January 2018

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Apoptosis in the development and maintenance of the immune system

21 January 2018

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BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

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Caspases (interleukin-1beta-converting enzyme family proteases) are involved in the regulation of the survival of osteoclasts

21 January 2018

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

21 January 2018

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Is the paradigm shifting?

21 January 2018

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Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients

21 January 2018

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Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand

21 January 2018

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Expression profiles of receptor activator of nuclear factor kappaB ligand, receptor activator of nuclear factor kappaB, and osteoprotegerin messenger RNA in aged and ovariectomized rat bones.

21 January 2018

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Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression

21 January 2018

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Role of RANK ligand in mediating increased bone resorption in early postmenopausal women

21 January 2018

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Correlates of osteoprotegerin levels in women and men.

21 January 2018

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Immunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis

21 January 2018

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Circulating estradiol and osteoprotegerin as determinants of bone turnover and bone density in postmenopausal women

21 January 2018

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Serum parathyroid hormone, but not menopausal status, is associated with the expression of osteoprotegerin and RANKL mRNA in human bone samples.

21 January 2018

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Soluble RANKL and risk of nontraumatic fracture

21 January 2018

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Evolving concepts of rheumatoid arthritis

21 January 2018

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Strategies to control disease in rheumatoid arthritis with tumor necrosis factor antagonists-an opportunity to improve outcomes

21 January 2018

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A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis

21 January 2018

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Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis

21 January 2018

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Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK.

21 January 2018

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Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

21 January 2018

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21 January 2018

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Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis

21 January 2018

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RANK ligand and osteoprotegerin in myeloma bone disease.

21 January 2018

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Characterization of structural domains of human osteoclastogenesis inhibitory factor

21 January 2018

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Adenoviral delivery of osteoprotegerin ameliorates bone resorption in a mouse ovariectomy model of osteoporosis

21 January 2018

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

21 January 2018

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Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection

21 January 2018

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The effect of a single dose of osteoprotegerin in postmenopausal women

21 January 2018

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A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases

21 January 2018

1 reference

A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women

21 January 2018

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Denosumab in postmenopausal women with low bone mineral density

21 January 2018

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The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000106484

1 reference

16 August 2017

1 reference

PubMed ID

17652963