(Q36895457)

16 August 2017

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title

Smoking and lung cancer: future research directions (English)

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16 August 2017

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Hans-Juergen Haussmann

series ordinal

1

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16 August 2017

publication date

1 July 2007

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International Journal of Toxicology

16 August 2017

published in

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16 August 2017

volume

26

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16 August 2017

issue

4

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16 August 2017

page(s)

353-364

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Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With Early Stage Lung Cancer

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Genetic alterations in bronchial mucosa and plasma DNA from individuals at high risk of lung cancer.

21 January 2018

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Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer

21 January 2018

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Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

21 January 2018

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ADAMs: key components in EGFR signalling and development

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Circulating tumour-derived DNA and RNA markers in blood: a tool for early detection, diagnostics, and follow-up?

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Histologic changes in the respiratory tract induced by inhalation of xenobiotics: physiologic adaptation or toxicity?

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Is there a prognostic role of K-ras point mutations in the serum of patients with advanced non-small cell lung cancer?

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Microsatellite alterations in plasma DNA of small cell lung cancer patients.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

A five-gene signature and clinical outcome in non-small-cell lung cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

A minireview of chronic animal inhalation studies with mainstream cigarette smoke

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

K-ras and p16(INK4A)alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Lung inflammation in rats following subchronic exposure to cigarette mainstream smoke.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Biomarkers to assess the utility of potential reduced exposure tobacco products.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10915810701490463

Methods to assess potential reduced exposure products

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Reducing tobacco harm: research challenges and issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Molecular detection approaches for smoking associated tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

ERBB receptors and cancer: the complexity of targeted inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

ADAM8 as a novel serological and histochemical marker for lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Nicotine induces multi-site phosphorylation of Bad in association with suppression of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Mouse models of human non-small-cell lung cancer: raising the bar.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-small-cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Comparative genotoxicity testing of mainstream whole smoke from cigarettes which burn or heat tobacco

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor α-converting Enzyme and Amphiregulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Biomarkers in cancer staging, prognosis and treatment selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Gap junction intercellular communication and cytotoxicity in normal human cells after exposure to smoke condensates from cigarettes that burn or primarily heat tobacco

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Comparative study of smoke condensates from 1R4F cigarettes that burn tobacco versus ECLIPSE cigarettes that primarily heat tobacco in the SENCAR mouse dermal tumor promotion assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Mouse models for human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Clinical value of serum cytokeratin 19 fragment and sialyl-Lewis x in non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

The cellular stress response induced by aqueous extracts of cigarette smoke is critically dependent on the intracellular glutathione concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Evidence for peroxynitrite as an oxidative stress-inducing compound of aqueous cigarette smoke fractions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Use of cigarette-smoking history to estimate the likelihood of mutations in epidermal growth factor receptor gene exons 19 and 21 in lung adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Evaluation of subclinical respiratory tract inflammation in heavy smokers who switch to a cigarette-like nicotine delivery device that primarily heats tobacco.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Short-term exposure evaluation of adult smokers switching from conventional to first-generation electrically heated cigarettes during controlled smoking

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Evaluation of the potential effects of ingredients added to cigarettes. Part 2: chemical composition of mainstream smoke

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Methylation assay for the diagnosis of lung cancer on bronchial aspirates: a cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

The mouse lymphoma thymidine kinase assay for the assessment and comparison of the mutagenic activity of cigarette mainstream smoke particulate phase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Future of early detection of lung cancer: the role of mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Combined detection of CEA, CK-19 and c-met mRNAs in peripheral blood: a highly sensitive panel for potential molecular diagnosis of non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Application of a methylation gene panel by quantitative PCR for lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

SENCAR mouse skin tumorigenesis model versus other strains and stocks of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Mechanisms involved in A/J mouse lung tumorigenesis induced by inhalation of an environmental tobacco smoke surrogate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Gene expression profiling on lung cancer outcome prediction: present clinical value and future premise.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Toxicological evaluation of an electrically heated cigarette. Part 4: Subchronic inhalation toxicology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Toxicological evaluation of an electrically heated cigarette. Part 3: Genotoxicity and cytotoxicity of mainstream smoke

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Dose effect of smoking on aberrant methylation in non-small cell lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Suppression of PTEN expression by NF-kappa B prevents apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Tobacco harm reduction: promise and perils

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

A/J mouse as a model for lung tumorigenesis caused by tobacco smoke: strengths and weaknesses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

The carcinogenic potential of the gas phase of environmental tobacco smoke

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

The carcinogenicity of environmental tobacco smoke

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Lack of the aryl hydrocarbon receptor leads to impaired activation of AKT/protein kinase B and enhanced sensitivity to apoptosis induced via the intrinsic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Application of serum SELDI proteomic patterns in diagnosis of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Nicotine prevents the apoptosis induced by menadione in human lung cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Mutational and Epigenetic Evidence for Independent Pathways for Lung Adenocarcinomas Arising in Smokers and Never Smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

Diagnostic Utility of Serum and Pleural Fluid Carcinoembryonic Antigen, Neuron-Specific Enolase, and Cytokeratin 19 Fragments in Patients With Effusions From Primary Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10915810701490463

10.1080/10915810701490463

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference