(Q34963574)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12379883%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

review article

1 reference

title

Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12379883%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12379883%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

author name string

Hirotaka Osada

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12379883%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

language of work or name

English

0 references

publication date

1 October 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12379883%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12379883%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

volume

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12379883%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

page(s)

7421-7434

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12379883%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

issue

48

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12379883%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205802

13 December 2019

exact match

0 references

cites work

Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours.

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High telomerase activity in primary lung cancers: association with increased cell proliferation rates and advanced pathologic stage.

21 January 2018

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Mice without telomerase: what can they teach us about human cancer?

21 January 2018

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p14ARF links the tumour suppressors RB and p53.

21 January 2018

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Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

21 January 2018

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Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression

21 January 2018

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Mutations of mitotic checkpoint genes in human cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Abnormalities of protooncogenes in non-small cell lung cancer. Correlations with tumor type and clinical characteristics.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

21 January 2018

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Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells

21 January 2018

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Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

21 January 2018

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Fibronectin, integrins, and growth control

21 January 2018

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Inactivation of 14-3-3sigma influences telomere behavior and ionizing radiation-induced chromosomal instability

21 January 2018

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Mutation analysis of the PTEN/MMAC1 gene in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Diversity of gene expression in adenocarcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features

21 January 2018

1 reference

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Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Persistent increase in chromosome instability in lung cancer: possible indirect involvement of p53 inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Inhibition of anchorage-independent growth and lung metastasis of A549 lung carcinoma cells by IkappaBbeta

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Tie receptors: new modulators of angiogenic and lymphangiogenic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis

21 January 2018

1 reference

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Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers.

21 January 2018

1 reference

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Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer

21 January 2018

1 reference

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Molecular characterization of a large homozygous deletion in the small cell lung cancer cell line U2020: a strategy for cloning the putative tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

TGFbeta signaling in growth control, cancer, and heritable disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Protective function of p27(KIP1) against apoptosis in small cell lung cancer cells in unfavorable microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

TGF-beta signaling by Smad proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Restoration of the cellular senescence program and repression of telomerase by human chromosome 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Frequent and histological type-specific inactivation of 14-3-3sigma in human lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

The ras oncogenes in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Cell signaling by receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Analysis of the transcriptional program induced by Raf in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Replacement of Fhit in cancer cells suppresses tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Anticancer therapy targeting the erbB family of receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

The FHIT gene 3p14.2 is abnormal in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Repression of p15INK4b expression by Myc through association with Miz-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Homozygous deletions at 3p12 in breast and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

p53: a frequent target for genetic abnormalities in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Absence of mutations in the transforming growth factor-beta type II receptor in sporadic lung cancers with microsatellite instability and rare H-ras1 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Infrequent mutations of the transforming growth factor beta-type II receptor gene at chromosome 3p22 in human lung cancers with chromosome 3p deletions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Detection of codon 12 K-ras mutations in non-neoplastic mucosa from bronchial carina in patients with lung adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

21 January 2018

Myc activates telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Alterations of the PPP2R1B gene in human lung and colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Molecular damage in the bronchial epithelium of current and former smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Direct activation of TERT transcription by c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Identification and classification of p53-regulated genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

The tumor spectrum in FHIT-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

The pattern of K-ras mutation in pulmonary adenocarcinoma defines a new pathway of tumour development in the human lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Role of FHIT in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF-R1-Flt1 and VEGF-R2-Flk1/KDR) in non-small cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

p53 genetic abnormalities and myc activation in human lung carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Telomerase activity in small-cell and non-small-cell lung cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

MDM2 mRNA expression is a favorable prognostic factor in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Clonal genetic alterations in the lungs of current and former smokers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

High K-ras mutation rates in goblet-cell-type adenocarcinomas of the lungs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Refined mapping of two regions of loss of heterozygosity on chromosome band 11q23 in lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Evolutionary genetics: fruitfly centre spreads its wings.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Vascular endothelial growth factor expression and neovascularisation in non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Bronchial epithelial changes associated with small cell carcinoma of the lung

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Correlation of total VEGF mRNA and protein expression with histologic type, tumor angiogenesis, patient survival and timing of relapse in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205802

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205802

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12379883%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 December 2019

0 references

1 reference