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SIRT1: recent lessons from mouse models.
scientific article published on 24 November 2010
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Europe PubMed Central
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3672967
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17 January 2020
title
SIRT1: recent lessons from mouse models
(English)
1 reference
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Europe PubMed Central
PMCID
3672967
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102633%20AND%20SRC:MED&resulttype=core&format=json
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17 January 2020
author
Daniel Herranz
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1
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Europe PubMed Central
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3672967
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102633%20AND%20SRC:MED&resulttype=core&format=json
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17 January 2020
Manuel Serrano
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2
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Europe PubMed Central
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3672967
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102633%20AND%20SRC:MED&resulttype=core&format=json
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17 January 2020
author name string
Daniel Herranz
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1
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Europe PubMed Central
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3672967
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17 August 2017
Manuel Serrano
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2
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Europe PubMed Central
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3672967
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17 August 2017
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English
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publication date
24 November 2010
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Europe PubMed Central
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3672967
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17 January 2020
published in
Nature Reviews Cancer
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Europe PubMed Central
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3672967
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102633%20AND%20SRC:MED&resulttype=core&format=json
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17 January 2020
volume
10
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Europe PubMed Central
PMCID
3672967
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102633%20AND%20SRC:MED&resulttype=core&format=json
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17 January 2020
issue
12
1 reference
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Europe PubMed Central
PMCID
3672967
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17 January 2020
page(s)
819-823
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3672967
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retrieved
17 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/nrc2962
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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
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SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
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29 September 2017
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis
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29 September 2017
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus
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29 September 2017
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
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29 September 2017
Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress.
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SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
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29 September 2017
SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice
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29 September 2017
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
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29 September 2017
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
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29 September 2017
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
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29 September 2017
Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation
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29 September 2017
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
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29 September 2017
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
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29 September 2017
Mammalian sirtuins: biological insights and disease relevance
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29 September 2017
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice
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29 September 2017
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
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29 September 2017
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
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29 September 2017
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
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29 September 2017
Resveratrol is not a direct activator of SIRT1 enzyme activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer
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29 September 2017
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.
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PubMed Central
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29 September 2017
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
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29 September 2017
SIRT1, is it a tumor promoter or tumor suppressor?
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29 September 2017
How does SIRT1 affect metabolism, senescence and cancer?
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29 September 2017
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
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PubMed Central
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29 September 2017
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
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29 September 2017
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
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29 September 2017
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
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PubMed Central
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29 September 2017
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Sirt1 protects against high-fat diet-induced metabolic damage
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
SirT1 regulates energy metabolism and response to caloric restriction in mice
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
SIRT1 transgenic mice show phenotypes resembling calorie restriction
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols
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29 September 2017
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Sirtuins in mammals: insights into their biological function
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Sirtuins as potential targets for metabolic syndrome
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PubMed Central
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29 September 2017
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Resveratrol improves health and survival of mice on a high-calorie diet
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
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PubMed Central
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29 September 2017
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Sir2 blocks extreme life-span extension.
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PubMed Central
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29 September 2017
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Substrate-specific activation of sirtuins by resveratrol
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
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29 September 2017
Sir2-independent life span extension by calorie restriction in yeast
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29 September 2017
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
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29 September 2017
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
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29 September 2017
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
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29 September 2017
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
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PubMed Central
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29 September 2017
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
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29 September 2017
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
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29 September 2017
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
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29 September 2017
Negative control of p53 by Sir2alpha promotes cell survival under stress
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29 September 2017
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
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29 September 2017
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
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29 September 2017
Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals
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29 September 2017
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
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29 September 2017
Tissue-specific regulation of SIRT1 by calorie restriction
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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29 September 2017
SIRT6 protects against pathological damage caused by diet-induced obesity
1 reference
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PubMed Central
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27 June 2018
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
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27 June 2018
Sirt1 regulates aging and resistance to oxidative stress in the heart
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4 September 2018
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3672967
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4 September 2018
A mid-life crisis for aging theory
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https://api.crossref.org/works/10.1038%2FNRC2962
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31 March 2020
SirT1 fails to affect p53-mediated biological functions
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Crossref
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https://api.crossref.org/works/10.1038%2FNRC2962
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31 March 2020
Increase in activity during calorie restriction requires Sirt1
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRC2962
retrieved
31 March 2020
Identifiers
DOI
10.1038/NRC2962
1 reference
stated in
Europe PubMed Central
PMCID
3672967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102633%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
PMCID
3672967
1 reference
stated in
Europe PubMed Central
PMCID
3672967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102633%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
PubMed ID
21102633
1 reference
stated in
Europe PubMed Central
PMCID
3672967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102633%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
ResearchGate publication ID
49631169
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