(Q36911164)

17 August 2017

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title

The role of nuclear architecture in genomic instability and ageing (English)

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17 August 2017

2

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17 August 2017

Philipp Oberdoerffer

1

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17 August 2017

1 September 2007

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Nature Reviews Molecular Cell Biology

17 August 2017

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17 August 2017

8

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17 August 2017

692-702

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17 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrm2238

17 August 2017

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cites work

Maintenance of stable heterochromatin domains by dynamic HP1 binding

1 reference

Heterochromatin revisited

31 March 2020

1 reference

Chromosomal aberrations: formation, identification and distribution

31 March 2020

1 reference

The heterochromatin loss model of aging

31 March 2020

1 reference

Heterochromatin islands and their dynamic reorganization: a hypothesis for three distinctive features of cellular aging

31 March 2020

1 reference

Replicative senescence: the human fibroblast comes of age.

31 March 2020

1 reference

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

31 March 2020

1 reference

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

31 March 2020

1 reference

Extrachromosomal rDNA circles--a cause of aging in yeast

31 March 2020

1 reference

Replication and transcription: shaping the landscape of the genome

31 March 2020

1 reference

Hutchinson-Gilford progeria syndrome: review of the phenotype.

31 March 2020

1 reference

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

31 March 2020

1 reference

Lamin A-dependent nuclear defects in human aging

31 March 2020

1 reference

Molecular mechanisms of yeast aging

31 March 2020

1 reference

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

31 March 2020

1 reference

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

31 March 2020

1 reference

Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity

31 March 2020

1 reference

Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex

31 March 2020

1 reference

The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation

31 March 2020

1 reference

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

31 March 2020

1 reference

Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

31 March 2020

1 reference

Positional cloning of the Werner's syndrome gene

31 March 2020

1 reference

Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants

31 March 2020

1 reference

DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p.

31 March 2020

1 reference

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

31 March 2020

1 reference

Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths.

31 March 2020

1 reference

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

31 March 2020

1 reference

Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair.

31 March 2020

1 reference

An Age-Induced Switch to a Hyper-Recombinational State

31 March 2020

1 reference

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

31 March 2020

1 reference

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

31 March 2020

1 reference

31 March 2020

1 reference

Influence of ATM function on telomere metabolism

31 March 2020

1 reference

The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

31 March 2020

1 reference

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

31 March 2020

1 reference

Epigenetic memory loss in aging oligodendrocytes in the corpus callosum

31 March 2020

1 reference

Dissociation of Oct-1 from the nuclear peripheral structure induces the cellular aging-associated collagenase gene expression

31 March 2020

1 reference

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA

31 March 2020

1 reference

PML nuclear bodies: dynamic sensors of DNA damage and cellular stress

31 March 2020

1 reference

Cellular senescence in aging primates.

31 March 2020

1 reference

Gene regulation and DNA damage in the ageing human brain

31 March 2020

1 reference

Gene-expression profile of the ageing brain in mice

31 March 2020

1 reference

Gene expression profile of aging and its retardation by caloric restriction

31 March 2020

1 reference

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

31 March 2020

1 reference

Aging and gene expression in the primate brain

31 March 2020

1 reference

Gene expression profiling studies of aging in cardiac and skeletal muscles

31 March 2020

1 reference

Increased cell-to-cell variation in gene expression in ageing mouse heart

31 March 2020

1 reference

Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster

31 March 2020

1 reference

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

31 March 2020

1 reference

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

31 March 2020

1 reference

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

31 March 2020

1 reference

Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation

31 March 2020

1 reference

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

31 March 2020

1 reference

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

31 March 2020

1 reference

Adaptive mechanisms to oxidative stress during aging

31 March 2020

1 reference

Genomic instability in laminopathy-based premature aging

31 March 2020

1 reference

Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis

31 March 2020

1 reference

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

31 March 2020

1 reference

The histone code at DNA breaks: a guide to repair?

31 March 2020

1 reference

Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites

31 March 2020

1 reference

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

31 March 2020

1 reference

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

31 March 2020

1 reference

Megabase chromatin domains involved in DNA double-strand breaks in vivo

31 March 2020

1 reference

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage

31 March 2020

1 reference

The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.

31 March 2020

1 reference

Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.

31 March 2020

1 reference

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

31 March 2020

1 reference

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

31 March 2020

1 reference

Oxidative changes in the DNA of stroma and epithelium from the female breast: potential implications for breast cancer.

31 March 2020

1 reference

DNA structures at chromosomal translocation sites

31 March 2020

1 reference

Gene expression profile of aging in human muscle

31 March 2020

1 reference

Aging: a theory based on free radical and radiation chemistry

31 March 2020

1 reference

Whole-genome views of chromatin structure

31 March 2020

1 reference

Chromatin modifications and their function

31 March 2020

1 reference

Heterochromatin--many flavours, common themes

31 March 2020

1 reference

Perturbation of nuclear architecture by long-distance chromosome interactions.

31 March 2020

1 reference

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

31 March 2020

1 reference

The role of oxidative damage and stress in aging.

31 March 2020

1 reference

Extension of murine life span by overexpression of catalase targeted to mitochondria

31 March 2020

1 reference

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

31 March 2020

1 reference

DNA repair, genome stability, and aging

31 March 2020

1 reference

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

31 March 2020

1 reference

Transcriptional profile of aging in C. elegans.

31 March 2020

1 reference

Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM2238

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17 August 2017

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PubMed ID

17700626