(Q36924592)

English

FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric-coated capsules in cynomolgus macaques

scientific article published on 25 April 2016

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Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric-coated capsules in cynomolgus macaques (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Salman Muzammil

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

John R Mabus

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Philip R Cooper

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Randall J Brezski

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Courtney B Bement

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Rob Perkinson

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Norman D Huebert

7

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Suzanne Thompson

8

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Dalia Levine

9

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Connie Kliwinski

10

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Dino Bradley

11

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Pamela J Hornby

12

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

publication date

25 April 2016

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Pharmacology Research & Perspectives

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

e00218

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

There's been a Flaw in Our Thinking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

The contribution of cell surface FcRn in monoclonal antibody serum uptake from the intestine in suckling rat pups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Polymorphisms of neonatal Fc receptor in cynomolgus and rhesus macaques.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Human and non-human primate intestinal FcRn expression and immunoglobulin G transcytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

AVX-470: a novel oral anti-TNF antibody with therapeutic potential in inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Abundant intracellular IgG in enterocytes and endoderm lacking FcRn

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Neonatal Fc receptor and IgG-based therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Enhanced antibody half-life improves in vivo activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

FcRn-mediated antibody transport across epithelial cells revealed by electron tomography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

The physiology of the lymphatic system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Measurement of gastrointestinal pH profiles in normal ambulant human subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

29 September 2017

Chimeric antibodies with extended half-life in ferrets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

27 June 2018

Novel orally swallowable IntelliCap(®) device to quantify regional drug absorption in human GI tract using diltiazem as model drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

27 June 2018

Ontogenetic development and distribution of antibody transport and Fc receptor mRNA expression in rat intestine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

27 June 2018

Mechanism of precipitation of proteins by polyethylene glycols. Analysis in terms of excluded volume

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

27 June 2018

Fab-related fragments of human IgG produced by partial tryptic proteolysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

27 June 2018

Commentary: "There's been a Flaw in Our Thinking".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

4 September 2018

Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

4 September 2018

Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

4 September 2018

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

4 September 2018

Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

4 September 2018

Oral and pulmonary delivery of FSH-Fc fusion proteins via neonatal Fc receptor-mediated transcytosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

4 September 2018

Specific gravity of whole blood in cynomolgus monkeys (Macaca fascicularis), squirrel monkeys (Saimiri sciureus), and tamarins (Saguinus labiatus) and total blood volume in cynomolgus monkeys.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

4 September 2018

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

4 September 2018

Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876138

4 September 2018

Intestinal Transport and Processing of Immunoglobulin G in the Neonatal and Adult Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/27433338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27433338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/PRP2.218

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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