(Q28252134)

X-ray Crystal Structures of Monomeric and Dimeric Peptide Inhibitors in Complex with the Human Neonatal Fc Receptor, FcRn

published in

Monoclonal Antibodies

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volume

3

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issue

5

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page(s)

422-30

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cites work

1 reference

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Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn

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Podocytes use FcRn to clear IgG from the glomerular basement membrane

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Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor

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Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria

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Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases

29 September 2017

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Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level

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Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway

29 September 2017

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Engineered human IgG antibodies with longer serum half-lives in primates

29 September 2017

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The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland.

29 September 2017

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Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G.

29 September 2017

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Placental transport of immunoglobulin G.

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Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

29 September 2017

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FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells

29 September 2017

1 reference

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Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies

29 September 2017

1 reference

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Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line

29 September 2017

1 reference

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Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway.

29 September 2017

1 reference

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Analysis of a family of antibodies with different half-lives in mice fails to find a correlation between affinity for FcRn and serum half-life

2 June 2018

1 reference

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Historic aspects of intravenous immunoglobulin therapy

2 June 2018

1 reference

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The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release

2 June 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Field flow fractionation for assessing neonatal Fc receptor and Fcγ receptor binding to monoclonal antibodies in solution.

21 January 2018

1 reference

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Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.

21 January 2018

1 reference

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Transport of IgG across the blood-luminal barrier of the male reproductive tract of the rat and the effect of estradiol administration on reabsorption of fluid and IgG by the epididymal ducts.

21 January 2018

1 reference

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Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

An engineered human IgG1 antibody with longer serum half-life.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Prolonged activity of factor IX as a monomeric Fc fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

The pharmacokinetics of an albumin-binding Fab (AB.Fab) can be modulated as a function of affinity for albumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Oral and pulmonary delivery of FSH-Fc fusion proteins via neonatal Fc receptor-mediated transcytosis.

21 January 2018

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https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies

21 January 2018

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Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys

21 January 2018

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12 December 2020

Neonatal FcR Overexpression Boosts Humoral Immune Response in Transgenic Mice

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12 December 2020

Monoclonal antibodies with identical Fc sequences can bind to FcRn differentially with pharmacokinetic consequences

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12 December 2020

Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade

1 reference

12 December 2020

The neonatal Fc receptor (FcRn) expression in the human skin

1 reference

12 December 2020

Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice

1 reference

12 December 2020

Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and Fc

1 reference

12 December 2020

Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1

1 reference

12 December 2020

Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn

1 reference

12 December 2020

FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis

1 reference

12 December 2020

Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

1 reference

12 December 2020

Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies

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12 December 2020

Identifiers

DOI

10.4161/MABS.3.5.16983

1 reference

2097175

2097175

1 reference

1 reference

1 reference