(Q36928403)

English

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C

scientific article published on September 2005

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16134942%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16134942%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Marc C Nicklaus

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16134942%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

author name string

Ji-Hye Kang

1

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6 January 2020

Megan L Peach

2

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6 January 2020

Yongmei Pu

3

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6 January 2020

Nancy E Lewin

4

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6 January 2020

Peter M Blumberg

6

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6 January 2020

Victor E Marquez

7

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6 January 2020

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1 September 2005

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6 January 2020

Journal of Medicinal Chemistry

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6 January 2020

48

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6 January 2020

18

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6 January 2020

5738-5748

1 reference

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6 January 2020

Diacylglycerol's affair with protein kinase C turns 25.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Divergence and complexities in DAG signaling: looking beyond PKC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Activation mechanisms of protein kinase C: maturation, catalytic activation, and targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

A mechanism for the partial insertion of protein kinase C into membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Direct visualization of the translocation of the gamma-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Experimentally determined hydrophobicity scale for proteins at membrane interfaces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Low affinity binding of phorbol esters to protein kinase C and its recombinant cysteine-rich region in the absence of phospholipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

Regulation of protein kinase C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

29 September 2017

[3H]Phorbol 12,13-dibutyrate binding assay for protein kinase C and related proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

27 June 2018

Molecular interaction model for the C1B domain of protein kinase C-gamma in the complex with its activator phorbol-12-myristate-13-acetate in water solution and lipid bilayer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

4 September 2018

Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

4 September 2018

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

4 September 2018

Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

4 September 2018

A General and Efficient Route to Thionoesters via Thionoacyl Nitrobenzotriazoles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

4 September 2018

Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563800

4 September 2018

Protein kinase C ligands based on tetrahydrofuran templates containing a new set of phorbol ester pharmacophores

1 reference

https://pubmed.ncbi.nlm.nih.gov/16134942

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones

1 reference

https://pubmed.ncbi.nlm.nih.gov/16134942

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16134942

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16134942

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM050352M

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16134942%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16134942%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16134942%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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