(Q35579529)

9 August 2017

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title

Divergence and complexities in DAG signaling: looking beyond PKC (English)

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https://api.crossref.org/works/10.1016/J.TIPS.2003.09.003

30 March 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14607084

30 March 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIPS.2003.09.003

30 March 2024

1

ChengFeng Yang

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14607084

30 March 2024

author name string

Marcelo G. Kazanietz

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14607084

30 March 2024

language of work or name

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1 November 2003

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full work available at URL

9 August 2017

https://api.elsevier.com/content/article/PII:S0165614703002864?httpAccept=text/xml

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https://api.crossref.org/works/10.1016/J.TIPS.2003.09.003

https://api.elsevier.com/content/article/PII:S0165614703002864?httpAccept=text/plain

30 March 2024

1 reference

https://api.crossref.org/works/10.1016/J.TIPS.2003.09.003

Trends in Pharmacological Sciences

30 March 2024

published in

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9 August 2017

volume

24

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9 August 2017

issue

11

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9 August 2017

page(s)

602-608

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Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

9 August 2017

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Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha

30 March 2024

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Antisense therapy in oncology: new hope for an old idea?

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Antisense therapy directed to protein kinase C-alpha (affinitak, LY900003/ISIS 3521): Potential role in breast cancer

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Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

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The broad specificity of dominant inhibitory protein kinase C mutants infers a common step in phosphorylation.

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Phorbol esters and neurotransmitter release: more than just protein kinase C?

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Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

30 March 2024

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Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters

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Protein kinase C alpha activates RAF-1 by direct phosphorylation

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PKCalpha-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells.

30 March 2024

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Insulin-activated protein kinase Cbeta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells.

30 March 2024

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Activation of PKC-epsilon and ERK1/2 participates in shear-induced endothelial MCP-1 expression that is repressed by nitric oxide

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Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

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Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta

30 March 2024

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Phorbol ester-induced expression of airway squamous cell differentiation marker, SPRR1B, is regulated by protein kinase Cdelta /Ras/MEKK1/MKK1-dependent/AP-1 signal transduction pathway

30 March 2024

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Sustained activation of p42/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes

30 March 2024

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Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection

30 March 2024

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Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis

30 March 2024

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PKC epsilon -mediated ERK1/2 activation involved in radiation-induced cell death in NIH3T3 cells

30 March 2024

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NF-kappaB activation by protein kinase C isoforms and B-cell function

30 March 2024

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PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling

30 March 2024

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Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha

30 March 2024

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Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes

30 March 2024

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NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

30 March 2024

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Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta

30 March 2024

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Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

30 March 2024

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Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

30 March 2024

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Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells

30 March 2024

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Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells

30 March 2024

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Regulation of cell apoptosis by protein kinase c delta

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Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector

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Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis

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Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta

30 March 2024

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Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C.

30 March 2024

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30 March 2024

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Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway

30 March 2024

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Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9

30 March 2024

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Protein kinase Cδ controls self-antigen-induced B-cell tolerance

30 March 2024

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Increased protein kinase C delta in mammary tumor cells: relationship to transformtion and metastatic progression.

30 March 2024

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Protein kinase C inhibitors

30 March 2024

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Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy

30 March 2024

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Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene

30 March 2024

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Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor

30 March 2024

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Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters

30 March 2024

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beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain

30 March 2024

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Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor

30 March 2024

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Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain

30 March 2024

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30 March 2024

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30 March 2024

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Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain

30 March 2024

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Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma

30 March 2024

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Expression of alpha 1-chimaerin (rac-1 GAP) alters the cytoskeletal and adhesive properties of fibroblasts

30 March 2024

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Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

30 March 2024

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30 March 2024

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30 March 2024

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Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform

30 March 2024

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Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs

30 March 2024

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Protein kinase D: an intracellular traffic regulator on the move

30 March 2024

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Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.

30 March 2024

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Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways

30 March 2024

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Protein kinase D is a downstream target of protein kinase Ctheta

30 March 2024

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Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation.

30 March 2024

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Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

30 March 2024

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Proteolytic cleavage and activation of protein kinase C [micro] by caspase-3 in the apoptotic response of cells to 1-beta -D-arabinofuranosylcytosine and other genotoxic agents

30 March 2024

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Diacylglycerol kinases: emerging downstream regulators in cell signaling systems.

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Properties and functions of diacylglycerol kinases

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Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters.

30 March 2024

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Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes. DGKgamma and DGKbeta are new targets of tumor-promoting phorbol esters

30 March 2024

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Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3

30 March 2024

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Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein

30 March 2024

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Identifiers

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9 August 2017

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