(Q36929602)

17 August 2017

1 reference

title

Inhibition of cytochromes p450: existing and new promising therapeutic targets (English)

1 reference

17 August 2017

2

Rita Bernhardt

1 reference

17 August 2017

Inge Schuster

1

1 reference

PubMed ID

17786634

17 August 2017

language of work or name

English

0 references

publication date

1 January 2007

1 reference

17 August 2017

Drug Metabolism Reviews

1 reference

17 August 2017

39

1 reference

17 August 2017

2-3

1 reference

17 August 2017

481-499

1 reference

Ligand probes for heme proteins.

17 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

17 beta-(cyclopropylamino)-androst-5-en-3 beta-ol, a selective mechanism-based inhibitor of cytochrome P450(17 alpha) (steroid 17 alpha-hydroxylase/C17-20 lyase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Improving the outcome of patients with castration-resistant prostate cancer through rational drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Inhibition of testicular 17 alpha-hydroxylase and 17,20-lyase but not 3 beta-hydroxysteroid dehydrogenase-isomerase or 17 beta-hydroxysteroid oxidoreductase by ketoconazole and other imidazole drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Inhibition of 17 alpha-hydroxylase/C17-C20 lyase by bifluranol and its analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Conferring aldosterone synthesis to human CYP11B1 by replacing key amino acid residues with CYP11B2-specific ones

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

The association of benign prostatic hyperplasia and cancer of the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Aldosterone and myocardial fibrosis in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Aromatase inhibitors in the treatment of breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypert

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Adrenal proteins bound by a reactive intermediate of mitotane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Inhibitors of cytochrome P450 4A suppress angiogenic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

P450-dependent enzymes as targets for prostate cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 chinese hamster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Therapeutic potential of thromboxane inhibitors in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Hospital use of systemic antifungal drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Structural basis for ligand promiscuity in cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Function of human cytochrome P450s: characterization of the orphans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Inhibition of CYP 17, a new strategy for the treatment of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Where do selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) now fit into breast cancer treatment algorithms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Aromatase inhibitors: a safety comparison

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Tumour-specific expression of CYP2W1: its potential as a drug target in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Mechanism-based inactivators as probes of cytochrome P450 structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Induction of cardiac fibrosis by aldosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

P450 in the angiogenesis affair: the unusual suspect

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Cytochrome P450 1B1: a novel anticancer therapeutic target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Noncalcemic Actions of Vitamin D Receptor Ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Cytochrome p450 retinoic acid 4-hydroxylase inhibitors: potential agents for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

How many drug targets are there?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Current concepts for a drug-induced inhibition of formation and action of thromboxane A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

The EPHESUS trial: eplerenone in patients with heart failure due to systolic dysfunction complicating acute myocardial infarction. Eplerenone Post-AMI Heart Failure Efficacy and Survival Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Do diuretics and aldosterone receptor antagonists improve ventricular remodeling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Myocardial fibrosis associated with aldosterone or angiotensin II administration: attenuation by calcium channel blockade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Cytochrome P450 pharmacogenetics and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

The druggable genome: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Kinetic, hormonal and clinical studies with aminoglutethimide in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

The interaction of representative members from two classes of antimycotics--the azoles and the allylamines--with cytochromes P-450 in steroidogenic tissues and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Selective inhibition of vitamin D hydroxylases in human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Estrogen--the good, the bad, and the unexpected.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Aromatase and its inhibitors: significance for breast cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Simultaneous antiandrogen withdrawal and treatment with ketoconazole and hydrocortisone in patients with advanced prostate carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Spironolactone in congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Medical therapy for Cushing's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Inhibitors of P450-dependent steroid biosynthesis: from research to medical treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Aldosterone and the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

Vitamin D in preventive medicine: are we ignoring the evidence?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701498455

10.1080/03602530701498455

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

17786634