(Q36936203)

17 August 2017

Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays (English)

1 reference

17 August 2017

1 reference

ToxCast

25 May 2024

Parth Kothiya

3

0 references

Richard S. Judson

object named as

Richard S Judson

5

0 references

David M. Reif

object named as

David M Reif

4

0 references

David J. Dix

8

object named as

David J Dix

1 reference

17 August 2017

6

Ann M Richard

1 reference

17 August 2017

Nisha S Sipes

1

1 reference

17 August 2017

Matthew T Martin

2

1 reference

17 August 2017

Keith A Houck

7

1 reference

17 August 2017

Robert J Kavlock

9

1 reference

17 August 2017

Thomas B Knudsen

10

1 reference

17 August 2017

16 May 2013

1 reference

Chemical Research in Toxicology

17 August 2017

1 reference

17 August 2017

26

1 reference

17 August 2017

6

1 reference

17 August 2017

878-895

1 reference

describes a project that uses

17 August 2017

Cytoscape

1 reference

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

inferred from PubMed Central ID database lookup

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29 September 2017

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29 September 2017

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Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data

29 September 2017

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Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay

29 September 2017

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Predictive model of rat reproductive toxicity from ToxCast high throughput screening

29 September 2017

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Chemical genomics profiling of environmental chemical modulation of human nuclear receptors

29 September 2017

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29 September 2017

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Structure-based systems biology for analyzing off-target binding

29 September 2017

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29 September 2017

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Personal care products and endocrine disruption: A critical review of the literature

29 September 2017

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Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

29 September 2017

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The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

29 September 2017

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In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

29 September 2017

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Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

29 September 2017

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Predicting new molecular targets for known drugs

29 September 2017

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Steroidal bivalent ligands for the estrogen receptor: design, synthesis, characterization and binding affinities

29 September 2017

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Suppression of estrogenic activity of 17-beta-estradiol by beta-cyclodextrin

29 September 2017

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Toxicology. Transforming environmental health protection

29 September 2017

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Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 mice

29 September 2017

1 reference

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Integration of biological networks and gene expression data using Cytoscape

29 September 2017

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The pipeline and future of drug development in schizophrenia.

29 September 2017

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Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy.

29 September 2017

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In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor

29 September 2017

1 reference

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Systems cell biology based on high-content screening

29 September 2017

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Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

29 September 2017

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Global mapping of pharmacological space

29 September 2017

1 reference

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Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors

29 September 2017

1 reference

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Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans

29 September 2017

1 reference

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Health risks posed by use of Di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review

29 September 2017

1 reference

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Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Atomic structure of progesterone complexed with its receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

From estrogen to androgen receptor: a new pathway for sex hormones in prostate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Minamata disease: methylmercury poisoning in Japan caused by environmental pollution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Neurotoxicity of the pesticidal carbamates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

The mechanism of action of steroid antagonists: insights from crystallographic studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Selective enhancement of [3H]opiate agonist binding by divalent cations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO-K1 cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Biochemical and pharmacological activities of SR 144190, a new potent non-peptide tachykinin NK2 receptor antagonist

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

The in vitro and in vivo pharmacologic activity of the potent and selective leukotriene B4 receptor antagonist CP-105696.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]R05-4864 and [3H]PK 11195, by thermodynamic studies

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Dopamine receptor blockade--a central action of chlorpromazine on striatal neurones.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Dopamine D2/3 receptor binding potential and occupancy in midbrain and temporal cortex by haloperidol, olanzapine and clozapine.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Comparison of chemical binding to recombinant fathead minnow and human estrogen receptors alpha in whole cell and cell-free binding assays.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Quantitative structure-activity relationship of phenoxyphenyl-methanamine compounds with 5HT2A, SERT, and hERG activities

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: structure-activity relationships of (thioalkyl)phenoxy benzylamines

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4-(4-fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profile of CP-544

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Characterization of compound mechanisms and secondary activities by BioMAP analysis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4]triazine: synthesis of an alpha 2/3-selective GABA agonist

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

An investigation of the mode of action of benadryl as an antihistaminic.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Synthesis and SAR of 3- and 4-substituted quinolin-2-ones: discovery of mixed 5-HT(1B)/5-HT(2A) receptor antagonists

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Structural requirements of para-alkylphenols to bind to estrogen receptor.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Binding of antipsychotic drugs to cortical 5-HT2A receptors: a PET study of chlorpromazine, clozapine, and amisulpride in schizophrenic patients

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

The neuropsychiatric sequelae of mercury poisoning. The Mad Hatter's disease revisited.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685188

Discovery of imidazole carboxamides as potent and selective CCK1R agonists

4 December 2018

1 reference

12 December 2020

Asymmetric Synthesis of an Antagonist of Neurokinin Receptors: SSR 241586

1 reference

12 December 2020

QSAR and Metabolic Assessment Tools in the Assessment of Genotoxicity

1 reference

12 December 2020

Advanced trauma life support

1 reference

12 December 2020

A phase I and pharmacologic study of the matrix metalloproteinase inhibitor CP-471,358 in patients with advanced solid tumors

1 reference

12 December 2020

Characterization of the interaction of zamifenacin at muscarinic receptors in vitro

1 reference

12 December 2020

Application of the dried spot sampling technique for rat cerebrospinal fluid sample collection and analysis

1 reference

12 December 2020

Inhibitory action of dithiocarbamates on enzymes of animal tissues

1 reference

12 December 2020

R: A Language for Data Analysis and Graphics

1 reference

COCI

https://opencitations.net/index/api/v1/references/10.1021/TX400021F

Predictive modeling and computational toxicology

25 May 2024

1 reference

COCI

https://opencitations.net/index/api/v1/references/10.1021/TX400021F

25 May 2024

Identifiers

DOI

10.1021/TX400021F

1 reference

release_wkb4aydgsjatzlswpbb6dhmgsy

17 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/wkb4aydgsjatzlswpbb6dhmgsy

24 November 2022

mapped directly with Wikidata item

1 reference

17 August 2017

PubMed publication ID

23611293

1 reference