(Q36939218)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

review article

1 reference

title

Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and delivery (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

author name string

Abeer M Al-Ghananeem

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Peter A Crooks

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

language of work or name

English

0 references

publication date

8 March 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

page(s)

373-388

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

7 January 2020

copyright license

start time

8 March 2007

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

Transscleral drug delivery for posterior segment disease

1 reference

Drug delivery to the retina: challenges and opportunities

21 January 2018

1 reference

Role of metabolism in ocular drug delivery

21 January 2018

1 reference

Ophthalmic drug design based on the metabolic activity of the eye: soft drugs and chemical delivery systems.

21 January 2018

1 reference

Drug disposition in the mammalian eye and brain: a comparison of mechanisms

21 January 2018

1 reference

Ocular toxicity associated with systemic drug therapy

21 January 2018

1 reference

Ophthalmic drug delivery systems--recent advances

21 January 2018

1 reference

Genetic differences in drug metabolism associated with ocular toxicity

21 January 2018

1 reference

Induction of alkoxyresorufin O-dealkylases and UDP-glucuronosyl transferase by phenobarbital and 3-methylcholanthrene in primary cultures of porcine ciliary epithelial cells

21 January 2018

1 reference

The lysosomal enzymes of the iris-ciliary body are retained in their organelles and exhibit increased activities during acute uveal inflammation

21 January 2018

1 reference

Zeta-crystallin from guinea pig lens is capable of functioning catalytically as an oxidoreductase

21 January 2018

1 reference

Detection of aldehyde dehydrogenase activity in human corneal extracts

21 January 2018

1 reference

High levels of aldehyde dehydrogenase transcripts in the undifferentiated chick retina

21 January 2018

1 reference

Glutathione S-transferases of the bovine retina. Evidence that glutathione peroxidase activity is the result of glutathione S-transferase

21 January 2018

1 reference

Differential expression of alpha, µ and pi classes of isozymes of glutathione S-transferase in bovine lens, cornea, and retina

21 January 2018

1 reference

[(Aminomethyl)arloxy]acetic acid esters. A new class of high-ceiling diuretics. 3. Variation in the bridge between the aromatic rings to complete mapping of the receptor.

21 January 2018

1 reference

Lacrimal and Instilled Fluid Dynamics in Rabbit Eyes

21 January 2018

1 reference

Adverse reactions from timolol administration

21 January 2018

1 reference

The hydrolysis of the prostaglandin analog prodrug bimatoprost to 17-phenyl-trinor PGF2alpha by human and rabbit ocular tissue

21 January 2018

1 reference

Evaluation of O(3alpha)-, O(21)-di-(N(1)-methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl) 17alpha-hydroxy-5beta-pregnan-20-one as a novel potential antiangiogenic codrug

21 January 2018

1 reference

Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents

21 January 2018

1 reference

An intravitreal biodegradable sustained release naproxen and 5-fluorouracil system for the treatment of experimental post-traumatic proliferative vitreoretinopathy.

21 January 2018

1 reference

Novel antiglaucoma prodrugs and codrugs of ethacrynic acid

21 January 2018

1 reference

Simultaneous modulation of transport and metabolism of acyclovir prodrugs across rabbit cornea: An approach involving enzyme inhibitors.

21 January 2018

1 reference

Mechanism of corneal permeation of L-valyl ester of acyclovir: targeting the oligopeptide transporter on the rabbit cornea

21 January 2018

1 reference

Carrier mediated uptake of L-tyrosine and its competitive inhibition by model tyrosine linked compounds in a rabbit corneal cell line (SIRC)--strategy for the design of transporter/receptor targeted prodrugs

21 January 2018

1 reference

Modulation of P-glycoprotein-mediated efflux by prodrug derivatization: an approach involving peptide transporter-mediated influx across rabbit cornea.

21 January 2018

1 reference

Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations

21 January 2018

1 reference

A novel water-soluble cyclosporine A prodrug: ocular tolerance and in vivo kinetics

21 January 2018

1 reference

Prodrug approaches to enhancement of physicochemical properties of drugs IV: novel epinephrine prodrug

21 January 2018

1 reference

12 December 2020

Evidence for the presence of N-acetyl transferase in rat retina

1 reference

12 December 2020

Cytochrome P-450 and related components of the microsomal electron transport system in the bovine ciliary body.

1 reference

12 December 2020

Cytochrome P450 dependent metabolism of arachidonic acid in bovine corneal epithelium

1 reference

12 December 2020

Ocular NAD-dependent alcohol dehydrogenase and aldehyde dehydrogenase in the baboon

1 reference

12 December 2020

A novel chemical delivery system comprising an ocular sustained release formulation of a 3alpha, 17alpha, 21-trihydroxy-5beta-pregnan-20-one-BIS-5-fluorouracil [correction of flourouracil] codrug

1 reference

12 December 2020

Ocular diamine oxidase activity

1 reference

12 December 2020

Pilocarpine prodrugs. II. Synthesis, stability, bioconversion, and physicochemical properties of sequentially labile pilocarpine acid diesters

1 reference

12 December 2020

Pilocarpic acid esters as novel sequentially labile pilocarpine prodrugs for improved ocular delivery.

1 reference

12 December 2020

Mercapturic acid pathway enzymes in bovine ocular lens, cornea, retina and retinal pigmented epithelium

1 reference

12 December 2020

Preliminary Pharmacokinetic Model of Pilocarpine Uptake and Distribution in the Eye

1 reference

12 December 2020

Cytochrome P450-mediated prostaglandin omega/omega-1 hydroxylase activities in porcine ciliary body epithelial cells

1 reference

12 December 2020

Monamine oxidase activity in bovine retina: subcellular distribution and drug sensitivities

1 reference

12 December 2020

Immunochemical studies on the contribution of NADPH cytochrome P-450 reductase to the cytochrome P-450-dependent metabolism of arachidonic acid

1 reference

12 December 2020

Polyamines in normal and cataractous human lenses: evidence for post-translational modification

1 reference

12 December 2020

Modified beta-cyclodextrin (SBE7-beta-CyD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrug in rabbits

1 reference

12 December 2020

Miotic effect and irritation potential of pilocarpine prodrug incorporated into a submicron emulsion vehicle

1 reference

12 December 2020

Acetyl- and butyrylcholinesterase activities in the rat retina and retinal pigment epithelium

1 reference

12 December 2020

Adverse respiratory and cardiovascular events attributed to timolol ophthalmic solution, 1978-1985.

1 reference

12 December 2020

Esterase activities in adult rabbit eyes

1 reference

12 December 2020

Cytochrome P450, drug metabolizing enzymes and arachidonic acid metabolism in bovine ocular tissues

1 reference

12 December 2020

Pharmacokinetic evidence for improved ophthalmic drug delivery by reduction of instilled volume

1 reference

12 December 2020

Pilocarpine prodrugs I. Synthesis, physicochemical properties and kinetics of lactonization of pilocarpic acid esters

1 reference

12 December 2020

Ocular side effects of selected systemic drugs

1 reference

12 December 2020

Comparative study of phase II biotransformation in rabbit ocular tissues

1 reference

12 December 2020

New water-soluble pilocarpine derivatives with enhanced and sustained muscarinic activity

1 reference

12 December 2020

MONOAMINE OXIDASE DISTRIBUTION IN THE RABBIT EYE

1 reference

12 December 2020

Hydrolases of anterior segment tissues in the normal human, pig and rat eye: a comparative study

1 reference

12 December 2020

Aryl hydrocarbon hydroxylase induction in retinal pigmented epithelium: possible association of genetic differences in a drug-metabolizing enzyme system with retinal degeneration

1 reference

12 December 2020

Increased hydrolase activities in the human trabecular meshwork of glaucomatous eyes

1 reference

12 December 2020

Ocular absorption and irritation of pilocarpine prodrug is modified with buffer, polymer, and cyclodextrin in the eyedrop

1 reference

12 December 2020

Quantitative evaluation of topically applied pilocarpine in the precorneal area

1 reference

12 December 2020

Genetically regulated aryl hydrocarbon hydroxylase induction in the eye: Possible significance of the drug-metabolizing enzyme system for the retinal pigmented epithelium-choroid

1 reference

12 December 2020

S-adenosyl-L-methionine-mediated enzymatic methylations in the rat retinal membranes

1 reference

12 December 2020

Identifiers

DOI

10.3390/12030373

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17851396%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PubMed publication ID

17851396

1 reference