(Q36940127)

17 August 2017

1 reference

title

Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads (English)

1 reference

G protein-coupled receptor

17 August 2017

main subject

0 references

7

Larry A Sklar

1 reference

17 August 2017

Eric R Prossnitz

6

1 reference

ORCID Public Data File 2021

Tione Buranda

1

object named as

Tione Buranda

1 reference

17 August 2017

Anna Waller

2

1 reference

17 August 2017

Yang Wu

3

1 reference

17 August 2017

Peter C Simons

4

1 reference

17 August 2017

Sean Biggs

5

1 reference

17 August 2017

publication date

1 January 2007

1 reference

Advances in Protein Chemistry

17 August 2017

published in

1 reference

17 August 2017

volume

74

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17 August 2017

page(s)

95-135

1 reference

Heterotrimeric G-protein alpha-subunit adopts a "preactivated" conformation when associated with betagamma-subunits

17 August 2017

cites work

1 reference

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7 January 2021

A fluorescence resonance energy transfer-based sensor indicates that receptor access to a G protein is unrestricted in a living mammalian cell

1 reference

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7 January 2021

RGD-containing peptides inhibit fibrinogen binding to platelet alpha(IIb)beta3 by inducing an allosteric change in the amino-terminal portion of alpha(IIb)

1 reference

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7 January 2021

Real-time analysis of G protein-coupled receptor reconstitution in a solubilized system.

1 reference

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7 January 2021

Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning

1 reference

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7 January 2021

Cell type- and developmental stage-specific activation of NF-kappaB by fMet-Leu-Phe in myeloid cells.

1 reference

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7 January 2021

Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Gi protein activation in intact cells involves subunit rearrangement rather than dissociation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Detection of epitope-tagged proteins in flow cytometry: fluorescence resonance energy transfer-based assays on beads with femtomole resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Constitutive activation of muscarinic receptors by the G-protein Gq.

1 reference

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7 January 2021

Constitutive activation of chimeric m2/m5 muscarinic receptors and delineation of G-protein coupling selectivity domains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Insights into G protein structure, function, and regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Activation of G-protein Galpha subunits by receptors through Galpha-Gbeta and Galpha-Ggamma interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation

1 reference

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7 January 2021

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

G protein-coupled receptor allosterism and complexing

1 reference

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7 January 2021

G-protein-coupled receptor allosterism: the promise and the problem(s).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The G protein subunit gene families

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The state of lipid rafts: from model membranes to cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Molecular basis for interactions of G protein betagamma subunits with effectors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

A high potency nonformylated peptide agonist for the phagocyte N-formylpeptide chemotactic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The uncoupled state of the human formyl peptide receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

G proteins: transducers of receptor-generated signals

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Competition between solution and cell surface receptors for ligand. Dissociation of hapten bound to surface antibody in the presence of solution antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Affinity of guanine nucleotide binding proteins for their ligands: facts and artefacts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Global analysis of G-protein-coupled receptor signaling in human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The many faces of G protein signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

How activated receptors couple to G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Dynamics of beta2-adrenergic receptor-ligand complexes on living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Dynamics of receptor/G protein coupling in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

G-protein diseases furnish a model for the turn-on switch

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Regulation of formyl peptide receptor agonist affinity by reconstitution with arrestins and heterotrimeric G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Signal transduction by a nondissociable heterotrimeric yeast G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Agonist-induced conformational changes in the beta2 adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Modelling of promiscuous receptor-Gi/Gs-protein coupling and effector response

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Molecular dynamics and interactions for creation of stimulation-induced stabilized rafts from small unstable steady-state rafts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The 2.0 A crystal structure of a heterotrimeric G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

G-protein subunit dissociation is not an integral part of G-protein action

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Differential activity of the G protein beta5 gamma2 subunit at receptors and effectors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Direct optical recording of intrinsic efficacy at a G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Interactions between Ras proteins and their effectors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The G protein beta subunit is a determinant in the coupling of Gs to the beta 1-adrenergic and A2a adenosine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Reconstitution of G protein-coupled receptors with recombinant G protein alpha and beta gamma subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Role of isoprenoid lipids on the heterotrimeric G protein gamma subunit in determining effector activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The carboxyl terminus of the Galpha-subunit is the latch for triggered activation of heterotrimeric G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Membrane organization in G-protein mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Regulators of G-protein signalling as new central nervous system drug targets.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Mechanism of agonist and antagonist binding to alpha 2 adrenergic receptors: evidence for a precoupled receptor-guanine nucleotide protein complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Flow cytometry: A versatile tool for all phases of drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The myristoylated amino terminus of Galpha(i)(1) plays a critical role in the structure and function of Galpha(i)(1) subunits in solution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Protein complexes involved in heptahelical receptor-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Does subunit dissociation necessarily accompany the activation of all heterotrimeric G proteins?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Structural and functional relationships of heterotrimeric G-proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Phototransduction: crystal clear

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Conformational changes associated with receptor-stimulated guanine nucleotide exchange in a heterotrimeric G-protein alpha-subunit: NMR analysis of GTPgammaS-bound states

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Translating G protein subunit diversity into functional specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Is there a 'lock' for all agonist 'keys' in 7TM receptors?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Calculation of diffusion-limited kinetics for the reactions in collision coupling and receptor cross-linking

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Functional rafts in cell membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Lipid rafts and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Fluoresceinated chemotactic peptide and high-affinity antifluorescein antibody as a probe of the temporal characteristics of neutrophil stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Solubilization and display of G protein-coupled receptors on beads for real-time fluorescence and flow cytometric analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Flow cytometric analysis of ligand-receptor interactions and molecular assemblies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Crystal structure of a G-protein beta gamma dimer at 2.1A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

G protein mechanisms: insights from structural analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The green fluorescent protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Guanine nucleotide exchange-independent activation of Gs protein by beta2-adrenoceptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

G protein-coupled receptors: a count of 1001 conformations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The guanine nucleotide-binding switch in three dimensions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Contribution of serine residues to constitutive and agonist-induced signaling via the D2S dopamine receptor: evidence for multiple, agonist-specific active conformations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The structure of Ras protein: a model for a universal molecular switch

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Dynamics of fluorescence dequenching of ostrich-quenched fluorescein biotin: a multifunctional quantitative assay for biotin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Small-volume rapid-mix device for subsecond kinetic analysis in flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The development of quantum dot calibration beads and quantitative multicolor bioassays in flow cytometry and microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

Creating new fluorescent probes for cell biology.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

The collisional limit: an important consideration for membrane-associated enzymes and receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974003-2

7 January 2021

10.1016/S0065-3233(07)74003-2

Identifiers

DOI

1 reference

17 August 2017

1 reference