(Q36946331)

17 August 2017

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title

Oxidative stress and excitotoxicity: a therapeutic issue in multiple sclerosis? (English)

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17 August 2017

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1 reference

Gonsette RE

1

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17 August 2017

publication date

19 September 2007

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Multiple Sclerosis Journal

17 August 2017

published in

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17 August 2017

volume

14

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17 August 2017

issue

1

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17 August 2017

page(s)

22-34

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Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Oxidative stress, glutamate, and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Multiple pathways of peroxynitrite cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Microglial cell activation and proliferation precedes the onset of CNS autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Microglia and multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Extensive peroxynitrite activity during progressive stages of central nervous system inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

In vivo damage of CNS myelin and axons induced by peroxynitrite

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

In vitro reactive nitrating species toxicity in dissociated spinal motor neurons from NFL (−/−) andhNFL (+/+) transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Nitric oxide, oxidants, and protein tyrosine nitration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Mitochondrial damage and histotoxic hypoxia: a pathway of tissue injury in inflammatory brain disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

A mitochondrial component of neurodegeneration in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Differential lipid peroxidation, Mn superoxide, and bcl-2 expression contribute to the maturation-dependent vulnerability of oligodendrocytes to oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Nitric oxide synthase expression and enzymatic activity in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Cytokine secretion and nitric oxide production by mononuclear cells of patients with multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Role of tight junction derangement in the endothelial dysfunction elicited by exogenous and endogenous peroxynitrite and poly(ADP-ribose) synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Effects of peroxynitrite and superoxide radicals on endothelial monolayer permeability: potential role of peroxynitrite in preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Neurotransmitters in cerebrospinal fluid reflect pathological activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

The link between excitotoxic oligodendroglial death and demyelinating diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Glutamate uptake by oligodendrocytes: Implications for excitotoxicity in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Abnormal response to glutamate of T lymphocytes from multiple sclerosis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Inflammatory cell expression of cyclooxygenase-2 in the multiple sclerosis lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Axon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Protein co-expression with axonal injury in multiple sclerosis plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Role of mitochondria in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

NMDA receptor activation mediates hydrogen peroxide-induced pathophysiology in rat hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Pathogenesis of multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Drugs modulating the biological effects of peroxynitrite and related nitrogen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Reactions of Manganese Porphyrins with Peroxynitrite and Carbonate Radical Anion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

The carbonate radical anion-induced covalent aggregation of human copper, zinc superoxide dismutase, and alpha-synuclein: intermediacy of tryptophan- and tyrosine-derived oxidation products

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Towards the physiological function of uric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Ischemic preconditioning increases antioxidants in the brain and peripheral organs after cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Uric acid in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Comparison of uric acid and ascorbic acid in protection against EAE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

N-acetyl-L-cysteine ameliorates the inflammatory disease process in experimental autoimmune encephalomyelitis in Lewis rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Analysis of gene expression in MOG-induced experimental autoimmune encephalomyelitis after treatment with a novel brain-penetrating antioxidant

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Bilirubin is an antioxidant of possible physiological importance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Biliverdin reductase: a major physiologic cytoprotectant

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Bilirubin as a potent antioxidant suppresses experimental autoimmune encephalomyelitis: implications for the role of oxidative stress in the development of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Repression of cytochrome P450 1A1 gene expression by oxidative stress: mechanisms and biological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Axonal protection using flecainide in experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

White matter injury mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Glutamate inhibition in MS: the neuroprotective properties of riluzole

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Axonal protection in multiple sclerosis--a particular need during remyelination?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Mitochondrial Protein Nitration Primes Neurodegeneration in Experimental Autoimmune Encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Activation of Kainate Receptors Sensitizes Oligodendrocytes to Complement Attack

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1352458507080111

21 January 2018

Identifiers

DOI

10.1177/1352458507080111

1 reference

17 August 2017

1 reference