(Q36949369)

English

Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells

scientific article published on 03 September 2008

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scholarly article

1 reference

Europe PubMed Central

17 August 2017

Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells (English)

1 reference

Europe PubMed Central

17 August 2017

reactive oxygen species

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

Dong Xiao

1

1 reference

Europe PubMed Central

17 August 2017

Anna A Powolny

2

1 reference

Europe PubMed Central

17 August 2017

Shivendra V Singh

3

1 reference

Europe PubMed Central

17 August 2017

language of work or name

0 references

publication date

3 September 2008

1 reference

Europe PubMed Central

17 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

17 August 2017

283

1 reference

Europe PubMed Central

17 August 2017

44

1 reference

Europe PubMed Central

17 August 2017

30151-30163

1 reference

Europe PubMed Central

17 August 2017

Paradoxical effect of diphenyleneiodonium in inducing DNA damage and apoptosis

1 reference

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Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress

1 reference

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29 September 2017

Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis

1 reference

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29 September 2017

Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

1 reference

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29 September 2017

The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells

1 reference

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29 September 2017

Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound

1 reference

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29 September 2017

Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak.

1 reference

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29 September 2017

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

1 reference

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29 September 2017

D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1.

1 reference

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29 September 2017

Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential

1 reference

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29 September 2017

JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells

1 reference

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29 September 2017

c-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells

1 reference

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29 September 2017

Cancer statistics, 2006

1 reference

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Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis

1 reference

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29 September 2017

Critical role of reactive oxygen species and mitochondrial membrane potential in Korean mistletoe lectin-induced apoptosis in human hepatocarcinoma cells

1 reference

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Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways

1 reference

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Meta-analysis of vascular and neoplastic events associated with tamoxifen

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29 September 2017

Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells

1 reference

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29 September 2017

Selected isothiocyanates rapidly induce growth inhibition of cancer cells.

1 reference

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29 September 2017

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis

1 reference

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29 September 2017

Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta

1 reference

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29 September 2017

Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2.

1 reference

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29 September 2017

Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans

1 reference

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29 September 2017

Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis

1 reference

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29 September 2017

Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism

1 reference

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29 September 2017

Mitochondria, oxygen free radicals, and apoptosis

1 reference

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29 September 2017

Inhibition of carcinogenesis by isothiocyanates

1 reference

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29 September 2017

Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis

1 reference

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29 September 2017

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

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Mitochondrial DNA depletion causes morphological changes in the mitochondrial reticulum of cultured human cells

1 reference

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29 September 2017

Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates

1 reference

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29 September 2017

Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms

1 reference

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Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Study of Osteoporotic Fractures Research Group

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Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

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Functional F1-ATPase essential in maintaining growth and membrane potential of human mitochondrial DNA-depleted rho degrees cells

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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

1 reference

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Mitochondria-mediated transformation of human rho(0) cells

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Reproductive factors and breast cancer

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Breast cancer: cause and prevention

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Sequence and organization of the human mitochondrial genome

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Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

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29 September 2017

Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds2

1 reference

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29 September 2017

A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation

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Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.

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A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1).

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Isothiocyanates as substrates for human glutathione transferases: structure-activity studies.

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Dietary isothiocyanates modify mitochondrial functions through their electrophilic reaction

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Effects of MEK1 and PI3K inhibitors on allyl-, benzyl- and phenylethyl-isothiocyanate-induced G2/M arrest and cell death in Caco-2 cells.

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Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent

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Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells

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Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography–tandem mass spectrometry

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Requirement of a carbon spacer in benzyl isothiocyanate-mediated cytotoxicity and MAPK activation in head and neck squamous cell carcinoma.

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Urinary isothiocyanate levels, brassica, and human breast cancer.

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1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Fruit and vegetable intakes and prostate cancer risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/18768478

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based on heuristic

inferred from PubMed ID database lookup

Physical activity and breast cancer risk in women aged 20-54 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/18768478

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based on heuristic

inferred from PubMed ID database lookup

Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models

1 reference

https://pubmed.ncbi.nlm.nih.gov/18768478

12 December 2020

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inferred from PubMed ID database lookup

Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18768478

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based on heuristic

inferred from PubMed ID database lookup

Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/18768478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M802529200

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

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