(Q36961166)

17 August 2017

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title

New molecular insights into cellular survival and stress responses: neuroprotective role of cellular prion protein (PrPC). (English)

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17 August 2017

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Raymond Yen-Yu Lo

1

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17 August 2017

Woei-Cherng Shyu

2

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17 August 2017

Shinn-Zong Lin

3

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17 August 2017

Hsiao-Jung Wang

4

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17 August 2017

Shun-Sheng Chen

5

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17 August 2017

Hung Li

6

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17 August 2017

publication date

1 June 2007

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17 August 2017

published in

Molecular Neurobiology

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17 August 2017

volume

35

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17 August 2017

issue

3

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17 August 2017

page(s)

236-244

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https://scigraph.springernature.com/pub.10.1007/s12035-007-8003-y

17 August 2017

exact match

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cites work

Prion protein expression and superoxide dismutase activity

1 reference

https://api.crossref.org/works/10.1007%2FS12035-007-8003-Y

Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-007-8003-Y

Prion protein accumulation and neuroprotection in hypoxic brain damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-007-8003-Y

Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-007-8003-Y

Mice devoid of PrP are resistant to scrapie

21 January 2018

1 reference

12 December 2020

Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro

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12 December 2020

Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity.

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12 December 2020

PrP(106-126) activates neuronal intracellular kinases and Egr1 synthesis through activation of NADPH-oxidase independently of PrPc

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12 December 2020

Abnormal synaptic protein expression and cell death in murine scrapie.

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12 December 2020

The cellular prion protein modulates phagocytosis and inflammatory response

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12 December 2020

Effects of copper on survival of prion protein knockout neurons and glia.

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12 December 2020

Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies

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12 December 2020

Upregulation of cellular prion protein (PrPc) after focal cerebral ischemia and influence of lesion severity

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12 December 2020

Cellular prion protein: on the road for functions

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12 December 2020

Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss

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12 December 2020

Antioxidant activity related to copper binding of native prion protein

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12 December 2020

Role of the prion protein in copper turnover in astrocytes

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12 December 2020

Cellular prion protein: implications in seizures and epilepsy

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12 December 2020

Bax deletion does not protect neurons from BSE-induced death.

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12 December 2020

Lack of prion protein expression results in a neuronal phenotype sensitive to stress

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12 December 2020

Cellular prion protein transduces neuroprotective signals

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12 December 2020

Astrocytes accumulate 4-hydroxynonenal adducts in murine scrapie and human Creutzfeldt-Jakob disease

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12 December 2020

Cellular prion protein neuroprotective function: implications in prion diseases

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12 December 2020

Neuronal migration in cerebellar microcultures is inhibited by antibodies against a neurite outgrowth domain of laminin

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12 December 2020

Prion protein protects human neurons against Bax-mediated apoptosis

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12 December 2020

Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells

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12 December 2020

Copper-dependent functions for the prion protein

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12 December 2020

Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection

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12 December 2020

Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal

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12 December 2020

Aberrant metal binding by prion protein in human prion disease.

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12 December 2020

Increased Sensitivity to Seizures in Mice Lacking Cellular Prion Protein

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12 December 2020

Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain

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12 December 2020

Copper and prion disease

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12 December 2020

Imbalance of antioxidant defense in mice lacking cellular prion protein.

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12 December 2020

Developmental expression of the prion protein gene in glial cells.

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12 December 2020

The biology of the cellular prion protein

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12 December 2020

Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.

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12 December 2020

Tethering the N-terminus of the prion protein compromises the cellular response to oxidative stress

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12 December 2020

Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons

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12 December 2020

Differential expression of Bax and Bcl-2 in the brains of hamsters infected with 263K scrapie agent

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12 December 2020

Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function.

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12 December 2020

Ablation of cellular prion protein expression affects mitochondrial numbers and morphology

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12 December 2020

Normal brain mitochondrial respiration in adult mice lacking cellular prion protein.

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12 December 2020

PrP cooperates with STI1 to regulate SOD activity in PrP-deficient neuronal cell line.

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12 December 2020

Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth.

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12 December 2020

Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells

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12 December 2020

Human Doppel and prion protein share common membrane microdomains and internalization pathways

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12 December 2020

Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy

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12 December 2020

Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival

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12 December 2020

Cortical malformations are associated with a rare polymorphism of cellular prion protein

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12 December 2020

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel

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12 December 2020

Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions

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12 December 2020

Mitochondrial dysfunction in neurodegenerative diseases associated with copper imbalance

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12 December 2020

Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress

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12 December 2020

Peroxide detoxification by brain cells.

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12 December 2020

Hippocampal synaptic plasticity in mice devoid of cellular prion protein

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12 December 2020

Tumor necrosis factor attenuates prion protein-deficient neuronal cell death by increases in anti-apoptotic Bcl-2 family proteins.

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12 December 2020

Neuroprotective functions of prion protein

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12 December 2020

Prion infection impairs the cellular response to oxidative stress

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12 December 2020

Prion protein protects against DNA damage induced by paraquat in cultured cells

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12 December 2020

NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.

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12 December 2020

Intrinsic resistance of oligodendrocytes to prion infection.

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12 December 2020

Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein

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12 December 2020

Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion

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12 December 2020

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12 December 2020

Defining the role of the Bcl-2 family of proteins in the nervous system

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12 December 2020

The Src family tyrosine kinase Fyn regulates natural killer T cell development

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12 December 2020

Prion protein peptide neurotoxicity can be mediated by astrocytes

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12 December 2020

Prion disease: A loss of antioxidant function?

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12 December 2020

Bcl-2 family regulation of neuronal development and neurodegeneration.

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12 December 2020

Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106-126.

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12 December 2020

Normal prion protein has an activity like that of superoxide dismutase.

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12 December 2020

Deletion of cellular prion protein results in reduced Akt activation, enhanced postischemic caspase-3 activation, and exacerbation of ischemic brain injury

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12 December 2020

Involvement of caveolae and caveolae-like domains in signalling, cell survival and angiogenesis

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12 December 2020

Purkinje-cell degeneration in prion protein-deficient mice is associated with a cerebellum-specific Doppel protein species signature.

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12 December 2020

Aggravation of ischemic brain injury by prion protein deficiency: role of ERK-1/-2 and STAT-1.

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12 December 2020

The cellular prion protein (PrPC) prevents apoptotic neuronal cell death and mitochondrial dysfunction induced by serum deprivation

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12 December 2020

Unraveling the mechanisms involved in motor neuron degeneration in ALS

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12 December 2020

Prion and prejudice: normal protein and the synapse

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12 December 2020

Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery

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12 December 2020

Analysis of doppel protein toxicity

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12 December 2020

Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis

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12 December 2020

Cellular prion protein binds laminin and mediates neuritogenesis

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12 December 2020

Physiological and pathological functions of the prion protein homologue Dpl

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12 December 2020

Hyperbaric oxygen enhances the expression of prion protein and heat shock protein 70 in a mouse neuroblastoma cell line

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12 December 2020

Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrPC

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12 December 2020

Differential contribution of superoxide dismutase activity by prion protein in vivo

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12 December 2020

Scrapie prion proteins are synthesized in neurons

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12 December 2020

Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways.

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12 December 2020

Female-specific neuroprotection against transient brain ischemia observed in mice devoid of prion protein is abolished by ectopic expression of prion protein-like protein

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12 December 2020

Signal transduction through prion protein

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12 December 2020

Overexpression of PrPC by adenovirus-mediated gene targeting reduces ischemic injury in a stroke rat model.

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12 December 2020

Cellular prion protein sensitizes neurons to apoptotic stimuli through Mdm2-regulated and p53-dependent caspase 3-like activation

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12 December 2020

Doppel: the prion's double

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12 December 2020

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

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12 December 2020

Molecular modulation of expression of prion protein by heat shock

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12 December 2020

Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death

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12 December 2020

Domain-specific antibodies against the B2 chain of laminin inhibit neuronal migration in the neonatal rat cerebellum

1 reference

12 December 2020

Correlation between Bax overexpression and prion deposition in medulla oblongata from natural scrapie without evidence of apoptosis.

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12 December 2020

Mossy fibre reorganization in the hippocampus of prion protein null mice.

1 reference

12 December 2020

Hypoglycemia enhances the expression of prion protein and heat-shock protein 70 in a mouse neuroblastoma cell line

1 reference

12 December 2020

10.1007/S12035-007-8003-Y

Identifiers

DOI

1 reference

17 August 2017

1 reference