(Q36006619)

11 August 2017

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title

Cellular prion protein neuroprotective function: implications in prion diseases (English)

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11 August 2017

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Xavier Roucou

1

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11 August 2017

Andréa C LeBlanc

series ordinal

2

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11 August 2017

publication date

10 November 2004

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Journal of Molecular Medicine

11 August 2017

published in

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11 August 2017

volume

83

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11 August 2017

issue

1

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11 August 2017

page(s)

3-11

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Prions prevent neuronal cell-line death.

11 August 2017

cites work

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12 December 2020

Mice devoid of PrP are resistant to scrapie

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12 December 2020

Prion Protein-Deficient Cells Show Altered Response to Oxidative Stress Due to Decreased SOD-1 Activity

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12 December 2020

Transfection of prion protein gene suppresses coxsackievirus B3 replication in prion protein gene-deficient cells.

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12 December 2020

Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies

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12 December 2020

Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.

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12 December 2020

Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl.

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12 December 2020

Mutant prion proteins are partially retained in the endoplasmic reticulum

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12 December 2020

Cellular prion protein status in sheep: tissue-specific biochemical signatures

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12 December 2020

Conversion of Bcl-2 to a Bax-like death effector by caspases

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12 December 2020

Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene

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12 December 2020

Regulation of protein topology by trans-acting factors at the endoplasmic reticulum

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12 December 2020

PrPC directly interacts with proteins involved in signaling pathways

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12 December 2020

Impairment of superoxide dismutase activation by N-terminally truncated prion protein (PrP) in PrP-deficient neuronal cell line

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12 December 2020

Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration

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12 December 2020

A human prion protein peptide (PrP59–91) protects against copper neurotoxicity

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12 December 2020

Lack of prion protein expression results in a neuronal phenotype sensitive to stress

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12 December 2020

Cellular prion protein transduces neuroprotective signals

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12 December 2020

Prion protein protects human neurons against Bax-mediated apoptosis

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12 December 2020

Intercellular transfer of the cellular prion protein

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12 December 2020

Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection

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12 December 2020

Increased Sensitivity to Seizures in Mice Lacking Cellular Prion Protein

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12 December 2020

Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain

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12 December 2020

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

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12 December 2020

Prion protein interactions with nucleic acid: possible models for prion disease and prion function

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12 December 2020

Imbalance of antioxidant defense in mice lacking cellular prion protein.

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12 December 2020

No superoxide dismutase activity of cellular prion protein in vivo

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12 December 2020

Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation

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12 December 2020

Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases

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12 December 2020

Breaking the mitochondrial barrier

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12 December 2020

Familial spongiform encephalopathy associated with a novel prion protein gene mutation

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12 December 2020

Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons

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12 December 2020

Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function

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12 December 2020

Modulation of cell death by Bcl-XL through caspase interaction

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12 December 2020

An amber mutation of prion protein in Gerstmann-Sträussler syndrome with mutant PrP plaques

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12 December 2020

A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination

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12 December 2020

Analysis of interaction sites in homo- and heteromeric complexes containing Bcl-2 family members and the cellular prion protein

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12 December 2020

Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein

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12 December 2020

Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival

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12 December 2020

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel

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12 December 2020

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions

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12 December 2020

Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies

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12 December 2020

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

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12 December 2020

Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions

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12 December 2020

Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain

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12 December 2020

Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment

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12 December 2020

A transmembrane form of the prion protein in neurodegenerative disease

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12 December 2020

Neuroprotective functions of prion protein

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12 December 2020

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

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12 December 2020

Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease

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12 December 2020

NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.

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12 December 2020

Conformational control of Bax localization and apoptotic activity by Pro168.

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12 December 2020

Heat shock modulates prion protein expression in human NT-2 cells

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12 December 2020

Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein

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12 December 2020

Normal prion protein has an activity like that of superoxide dismutase.

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12 December 2020

Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity

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12 December 2020

Neuron-specific mRNA complexity responses during hippocampal apoptosis after traumatic brain injury.

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12 December 2020

The cellular prion protein (PrPC) prevents apoptotic neuronal cell death and mitochondrial dysfunction induced by serum deprivation

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12 December 2020

Transmissible and genetic prion diseases share a common pathway of neurodegeneration

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12 December 2020

Prions prevent brain damage after experimental brain injury: a preliminary report

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12 December 2020

Extracellular-signal-regulated kinase signalling in neurons

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12 December 2020

PrP knock-out and PrP transgenic mice in prion research

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12 December 2020

The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system

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12 December 2020

No propagation of prions in mice devoid of PrP.

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12 December 2020

The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein

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12 December 2020

129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

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12 December 2020

Novel proteinaceous infectious particles cause scrapie

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12 December 2020

Cellular prion protein binds laminin and mediates neuritogenesis

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12 December 2020

Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels

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12 December 2020

BAX is required for neuronal death after trophic factor deprivation and during development

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12 December 2020

Proteasomal Degradation and N-terminal Protease Resistance of the Codon 145 Mutant Prion Protein

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12 December 2020

Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

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12 December 2020

Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene

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12 December 2020

Differential contribution of superoxide dismutase activity by prion protein in vivo

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12 December 2020

Scrapie prion proteins are synthesized in neurons

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12 December 2020

Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways

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12 December 2020

Signal transduction through prion protein

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12 December 2020

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

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12 December 2020

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

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12 December 2020

Glycosyl phosphatidylinositol anchor

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12 December 2020

Cellular prion protein sensitizes neurons to apoptotic stimuli through Mdm2-regulated and p53-dependent caspase 3-like activation

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12 December 2020

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

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12 December 2020

Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death

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12 December 2020

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS.

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12 December 2020

Cellular prion protein function in copper homeostasis and redox signalling at the synapse

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12 December 2020

Analysis of the interactions between HIV-1 and the cellular prion protein in a human cell line

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12 December 2020

10.1007/S00109-004-0605-5

Identifiers

DOI

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11 August 2017

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