(Q36961595)

17 August 2017

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title

Target deconvolution strategies in drug discovery (English)

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17 August 2017

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Georg C Terstappen

1

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17 August 2017

Christina Schlüpen

series ordinal

2

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17 August 2017

Roberto Raggiaschi

series ordinal

3

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17 August 2017

Giovanni Gaviraghi

series ordinal

4

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17 August 2017

1 November 2007

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Nature Reviews Drug Discovery

17 August 2017

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17 August 2017

6

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17 August 2017

11

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17 August 2017

891-903

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https://scigraph.springernature.com/pub.10.1038/nrd2410

17 August 2017

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cites work

Finishing the euchromatic sequence of the human genome

1 reference

Initial sequencing and analysis of the human genome

31 March 2020

1 reference

The Sequence of the Human Genome

31 March 2020

1 reference

How many drug targets are there?

31 March 2020

1 reference

Target-based drug discovery: is something wrong?

31 March 2020

1 reference

Can cell systems biology rescue drug discovery?

31 March 2020

1 reference

From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes

31 March 2020

1 reference

High Throughput Scintillation Proximity Assay for the Identification of FKBP-12 Ligands

31 March 2020

1 reference

MASPIT: three-hybrid trap for quantitative proteome fingerprinting of small molecule-protein interactions in mammalian cells

31 March 2020

1 reference

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

31 March 2020

1 reference

A three-hybrid system for detecting small ligand-protein receptor interactions

31 March 2020

1 reference

Drug receptor identification from multiple tissues using cellular-derived mRNA display libraries

31 March 2020

1 reference

Display cloning: functional identification of natural product receptors using cDNA-phage display

31 March 2020

1 reference

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

31 March 2020

1 reference

Microarrays of cells expressing defined cDNAs

31 March 2020

1 reference

Affinity Chromatography and Purification of the Insulin Receptor of Liver Cell Membranes

31 March 2020

1 reference

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

31 March 2020

1 reference

Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography

31 March 2020

1 reference

Luminescent visualization of antigens on blots

31 March 2020

1 reference

Mass spectrometry and the age of the proteome

31 March 2020

1 reference

Directed immobilization of peptide ligands to accessible pore sites by conjugation with a placeholder molecule

31 March 2020

1 reference

3 Hydrophobic chromatography

31 March 2020

1 reference

Design and synthesis of novel hydrophilic spacers for the reduction of nonspecific binding proteins on affinity resins

31 March 2020

1 reference

Roscovitine targets, protein kinases and pyridoxal kinase

31 March 2020

1 reference

Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin

31 March 2020

1 reference

An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

31 March 2020

1 reference

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

31 March 2020

1 reference

Dissection of melanogenesis with small molecules identifies prohibitin as a regulator

31 March 2020

1 reference

Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division

31 March 2020

1 reference

High-performance affinity beads for identifying drug receptors

31 March 2020

1 reference

The affinity technology in downstream processing

31 March 2020

1 reference

Discovery of novel targets of quinoline drugs in the human purine binding proteome

31 March 2020

1 reference

Quantitative chemical proteomics for identifying candidate drug targets

31 March 2020

1 reference

A versatile method of identifying specific binding proteins on affinity resins.

31 March 2020

1 reference

A novel genetic system to detect protein-protein interactions

31 March 2020

1 reference

A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors

31 March 2020

1 reference

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

31 March 2020

1 reference

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

31 March 2020

1 reference

Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

31 March 2020

1 reference

A phage display technique for a fast, sensitive, and systematic investigation of protein-protein interactions

31 March 2020

1 reference

A new curcumin derivative, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2+/calmodulin function

31 March 2020

1 reference

An in vitro polysome display system for identifying ligands from very large peptide libraries

31 March 2020

1 reference

In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries

31 March 2020

1 reference

31 March 2020

Protein chip technology

1 reference

Tor signalling in bugs, brain and brawn

31 March 2020

1 reference

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

31 March 2020

1 reference

Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components

31 March 2020

1 reference

Chemical genetics: tailoring tools for cell biology

31 March 2020

1 reference

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

31 March 2020

1 reference

Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility

31 March 2020

1 reference

A genome-wide overexpression screen in yeast for small-molecule target identification

31 March 2020

1 reference

Ligand selectivity and competition between enzymes in silico

31 March 2020

1 reference

Annotating the human proteome: beyond establishing a parts list

31 March 2020

1 reference

Functional genomics to new drug targets

31 March 2020

1 reference

Rethinking target discovery in polygenic diseases.

31 March 2020

1 reference

Can the pharmaceutical industry reduce attrition rates?

31 March 2020

1 reference

Preparation of a biochip on porous silicon and application for label-free detection of small molecule-protein interactions.

31 March 2020

1 reference

Small-molecule synergist of the Wnt/beta-catenin signaling pathway

31 March 2020

1 reference

Complex phenotypic assays in high-throughput screening

31 March 2020

1 reference

Chemical genetic approaches to probing cell death

31 March 2020

1 reference

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

31 March 2020

1 reference

Mining the Wnt pathway for cancer therapeutics

31 March 2020

1 reference

Cellular imaging in drug discovery

31 March 2020

1 reference

Pharmacogenomics of the polyamine analog 3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride, CGC-11093, in the colon adenocarcinoma cell line HCT1161.

31 March 2020

1 reference

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

31 March 2020

1 reference

A bioinformatics perspective on proteomics: data storage, analysis, and integration

31 March 2020

1 reference

Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD2410

1 reference

17 August 2017

1 reference