(Q36965969)

English

Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.

scientific article published on March 2006

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scholarly article

1 reference

Europe PubMed Central

17 August 2017

Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. (English)

1 reference

Europe PubMed Central

17 August 2017

0 references

Streptomyces atroolivaceus

1 reference

1 reference

(2R,4'R,6R,9Z,11R,13Z,15E)-4',11-dihydroxy-2,4',9-trimethyl-1'-oxospiro[19-thia-3,20-diazabicyclo[15.2.1]icosa-1(20),9,13,15,17-pentaene-6,5'-dithiolane]-3',4,12-trione

1 reference

author name string

Gong-Li Tang

1

1 reference

Europe PubMed Central

17 August 2017

Yi-Qiang Cheng

2

1 reference

Europe PubMed Central

17 August 2017

Ben Shen

3

1 reference

Europe PubMed Central

17 August 2017

publication date

1 March 2006

1 reference

Europe PubMed Central

17 August 2017

full work available at URL

https://europepmc.org/articles/pmc2579989?pdf=render

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1021/np050467t?email=unpaywall_01@example.com

Journal of Natural Products

1 reference

Europe PubMed Central

17 August 2017

69

1 reference

Europe PubMed Central

17 August 2017

3

1 reference

Europe PubMed Central

17 August 2017

387-393

1 reference

Europe PubMed Central

17 August 2017

online access status

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1021/np050467t?email=unpaywall_01@example.com

access restriction status

1 reference

based on heuristic

inferred from online access status

Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

Genetic Contributions to Understanding Polyketide Synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

Polyketide biosynthesis: a millennium review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

Solution structure of B. subtilis acyl carrier protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

A multiplasmid approach to preparing large libraries of polyketides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

29 September 2017

A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

27 June 2018

Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

4 September 2018

Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

4 September 2018

Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

4 September 2018

The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

4 September 2018

The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

4 September 2018

Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579989

4 September 2018

Alternative modular polyketide synthase expression controls macrolactone structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/16562841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16562841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Harnessing the biosynthetic code: combinations, permutations, and mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16562841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16562841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DC 107, a novel antitumor antibiotic produced by a Streptomyces sp

1 reference

https://pubmed.ncbi.nlm.nih.gov/16562841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/NP050467T

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

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0 references

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