(Q60301869)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11358694%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase (English)

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7 November 2019

12

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7 November 2019

author name string

C J Rowe

1

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7 November 2019

I U Böhm

2

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7 November 2019

I P Thomas

3

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7 November 2019

B Wilkinson

4

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7 November 2019

B A Rudd

5

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7 November 2019

G Foster

6

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7 November 2019

A P Blackaby

7

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7 November 2019

P J Sidebottom

8

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7 November 2019

Y Roddis

9

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7 November 2019

A D Buss

10

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7 November 2019

J Staunton

11

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7 November 2019

publication date

1 May 2001

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7 November 2019

published in

Chemistry and Biology

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7 November 2019

volume

8

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7 November 2019

page(s)

475-485

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7 November 2019

issue

5

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An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

7 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Modular organization of genes required for complex polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

A hybrid modular polyketide synthase obtained by domain swapping

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Production of a novel polyketide through the construction of a hybrid polyketide synthase.

1 reference

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7 January 2021

Engineering broader specificity into an antibiotic-producing polyketide synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Dissecting and exploiting intermodular communication in polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Evidence for a double-helical structure for modular polyketide synthases.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

The thioesterase of the erythromycin-producing polyketide synthase: mechanistic studies in vitro to investigate its mode of action and substrate specificity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

The Thioesterase of the Erythromycin-Producing Polyketide Synthase: Influence of Acyl Chain Structure on the Mode of Release of Substrate Analogues from the Acyl Enzyme Intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Construction of new vectors for high-level expression in actinomycetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Isolation of isoflavones from soy-based fermentations of the erythromycin-producing bacterium Saccharopolyspora erythraea

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Alternative modular polyketide synthase expression controls macrolactone structure

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

High efficiency transformation of E. coli by high voltage electroporation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

Transformation of Streptomyces erythraeus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900024-2

7 January 2021

10.1016/S1074-5521(01)00024-2

Identifiers

DOI

1 reference

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7 November 2019

1 reference