(Q36978824)

17 August 2017

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title

Breaking the bonds: non-viral vectors become chemically dynamic (English)

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17 August 2017

Jon A Wolff

1

1 reference

PubMed ID

17955026

17 August 2017

David B Rozema

series ordinal

2

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17 August 2017

23 October 2007

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17 August 2017

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17 August 2017

16

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17 August 2017

1

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17 August 2017

8-15

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The "grand" problem of synthetic delivery

17 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Complexes of non-cationic liposomes and histone H1 mediate efficient transfection of DNA without encapsulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Protein/amphipathic polyamine complexes enable highly efficient transfection with minimal toxicity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

1 reference

7 January 2021

Lipid-based nanoparticles for nucleic acid delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Layer-by-layer deposition of oppositely charged polyelectrolytes on the surface of condensed DNA particles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Recharging cationic DNA complexes with highly charged polyanions for in vitro and in vivo gene delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

pH-sensitive, cationic liposomes: a new synthetic virus-like vector

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Polyethylene glycol-conjugated copolymers for plasmid DNA delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Cyclodextrin-modified polyethylenimine polymers for gene delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Monomolecular DNA nanoparticles for intravenous delivery of genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Dimerizable cationic detergents with a low cmc condense plasmid DNA into nanometric particles and transfect cells in culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Controlled template-assisted assembly of plasmid DNA into nanometric particles with high DNA concentration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Self-assembly of DNA-polymer complexes using template polymerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Caged DNA does not aggregate in high ionic strength solutions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Development of long-circulating polyelectrolyte complexes for systemic delivery of genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Characteristics and biodistribution of cationic liposomes and their DNA complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Hepatocyte targeting of nucleic acid complexes and liposomes by a T7 phage p17 peptide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Exploitation of intracellular pH gradients in the cellular delivery of macromolecules

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Entry of animal viruses and macromolecules into cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

1 reference

7 January 2021

Enhanced plasmid DNA transfection with lysosomotropic agents in cultured fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Polyethylenimine-mediated gene delivery: a mechanistic study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Effects of polyethyleneimine on endocytosis and lysosome stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Towards synthetic viruses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Efficient gene transfer by histidylated polylysine/pDNA complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Current status of pH-sensitive liposomes in drug delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Membrane permeabilization and efficient gene transfer by a peptide containing several histidines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Application of membrane-active peptides for drug and gene delivery across cellular membranes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Biodegradable nanoparticles for drug and gene delivery to cells and tissue

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Biodegradable polyester, poly[alpha-(4-aminobutyl)-L-glycolic acid], as a non-toxic gene carrier

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

A novel biodegradable gene carrier based on polyphosphoester

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Water-soluble biodegradable cationic polyphosphazenes for gene delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Biodegradable, endosome disruptive, and cationic network-type polymer as a highly efficient and nontoxic gene delivery carrier

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Parallel Synthesis and Biophysical Characterization of a Degradable Polymer Library for Gene Delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Poly(ethylenimine-co-L-lactamide-co-succinamide): a biodegradable polyethylenimine derivative with an advantageous pH-dependent hydrolytic degradation for gene delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Degradable gene carriers based on oligomerized polyamines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Biodegradable poly(ethylenimine) for plasmid DNA delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Poly[Lys-(AEDTP)]: a cationic polymer that allows dissociation of pDNA/cationic polymer complexes in a reductive medium and enhances polyfection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Polymer side-chain degradation as a tool to control the destabilization of polyplexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Methacrylamide polymers with hydrolysis-sensitive cationic side groups as degradable gene carriers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Endosomolysis by masking of a membrane-active agent (EMMA) for cytoplasmic release of macromolecules

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

A dimethylmaleic acid-melittin-polylysine conjugate with reduced toxicity, pH-triggered endosomolytic activity and enhanced gene transfer potential

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Bioinspired pH-responsive polymers for the intracellular delivery of biomolecular drugs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

pH-responsive shielding of non-viral gene vectors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

An acetal-based PEGylation reagent for pH-sensitive shielding of DNA polyplexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

pH-responsive Multi-PEGylated dual cationic nanoparticles enable charge modulations for safe gene delivery.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

pH-responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol) conjugate through acid-labile beta-thiopropionate linkage: preparation and polyion complex micelle formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide: polyion complex (PIC) micelles based on poly(ethylene glycol)-SS-oligodeoxynucleotide conjugate.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Acid-catalyzed plasmenylcholine hydrolysis and its effect on bilayer permeability: a quantitative study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Triggerable plasmalogen liposomes: improvement of system efficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Synthesis and characterization of N-acylated, pH-sensitive 'caged' aminophospholipids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Enhanced folate receptor mediated gene therapy using a novel pH-sensitive lipid formulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG--diortho ester--lipid conjugate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Cytosolic drug delivery using pH- and light-sensitive liposomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Unsaturated cationic ortho esters for endosome permeation in gene delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Design, synthesis, and characterization of pH-sensitive PEG-PE conjugates for stimuli-sensitive pharmaceutical nanocarriers: the effect of substitutes at the hydrazone linkage on the ph stability of PEG-PE conjugates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Gene transfer with poly-melittin peptides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Enhanced cytosolic delivery of plasmid DNA by a sulfhydryl-activatable listeriolysin O/protamine conjugate utilizing cellular reducing potential

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Biotin-triggered release of poly(ethylene glycol)-avidin from biotinylated polyethylenimine enhances in vitro gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Thermoresponsive polymers as gene delivery vectors: cell viability, DNA transport and transfection studies.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Thermosensitive polymers as carriers for DNA delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Gene expression control by temperature with thermo-responsive polymeric gene carriers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Transfection efficiency increases by incorporating hydrophobic monomer units into polymeric gene carriers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Photoenhancement of transfection efficiency using novel cationic lipids having a photocleavable spacer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Reversible condensation of DNA using a redox-active surfactant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Ferrocene-containing cationic lipids for the delivery of DNA: oxidation state determines transfection activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300326

7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300326

1 reference

17 August 2017

1 reference

PubMed ID

17955026