(Q36986958)

17 August 2017

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title

Insertional mutagenesis and clonal dominance: biological and statistical considerations (English)

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17 August 2017

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Fehse B

1

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PubMed ID

17972922

17 August 2017

Roeder I

series ordinal

2

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17 August 2017

1 November 2007

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17 August 2017

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17 August 2017

15

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17 August 2017

143-153

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17 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3303052

17 August 2017

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cites work

Gene therapy for human genetic disease?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Hematopoietic stem cells: the paradigmatic tissue-specific stem cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Limiting dilution analysis for estimating the frequency of hematopoietic stem cells: uncertainty and significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Evidence that the number of hematopoietic stem cells per animal is conserved in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

In vivo reversion to normal of inherited mutations in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Natural gene therapy in monozygotic twins with Fanconi anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Precision genome surgery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Meganucleases and DNA double-strand break-induced recombination: perspectives for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

An improved zinc-finger nuclease architecture for highly specific genome editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Gene therapy. The best of times, the worst of times

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Pois(s)on--it's a question of dose...

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Side effects of retroviral gene transfer into hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Radioactive antigen suicide of an anti‐DNP (2,4‐dinitrophenyl) clone. I. Recovery and escape from clonal dominance by suici resistant precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Evidence that hematopoiesis may be a stochastic process in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Strategies to expand transduced hematopoietic stem cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

The kinetics of clonal dominance in myeloproliferative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Clonality and life cycles of intestinal crypts explained by a state dependent stochastic model of epithelial stem cell organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Stem cell fate analysis revisited: interpretation of individual clone dynamics in the light of a new paradigm of stem cell organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Modulation of specific intestinal epithelial progenitors by enteric neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

The intestinal epithelial stem cell: the mucosal governor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Retroviral insertional mutagenesis: tagging cancer pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Gene therapy insertional mutagenesis insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Occurrence of leukaemia following gene therapy of X-linked SCID.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Genotoxicity of retroviral integration in hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Modelling the molecular circuitry of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Hot spots of retroviral integration in human CD34+ hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Generation of germline-competent induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Cancer stem cells: lessons from leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Cancer stem cells: an old idea--a paradigm shift

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Transcription start regions in the human genome are favored targets for MLV integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

HIV-1 integration in the human genome favors active genes and local hotspots

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Real-time definition of non-randomness in the distribution of genomic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

A clonal marker induced by mutation in mouse intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

Immunological reconstitution of sex-linked lymphopenic immunological deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

Murine leukemia induced by retroviral gene marking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

Pancytopenia as a clonal disorder of a multipotent hematopoietic stem cell

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

Clonal dominance detected in metastases but not primary tumors of retrovirally marked human breast carcinoma injected into nude mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

The continuing contribution of gene marking to cell and gene therapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

Somatic mutation, monoclonality and stochastic models of stem cell organization in the intestinal crypt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models--a conceptual approach

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

Cell migration and organization in the intestinal crypt using a lattice-free model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

M-MuLV-induced leukemogenesis: integration and structure of recombinant proviruses in tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

Redefining the common insertion site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303052

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3303052

1 reference

PubMed ID

17972922

Dimensions Publication ID

17 August 2017

0 references

1 reference

PubMed ID

17972922