(Q34665971)

3 August 2017

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title

Modelling the molecular circuitry of cancer (English)

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3 August 2017

2

Robert A Weinberg

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William C Hahn

series ordinal

1

object named as

William C Hahn

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PubMed ID

12044009

3 August 2017

language of work or name

English

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publication date

1 May 2002

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3 August 2017

Nature Reviews Cancer

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3 August 2017

2

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3 August 2017

331-341

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3 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrc795

3 August 2017

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31 March 2020

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Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

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Diversity of gene expression in adenocarcinoma of the lung

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Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

31 March 2020

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Molecular portraits of human breast tumours

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Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells

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The Hallmarks of Cancer

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Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

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Transforming activity of human tumor DNAs

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Human-tumor-derived cell lines contain common and different transforming genes

31 March 2020

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Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells

31 March 2020

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Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin

31 March 2020

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Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

31 March 2020

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Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.

31 March 2020

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Frequent Activation of c- kis as a Transforming Gene in Fibrosarcomas Induced by Methylcholanthrene

31 March 2020

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

31 March 2020

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

31 March 2020

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Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

31 March 2020

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Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ.

31 March 2020

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How many mutations are required for tumorigenesis? Implications from human cancer data

31 March 2020

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Lessons from hereditary colorectal cancer

31 March 2020

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Genetic alterations during colorectal-tumor development

31 March 2020

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Senescence as a mode of tumor suppression

31 March 2020

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Telomerase, cell immortality, and cancer

31 March 2020

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Telomerase activation, cellular immortalization and cancer

31 March 2020

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The RNA component of human telomerase

31 March 2020

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Telomerase catalytic subunit homologs from fission yeast and human

31 March 2020

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hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

31 March 2020

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Human telomerase contains evolutionarily conserved catalytic and structural subunits

31 March 2020

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Creation of human tumour cells with defined genetic elements

31 March 2020

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

31 March 2020

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Resistance of human cells to tumorigenesis induced by cloned transforming genes

31 March 2020

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Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

31 March 2020

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Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

31 March 2020

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Telomeres, telomerase and cancer

31 March 2020

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Telomere states and cell fates

31 March 2020

1 reference

Telomeres shorten during ageing of human fibroblasts

31 March 2020

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Telomere length predicts replicative capacity of human fibroblasts

31 March 2020

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Telomerase activity in human ovarian carcinoma

31 March 2020

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Specific association of human telomerase activity with immortal cells and cancer

31 March 2020

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A survey of telomerase activity in human cancer

31 March 2020

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Extension of life-span by introduction of telomerase into normal human cells

31 March 2020

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Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

31 March 2020

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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

31 March 2020

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

31 March 2020

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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

31 March 2020

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Developmental and tissue-specific regulation of mouse telomerase and telomere length

31 March 2020

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Hypervariable ultra-long telomeres in mice

31 March 2020

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

31 March 2020

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Essential role of mouse telomerase in highly proliferative organs

31 March 2020

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The INK4a/ARF network in tumour suppression

31 March 2020

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

31 March 2020

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

31 March 2020

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Role of the retinoblastoma protein in the pathogenesis of human cancer

31 March 2020

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p53, the cellular gatekeeper for growth and division

31 March 2020

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

31 March 2020

1 reference

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

31 March 2020

1 reference

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

31 March 2020

1 reference

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

31 March 2020

1 reference

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

1 reference

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

31 March 2020

1 reference

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

31 March 2020

1 reference

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

31 March 2020

1 reference

The serial cultivation of human diploid cell strains

31 March 2020

1 reference

Role of p14(ARF) in replicative and induced senescence of human fibroblasts

31 March 2020

1 reference

Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen

31 March 2020

1 reference

A role for both RB and p53 in the regulation of human cellular senescence

31 March 2020

1 reference

Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

31 March 2020

1 reference

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

31 March 2020

1 reference

Dissociation of Rb-binding and anchorage-independent growth from immortalization and tumorigenicity using SV40 mutants producing N-terminally truncated large T antigens

31 March 2020

1 reference

Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen.

31 March 2020

1 reference

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

31 March 2020

1 reference

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

31 March 2020

1 reference

Lack of replicative senescence in cultured rat oligodendrocyte precursor cells

31 March 2020

1 reference

Lack of replicative senescence in normal rodent glia

31 March 2020

1 reference

Cellular senescence: mitotic clock or culture shock?

31 March 2020

1 reference

Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages

31 March 2020

1 reference

The cat and mouse games that genes, viruses, and cells play

31 March 2020

1 reference

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

31 March 2020

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Integration of positive and negative growth signals during ras pathway activation in vivo

31 March 2020

1 reference

Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

31 March 2020

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Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

31 March 2020

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Transient excess of MYC activity can elicit genomic instability and tumorigenesis

31 March 2020

1 reference

Defects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes

31 March 2020

1 reference

Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

31 March 2020

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Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

31 March 2020

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Activated v-myc and v-ras oncogenes do not transform normal human lymphocytes

31 March 2020

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Enumeration of the simian virus 40 early region elements necessary for human cell transformation

31 March 2020

1 reference

31 March 2020

Myc activates telomerase

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Direct activation of TERT transcription by c-MYC.

31 March 2020

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Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.

31 March 2020

1 reference

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

31 March 2020

1 reference

Control of protein phosphatase 2A by simian virus 40 small-t antigen

31 March 2020

1 reference

Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells

31 March 2020

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Role of small t antigen in the acute transforming activity of SV40

31 March 2020

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The SV40 small t antigen is essential for the morphological transformation of human fibroblasts

31 March 2020

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Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

31 March 2020

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Critical role for SV40 small-t antigen in human cell transformation

31 March 2020

1 reference

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

31 March 2020

1 reference

Regulation of protein kinase cascades by protein phosphatase 2A.

31 March 2020

1 reference

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

31 March 2020

1 reference

Targeted disruption of p107: functional overlap between p107 and Rb

31 March 2020

1 reference

Mouse models of tumor development in neurofibromatosis type 1

31 March 2020

1 reference

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

31 March 2020

1 reference

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

31 March 2020

1 reference

Switching and signaling at the telomere

31 March 2020

1 reference

Mammalian telomeres end in a large duplex loop

31 March 2020

1 reference

Reversing time: origin of telomerase

31 March 2020

1 reference

A human telomeric protein

31 March 2020

1 reference

Telomeric localization of TRF2, a novel human telobox protein

31 March 2020

1 reference

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

31 March 2020

1 reference

Pot1, the putative telomere end-binding protein in fission yeast and humans

31 March 2020

1 reference

Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells

31 March 2020

1 reference

Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells

31 March 2020

1 reference

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

31 March 2020

1 reference

Human endothelial cell life extension by telomerase expression

31 March 2020

1 reference

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

31 March 2020

1 reference

Telomerase activity is sufficient to allow transformed cells to escape from crisis

31 March 2020

1 reference

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

31 March 2020

1 reference

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

31 March 2020

1 reference

Cellular transformation by SV40 large T antigen: interaction with host proteins

31 March 2020

1 reference

The role of the SV40 ST antigen in cell growth promotion and transformation

31 March 2020

1 reference

Requirement for a functional Rb-1 gene in murine development

31 March 2020

1 reference

Effects of an Rb mutation in the mouse

31 March 2020

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

31 March 2020

1 reference

Tumor spectrum analysis in p53-mutant mice

31 March 2020

1 reference

Role of the INK4a locus in tumor suppression and cell mortality.

31 March 2020

1 reference

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

31 March 2020

1 reference

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

31 March 2020

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Pten is essential for embryonic development and tumour suppression

31 March 2020

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Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

31 March 2020

1 reference

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

31 March 2020

1 reference

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

31 March 2020

1 reference

Brca2 is required for embryonic cellular proliferation in the mouse

31 March 2020

1 reference

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

31 March 2020

1 reference

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

31 March 2020

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Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

31 March 2020

1 reference

Retinal pigment epithelium abnormalities in mice with adenomatous polyposis coli gene disruption.

31 March 2020

1 reference

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

31 March 2020

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

31 March 2020

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Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

31 March 2020

1 reference

Introduction. The laboratory mouse in cancer research

31 March 2020

1 reference

Animal models of tumor-suppressor genes.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC795

1 reference

PubMed ID

12044009

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

12044009