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The INK4a/ARF network in tumour suppression
scientific article (publication date: October 2001)
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scholarly article
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Europe PubMed Central
title
The INK4a/ARF network in tumour suppression
(English)
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author name string
C J Sherr
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1
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language of work or name
English
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publication date
October 2001
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published in
Nature Reviews Molecular Cell Biology
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volume
2
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issue
10
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page(s)
731-7
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cites work
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The regulation of E2F by pRB-family proteins
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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
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Cancer cell cycles
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p53, the cellular gatekeeper for growth and division
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The complexity of p53 modulation: emerging patterns from divergent signals
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Mechanisms of p53-mediated apoptosis
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Nucleolar Arf sequesters Mdm2 and activates p53
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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.
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Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.
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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
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The p16INK4a/CDKN2A tumor suppressor and its relatives.
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The Rb/E2F pathway: expanding roles and emerging paradigms
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The INK4 family of cell cycle inhibitors in cancer
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Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression
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Distinct roles for E2F proteins in cell growth control and apoptosis
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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.
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E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.
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Role for the p53 homologue p73 in E2F-1-induced apoptosis
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Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice
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Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors
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Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
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The retinoblastoma gene family in differentiation and development.
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Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
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Growth suppression by p16ink4 requires functional retinoblastoma protein
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CDK inhibitors: positive and negative regulators of G1-phase progression
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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
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Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis
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Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d)
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Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases
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Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity
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Role of the INK4a locus in tumor suppression and cell mortality.
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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.
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1 reference
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inferred from DOI database lookup
Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
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7 January 2021
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7 January 2021
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7 January 2021
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7 January 2021
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1 reference
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https://api.crossref.org/works/10.1038%2F35096061
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7 January 2021
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inferred from DOI database lookup
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1 reference
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https://api.crossref.org/works/10.1038%2F35096061
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7 January 2021
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p14ARF links the tumour suppressors RB and p53.
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https://api.crossref.org/works/10.1038%2F35096061
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7 January 2021
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Myc requires distinct E2F activities to induce S phase and apoptosis
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7 January 2021
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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
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7 January 2021
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Twist is a potential oncogene that inhibits apoptosis
1 reference
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https://api.crossref.org/works/10.1038%2F35096061
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7 January 2021
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inferred from DOI database lookup
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.
1 reference
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https://api.crossref.org/works/10.1038%2F35096061
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7 January 2021
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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.
1 reference
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https://api.crossref.org/works/10.1038%2F35096061
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7 January 2021
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inferred from DOI database lookup
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
1 reference
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https://api.crossref.org/works/10.1038%2F35096061
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7 January 2021
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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35096061
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p53-independent functions of the p19(ARF) tumor suppressor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35096061
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7 January 2021
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Identifiers
DOI
10.1038/35096061
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
564570
Dimensions Publication ID
1028410796
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OpenCitations bibliographic resource ID
564570
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
564570
PubMed publication ID
11584300
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
564570
ResearchGate publication ID
11765836
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