(Q54021692)

23 May 2018

title

Escape from premature senescence is not sufficient for oncogenic transformation by Ras. (English)

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23 May 2018

author

René Bernards

5

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23 May 2018

author name string

Peeper DS

1

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23 May 2018

Dannenberg JH

2

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23 May 2018

Douma S

3

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23 May 2018

te Riele H

4

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23 May 2018

publication date

1 February 2001

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23 May 2018

published in

Nature Cell Biology

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23 May 2018

volume

3

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23 May 2018

page(s)

198-203

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23 May 2018

issue

2

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23 May 2018

https://scigraph.springernature.com/pub.10.1038/35055110

exact match

0 references

cites work

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In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes.

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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Ras-induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

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p107 is a suppressor of retinoblastoma development in pRb-deficient mice

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p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

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7 January 2021

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs

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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

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Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells.

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Distinct roles for cyclin-dependent kinases in cell cycle control

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7 January 2021

Identifiers

DOI

10.1038/35055110

1 reference

23 May 2018

PubMed ID

11175753

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23 May 2018