(Q34132858)

31 July 2017

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title

Cellular senescence as a tumor-protection mechanism: the essential role of counting (English)

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31 July 2017

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1

Wright WE

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31 July 2017

Shay JW

2

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31 July 2017

1 February 2001

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Current Opinion in Genetics & Development

31 July 2017

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31 July 2017

11

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31 July 2017

98-103

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31 July 2017

1

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The serial cultivation of human diploid cell strains

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Evidence for a new step in telomere maintenance

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https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

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https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Telomere reduction in human colorectal carcinoma and with ageing

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

In vivo loss of telomeric repeats with age in humans

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https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Telomeres shorten during ageing of human fibroblasts

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https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

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https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Creation of human tumour cells with defined genetic elements

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Transient expression of human telomerase extends the life span of normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Cellular senescence: mitotic clock or culture shock?

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https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Human endothelial cell life extension by telomerase expression

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Inactivation of p16 in human mammary epithelial cells by CpG island methylation

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https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Positive correlation between mammalian life span and cellular resistance to stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

The effect of low oxygen tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Atm-deficient mice: a paradigm of ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Extended culture of mouse embryo cells without senescence: inhibition by serum.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

The relationships of animal age and caloric intake to cellular replication in vivo and in vitro: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Mitotic misregulation and human aging

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Phospholipase D in cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900163-5

7 January 2021

10.1016/S0959-437X(00)00163-5

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11163158