(Q37000556)

English

An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R.

scientific article published on 21 May 2013

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R. (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1 reference

based on heuristic

inferred from title

Machelle Wilson

object named as

Machelle D Wilson

10

0 references

Yoshikazu Takada

object named as

Yoshikazu Takada

14

0 references

Anthony T. W. Cheung

9

object named as

Anthony T W Cheung

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

11

object named as

Robert D Cardiff

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Masaaki Fujita

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Katsuaki Ieguchi

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Dora M Cedano-Prieto

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Andrew Fong

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Charles Wilkerson

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Jane Q Chen

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Mac Wu

7

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Su-Hao Lo

8

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Alexander D Borowsky

12

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Yoko K Takada

13

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

0 references

publication date

21 May 2013

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

number of pages

11

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

288

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

27

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

19593-19603

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1-IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Cross-talk between integrin α6β4 and insulin-like growth factor-1 receptor (IGF1R) through direct α6β4 binding to IGF1 and subsequent α6β4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

IGF system in cancer: from bench to clinic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Integrins: bidirectional, allosteric signaling machines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

The IGF system in thyroid cancer: new concepts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

9 September 2017

IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

29 September 2017

Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

29 September 2017

Cell migration: interactions among integrins, IGFs and IGFBPs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

29 September 2017

A microplate assay for quantitation of anchorage-independent growth of transformed cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

29 September 2017

Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

4 September 2018

The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

4 September 2018

Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707660

4 September 2018

Microcirculation and metastasis in a new mouse mammary tumor model system

1 reference

https://pubmed.ncbi.nlm.nih.gov/23696648

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9

1 reference

https://pubmed.ncbi.nlm.nih.gov/23696648

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23696648

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.470872

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

release_2d4ryfpfhvgj7mnllypb5zt3ou

1 reference

https://api.fatcat.wiki/v0/release/2d4ryfpfhvgj7mnllypb5zt3ou

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q37000556&oldid=2137786300"