(Q37003645)

17 August 2017

Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice (English)

1 reference

17 August 2017

multiple drug resistance

1 reference

Xianbin Tian

1

1 reference

17 August 2017

Maciej J Zamek-Gliszczynski

2

1 reference

17 August 2017

Jun Li

3

1 reference

17 August 2017

Arlene S Bridges

4

1 reference

17 August 2017

Ken-ichi Nezasa

5

1 reference

17 August 2017

Nita J Patel

6

1 reference

17 August 2017

Thomas J Raub

7

1 reference

17 August 2017

Kim L R Brouwer

8

1 reference

17 August 2017

3 October 2007

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Drug Metabolism and Disposition

17 August 2017

1 reference

17 August 2017

36

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17 August 2017

1

1 reference

17 August 2017

61-64

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Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

Functional analysis of dog multidrug resistance-associated protein 2 (Mrp2) in comparison with rat Mrp2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597637

The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice

4 September 2018

1 reference

12 December 2020

Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice

1 reference

12 December 2020

Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice

1 reference

12 December 2020

Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics

1 reference

12 December 2020

Identifiers

DOI

10.1124/DMD.107.017319

1 reference

17 August 2017

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17 August 2017

PubMed publication ID

17913796

1 reference