(Q37004748)

English

Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway

scientific article published on December 2007

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scholarly article

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway (English)

1 reference

Europe PubMed Central

17 August 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

lessons learned

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based on heuristic

inferred from title

author name string

Zhijie Li

1

1 reference

Europe PubMed Central

17 August 2017

Carol J Thiele

2

1 reference

Europe PubMed Central

17 August 2017

language of work or name

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publication date

1 December 2007

1 reference

Europe PubMed Central

17 August 2017

Expert Opinion on Therapeutic Targets

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Europe PubMed Central

17 August 2017

11

1 reference

Europe PubMed Central

17 August 2017

12

1 reference

Europe PubMed Central

17 August 2017

1611-1621

1 reference

Europe PubMed Central

17 August 2017

Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Biology and genetics of human neuroblastomas.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Neurotrophin signalling pathways regulating neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Growth and survival signals controlling sympathetic nervous system development

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Embryonic sympathoblasts transiently express TrkB in vivo and proliferate in response to brain-derived neurotrophic factor in vitro

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Neuroblastoma: biological insights into a clinical enigma

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

A BDNF autocrine loop in adult sensory neurons prevents cell death.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Brain derived neurotrophic factor protects human neuroblastoma cells from DNA damaging agents

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Brain-derived neurotrophic factor promotes survival and chemoprotection of human neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Cisplatin-induced cytotoxicity is blocked by brain-derived neurotrophic factor activation of TrkB signal transduction path in neuroblastoma

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Trk receptors: mediators of neurotrophin action

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Effect of CEP-751 (KT-6587) on neuroblastoma xenografts expressing TrkB.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Involvement of extracellular signal-regulated kinases 1/2 and (phosphoinositide 3-kinase)/Akt signal pathways in acquired resistance against neurotoxin of 6-hydroxydopamine in SH-SY5Y cells following cell-cell interaction with astrocytes

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth, downregulates phosphorylated Akt, and increases sensitivity to doxorubicin

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Protein kinase B modulates the sensitivity of human neuroblastoma cells to insulin-like growth factor receptor inhibition.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Mitogenic and apoptotic actions of epidermal growth factor on neuroblastoma cells are concentration-dependent

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Proliferation of human neuroblastomas mediated by the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

RNA interference targeting Akt promotes apoptosis in hypoxia-exposed human neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Activation of Akt predicts poor outcome in neuroblastoma

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid

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21 January 2018

Phase II study of daily oral perifosine in patients with advanced soft tissue sarcoma.

1 reference

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21 January 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1611

21 January 2018

Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

1 reference

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21 January 2018

HIV-1 protease inhibitors. A review for clinicians

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21 January 2018

Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study

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21 January 2018

Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir

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21 January 2018

HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma

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21 January 2018

HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling

1 reference

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21 January 2018

HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo

1 reference

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21 January 2018

NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines

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21 January 2018

Identifiers

10.1517/14728222.11.12.1611

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

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