(Q37008509)

17 August 2017

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title

Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia (English)

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17 August 2017

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Ralph V Shohet

1

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17 August 2017

Joseph A Garcia

series ordinal

2

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17 August 2017

publication date

20 November 2007

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Journal of Molecular Medicine

17 August 2017

published in

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17 August 2017

volume

85

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17 August 2017

issue

12

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17 August 2017

page(s)

1309-1315

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https://scigraph.springernature.com/pub.10.1007/s00109-007-0279-x

17 August 2017

exact match

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cites work

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Elevated expression of hexokinase II protects human lung epithelial-like A549 cells against oxidative injury

21 January 2018

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Gene expression profiles in human cardiac cells subjected to hypoxia or expressing a hybrid form of HIF-1 alpha.

21 January 2018

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Occurrence of oxidative stress during reperfusion of the human heart

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Antioxidants in myocardial ischemia-reperfusion injury: therapeutic potential and basic mechanisms

21 January 2018

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12 December 2020

Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury

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Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse

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Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart

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HIF-1 and human disease: one highly involved factor

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12 December 2020

Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.

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12 December 2020

Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium

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12 December 2020

The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion,

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12 December 2020

Myocardial utilization of carbohydrate and lipids

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12 December 2020

Hypoxia inhibits the peroxisome proliferator-activated receptor alpha/retinoid X receptor gene regulatory pathway in cardiac myocytes: a mechanism for O2-dependent modulation of mitochondrial fatty acid oxidation

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12 December 2020

Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney.

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12 December 2020

A "second window of protection" or delayed preconditioning phenomenon: future horizons for myocardial protection?

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Reactive oxygen species function as second messenger during ischemic preconditioning of heart

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12 December 2020

Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development.

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12 December 2020

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

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12 December 2020

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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12 December 2020

Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease

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12 December 2020

Assessment of myocardial oxidative stress in patients after myocardial revascularization

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12 December 2020

Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling

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12 December 2020

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system

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12 December 2020

Ischemia-reperfusion and cardioprotection: a delicate balance between reactive oxygen species generation and redox homeostasis

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12 December 2020

Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat.

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12 December 2020

Cardiac ischemia/reperfusion, aging, and redox-dependent alterations in mitochondrial function

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12 December 2020

Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors

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12 December 2020

Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development

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12 December 2020

Early expression of angiogenesis factors in acute myocardial ischemia and infarction

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12 December 2020

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

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12 December 2020

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

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12 December 2020

Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin

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12 December 2020

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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12 December 2020

Immunohistochemical expression of HIF-1alpha in response to early myocardial ischemia

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12 December 2020

Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury

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12 December 2020

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.

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12 December 2020

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

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12 December 2020

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

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12 December 2020

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

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12 December 2020

Metabolic and genetic regulation of cardiac energy substrate preference

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12 December 2020

The role of mitochondria in protection of the heart by preconditioning.

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12 December 2020

The mitochondrial biogenesis regulatory program in cardiac adaptation to ischemia--a putative target for therapeutic intervention

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12 December 2020

A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha

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12 December 2020

The mitochondrial antioxidant defence system and its response to oxidative stress.

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12 December 2020

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury

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12 December 2020

Endothelium-intrinsic requirement for Hif-2alpha during vascular development

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12 December 2020

Heart mitochondria signaling pathways: appraisal of an emerging field

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12 December 2020

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12 December 2020

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12 December 2020

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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12 December 2020

Regulation of antioxidant enzymes 1

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12 December 2020

Differential levels of tissue hypoxia in the developing chicken heart

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12 December 2020

The expanding network of redox signaling: new observations, complexities, and perspectives

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12 December 2020

Gene Expression during Myocardial Adaptation to Ischemia and Reperfusion a.

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12 December 2020

Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity

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12 December 2020

Myocardial ischemia-reperfusion injury, antioxidant enzyme systems, and selenium: a review

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12 December 2020

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

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12 December 2020

Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart

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12 December 2020

Human ventricular myocytes in vitro exhibit both early and delayed preconditioning responses to simulated ischemia.

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12 December 2020

Substrate-utilization of the Human Kidney

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12 December 2020

Antioxidant and redox regulation of gene transcription

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12 December 2020

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

1 reference

12 December 2020

A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.

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12 December 2020

Detection of hydroxyl radical in the mitochondria of ischemic-reperfused myocardium by trapping with salicylate

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12 December 2020

Hypoxia inducible factor-1 expression mediates myocardial response to ischemia late after acute myocardial infarction

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12 December 2020

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

12 December 2020

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

12 December 2020

Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis.

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12 December 2020

Metabolism--the lost child of cardiology

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12 December 2020

Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.

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12 December 2020

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

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12 December 2020

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

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12 December 2020

10.1007/S00109-007-0279-X

Identifiers

DOI

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17 August 2017

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