(Q37008855)

17 August 2017

1 reference

title

Macrophage peroxisome proliferator activated receptor gamma as a therapeutic target to combat Type 2 diabetes (English)

1 reference

17 August 2017

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Gabriel Pascual

1

1 reference

17 August 2017

Mercedes Ricote

series ordinal

2

1 reference

17 August 2017

Andrea L Hevener

series ordinal

3

1 reference

17 August 2017

language of work or name

English

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publication date

1 November 2007

1 reference

Expert Opinion on Therapeutic Targets

17 August 2017

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17 August 2017

11

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17 August 2017

11

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17 August 2017

1503-1520

1 reference

Pathogenesis of NIDDM. A balanced overview

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Role of insulin resistance in human disease (syndrome X): an expanded definition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Metabolic syndrome: definition, pathophysiology, and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Increasing prevalence of the metabolic syndrome among u.s. Adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Inflammatory status and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Inflammation in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

A cytokine-mediated link between innate immunity, inflammation, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

IKK-beta links inflammation to obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Obesity is associated with macrophage accumulation in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Endocrinology of adipose tissue - an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Inflammation and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

The organization, promoter analysis, and expression of the human PPARgamma gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

PPAR gamma is required for placental, cardiac, and adipose tissue development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Troglitazone action is independent of adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Muscle-specific Pparg deletion causes insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Controlling nuclear receptors: the circular logic of cofactor cycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

15d-PGJ2: the anti-inflammatory prostaglandin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Mechanism of the nuclear receptor molecular switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

PPAR(gamma) and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Insulin resistance/compensatory hyperinsulinemia predict carotid intimal medial thickness in patients with essential hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

TLR4 links innate immunity and fatty acid-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Increased CD36 protein as a response to defective insulin signaling in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

The macrophage at the crossroads of insulin resistance and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

The adipocyte-myocyte axis in insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Cellular inflammatory responses: novel insights for obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Resistin release by human adipose tissue explants in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Monocyte chemoattractant protein 1 in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Alternative activation of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

The many faces of macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Impaired interleukin 4 signaling in T helper type 1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Diabetes mellitus and genetically programmed defects in beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Pioglitazone induces apoptosis of macrophages in human adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Selective PPARgamma modulators with improved pharmacological profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1503

10.1517/14728222.11.11.1503

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference