(Q34290627)

English

Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

apoptotic process

0 references

0 references

Dominic J Withers

object named as

Dominic J Withers

2

0 references

Michael J Grusby

5

object named as

Michael J Grusby

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

author name string

Andrea L Wurster

1

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Tohru Uchida

3

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Morris F White

4

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

language of work or name

0 references

publication date

1 January 2002

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

22

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

117-126

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

The biology of Stat4 and Stat6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Induction of NF-kappaB by the Akt/PKB kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Regulation of immune responses through inhibitory receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

The IL-4 receptor: signaling mechanisms and biologic functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Interleukin 4: signalling mechanisms and control of T cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Akt signaling: linking membrane events to life and death decisions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Essential role of Stat6 in IL-4 signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

An interleukin-4-induced transcription factor: IL-4 Stat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Inactivation of Bcl-2 by phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Role of IRS-2 in insulin and cytokine signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

6 July 2018

Cytokine-stimulated T lymphocyte proliferation is regulated by p27Kip1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

28 October 2018

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

28 October 2018

Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134231

28 October 2018

IRS-2 pathways integrate female reproduction and energy homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor alpha chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 induces Fas resistance in B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4 (IL-4) induces phosphatidylinositol 3-kinase (p85) dephosphorylation. Implications for the role of SHP-1 in the IL-4-induced signals in human B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine phosphatase activity is required for IL-4 induction of IL-4 receptor alpha-chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739727

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.22.1.117-126.2002

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34290627&oldid=2060146797"