(Q37017307)

English

Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility

scientific article published on 19 June 2013

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23746196%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23746196%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

8

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2 March 2020

author name string

Chunyong Ding

1

1 reference

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2 March 2020

Yusong Zhang

2

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2 March 2020

Haijun Chen

3

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2 March 2020

Zhengduo Yang

4

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2 March 2020

Christopher Wild

5

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2 March 2020

Lili Chu

6

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2 March 2020

Huiling Liu

7

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2 March 2020

Jia Zhou

9

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2 March 2020

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publication date

19 June 2013

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2 March 2020

Journal of Medicinal Chemistry

1 reference

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2 March 2020

56

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2 March 2020

12

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2 March 2020

5048-5058

1 reference

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2 March 2020

Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Natural products as sources of new drugs over the 30 years from 1981 to 2010

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Natural products: an evolving role in future drug discovery.

1 reference

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29 September 2017

7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents

1 reference

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29 September 2017

Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

1 reference

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29 September 2017

Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents.

1 reference

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29 September 2017

Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Impact of natural products on developing new anti-cancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Natural products as leads to potential drugs: an old process or the new hope for drug discovery?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Preclinical discovery of ixabepilone, a highly active antineoplastic agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Diterpenoids from Isodon species and their biological activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

New developments in natural products-based anti-AIDS research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Augmentation of oridonin-induced apoptosis observed with reduced autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Drug-like properties and the causes of poor solubility and poor permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Structure optimization of a leukotriene D4 antagonist by combinatorial chemistry in solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

29 September 2017

Instability of succinyl ester linkages in O2'-monosuccinyl cyclic AMP-protein conjugates at neutral pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

27 June 2018

Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

4 September 2018

ent-Kaurane Diterpenoids from Isodon albopilosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

4 September 2018

The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage.

1 reference

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4 September 2018

2-aminothiazole-derived opioids. Bioisosteric replacement of phenols.

1 reference

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4 September 2018

Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3712786

4 September 2018

The antitumor and antibacterial activity of the Isodon diterpenoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746196

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of acylated oridonin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746196

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of diterpenoids, trichorabdals A, B, and C, and the related compounds: synergism of two active sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746196

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medicine from plants

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746196

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746196

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746196

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of rabdosia rubescens in the treatment of gingivitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23746196

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM400367N

1 reference

Europe PubMed Central

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2 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23746196%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23746196%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

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