(Q37024025)

17 August 2017

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title

Radiation-induced EGFR-signaling and control of DNA-damage repair (English)

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17 August 2017

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H Peter Rodemann

1

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17 August 2017

Klaus Dittmann

series ordinal

2

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17 August 2017

Mahmoud Toulany

series ordinal

3

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17 August 2017

publication date

1 November 2007

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International Journal of Radiation Biology

17 August 2017

published in

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17 August 2017

volume

83

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17 August 2017

issue

11-12

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17 August 2017

page(s)

781-791

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EGFR overexpression and radiation response in glioblastoma multiforme

17 August 2017

cites work

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EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms

21 January 2018

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Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking

21 January 2018

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Nuclear localization and possible functions of receptor tyrosine kinases

21 January 2018

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Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.

21 January 2018

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K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.

21 January 2018

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Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

The role of individual SH2 domains in mediating association of phospholipase C-gamma1 with the activated EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

21 January 2018

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New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Stress and radiation-induced activation of multiple intracellular signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Mechanisms controlling EGF receptor endocytosis and degradation

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy

21 January 2018

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Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathways

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Co-regulation of B-Myb expression by E2F1 and EGF receptor

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Ku70/80 gene expression and DNA-dependent protein kinase (DNA-PK) activity do not correlate with double-strand break (dsb) repair capacity and cellular radiosensitivity in normal human fibroblasts.

21 January 2018

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https://api.crossref.org/works/10.1080%2F09553000701769970

Huge differences in cellular radiosensitivity due to only very small variations in double-strand break repair capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: differential response of cancer stem cells and nontumourigenic cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Combination treatment significantly enhances the efficacy of antitumor therapy by preferentially targeting angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Nuclear localization of EGF receptor and its potential new role as a transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Signal transduction in fibroblasts stably transformed by [Val12]Ras--the activities of extracellular-signal-regulated kinase and Jun N-terminal kinase are only moderately increased, and the activity of the delta-inhibitor of c-Jun is not alleviated

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Targeting BRAF in thyroid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

RAS transformation causes sustained activation of epidermal growth factor receptor and elevation of mitogen-activated protein kinase in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

The RAS signal transduction pathway and its role in radiation sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Caveolae/raft-dependent endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

The protein kinase B/Akt signalling pathway in human malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

c-erbB-3: a nuclear protein in mammary epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Human and rodent cell lines showing no differences in the induction but differing in the repair kinetics of radiation-induced DNA base damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor-related peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

The activation of Akt/PKB signaling pathway and cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Internalization of the epidermal growth factor receptor: role in signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

The association between Akt activation and resistance to hormone therapy in metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Tyrosine phosphorylation controls PCNA function through protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Radiotherapy-induced signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701769970

10.1080/09553000701769970

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference