(Q37028982)

17 August 2017

3 references

3 July 2022

22 August 2022

Human monoclonal antibodies from transgenic mice (English)

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17 August 2017

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Lonberg N

1

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17 August 2017

publication date

1 January 2008

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Handbook of experimental pharmacology

17 August 2017

published in

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17 August 2017

3 July 2022

22 August 2022

181

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17 August 2017

page(s)

69-97

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Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.

17 August 2017

cites work

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12 December 2020

Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma

1 reference

12 December 2020

Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus.

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12 December 2020

Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors

1 reference

12 December 2020

A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis

1 reference

12 December 2020

A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women

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12 December 2020

Randomized phase III trial results of panitumumab, a fully human anti-epidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancer

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12 December 2020

Phage antibodies: filamentous phage displaying antibody variable domains

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12 December 2020

Prospects for the therapeutic use of human monoclonal antibodies

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12 December 2020

HuMax-CD4: a fully human monoclonal anti-CD4 antibody for the treatment of psoriasis vulgaris.

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12 December 2020

Combination of the human anti-CD30 antibody 5F11 with cytostatic drugs enhances its antitumor activity against Hodgkin and anaplastic large cell lymphoma cell lines

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12 December 2020

Effect of Target Dynamics on Pharmacokinetics of a Novel Therapeutic Antibody against the Epidermal Growth Factor Receptor: Implications for the Mechanisms of Action

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12 December 2020

Continuous cultures of fused cells secreting antibody of predefined specificity

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12 December 2020

Rituximab (anti-CD20 monoclonal antibody) for the treatment of patients with relapsing or refractory aggressive lymphoma: a multicenter phase II study

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12 December 2020

Isolation and characterization of human monoclonal antibodies to digoxin

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12 December 2020

Preparation of human IgG and IgM monoclonal antibodies for MK-1/Ep-CAM by using human immunoglobulin gene-transferred mouse and gene cloning of their variable regions

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12 December 2020

Production of human monoclonal and polyclonal antibodies in TransChromo animals

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12 December 2020

Structure-function relationships for human antibodies to pneumococcal capsular polysaccharide from transgenic mice with human immunoglobulin Loci

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12 December 2020

Human antibodies from transgenic mice

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12 December 2020

Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma

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12 December 2020

Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice

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12 December 2020

Activity and safety of CTLA-4 blockade combined with vaccines in cynomolgus macaques

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12 December 2020

Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

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12 December 2020

The evolutionary and structural 'logic' of antigen receptor diversity

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12 December 2020

Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity

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12 December 2020

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model

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12 December 2020

Human monoclonal antibodies produced in transgenic BABkappa,lambda mice recognising idiotypic immunoglobulins of human lymphoma cells

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12 December 2020

Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes.

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12 December 2020

The fully human anti-CD30 antibody 5F11 activates NF-{kappa}B and sensitizes lymphoma cells to bortezomib-induced apoptosis

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12 December 2020

Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal.

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12 December 2020

Production and characterization of protective human antibodies against Shiga toxin 1

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12 December 2020

Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4

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12 December 2020

Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

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12 December 2020

Human monoclonal antibody production. Current status and future prospects

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12 December 2020

Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice

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12 December 2020

Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy

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12 December 2020

Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer

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12 December 2020

Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma

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12 December 2020

Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable angina. European Cooperative Study Group

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12 December 2020

Human Stx2-specific monoclonal antibodies prevent systemic complications of Escherichia coli O157:H7 infection

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12 December 2020

Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206.

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12 December 2020

Immunotherapy of Hodgkin's lymphoma

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12 December 2020

Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes

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12 December 2020

Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma

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12 December 2020

Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer

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12 December 2020

Denosumab in postmenopausal women with low bone mineral density

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12 December 2020

Role of dendritic cell phenotype, determinant spreading, and negative costimulatory blockade in dendritic cell-based melanoma immunotherapy

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12 December 2020

Immunogenicity, efficacy and adverse events of adalimumab in RA patients

1 reference

12 December 2020

Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial

1 reference

12 December 2020

Bioimmunotherapy for melanoma using fully human antibodies targeting MCAM/MUC18 and IL-8.

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12 December 2020

Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies

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12 December 2020

The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.

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12 December 2020

Will immunogenicity limit the use, efficacy, and future development of therapeutic monoclonal antibodies?

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12 December 2020

Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody

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12 December 2020

A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis

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12 December 2020

Anti-endotoxin human monoclonal antibody A6H4C5 (HA-1A) utilizes the VH4.21 gene

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12 December 2020

PSMA specific antibodies and their diagnostic and therapeutic use.

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12 December 2020

Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy

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12 December 2020

Differential effects of administration of a human anti-CD4 monoclonal antibody, HM6G, in nonhuman primates

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12 December 2020

A human immunoglobulin lambda locus is similarly well expressed in mice and humans

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12 December 2020

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

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12 December 2020

Germ-line transmission and expression of a human-derived yeast artificial chromosome

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12 December 2020

An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis.

1 reference

12 December 2020

Human antibody against shiga toxin 2 administered to piglets after the onset of diarrhea due to Escherichia coli O157:H7 prevents fatal systemic complications

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12 December 2020

Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2

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12 December 2020

The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20.

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12 December 2020

Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs

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12 December 2020

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

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12 December 2020

A Phase I Study Evaluating the Safety, Pharmacokinetics, and Clinical Response of a Human IL-12 p40 Antibody in Subjects with Plaque Psoriasis

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12 December 2020

Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice

1 reference

12 December 2020

On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2

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12 December 2020

The human anti-CD30 antibody 5F11 shows in vitro and in vivo activity against malignant lymphoma

1 reference

12 December 2020

Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma

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12 December 2020

A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice.

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12 December 2020

Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease

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12 December 2020

Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells

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12 December 2020

Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy

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12 December 2020

Class switching in human immunoglobulin transgenic mice

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12 December 2020

Human monoclonal antibodies directed against toxins A and B prevent Clostridium difficile-induced mortality in hamsters

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12 December 2020

Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.

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12 December 2020

Kinetic and affinity limits on antibodies produced during immune responses

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12 December 2020

Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody

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12 December 2020

Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study

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12 December 2020

A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer

1 reference

12 December 2020

Anti-lipid A monoclonal antibody centoxin (HA-1A) binds to a wide variety of hydrophobic ligands

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12 December 2020

Cell-type-specific and regulated expression of a human gamma 1 heavy-chain immunoglobulin gene in transgenic mice

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12 December 2020

Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles

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12 December 2020

Functional expression and germline transmission of a human chromosome fragment in chimaeric mice

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12 December 2020

Integration and Stable Germ Line Transmission of Genes Injected into Mouse Pronuclei

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12 December 2020

Absence of adverse effects in cynomolgus macaques treated with CNTO 95, a fully human anti-alphav integrin monoclonal antibody, despite widespread tissue binding

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12 December 2020

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.

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12 December 2020

Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines

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12 December 2020

The creation of diversity in the human immunoglobulin V(lambda) repertoire

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12 December 2020

Fully human anti-interleukin-8 monoclonal antibodies: potential therapeutics for the treatment of inflammatory disease states

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12 December 2020

High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice

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12 December 2020

Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB.

1 reference

12 December 2020

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

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12 December 2020

Immunogenicity of therapeutic monoclonal antibodies

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12 December 2020

Antibody therapy in the management of shiga toxin-induced hemolytic uremic syndrome

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12 December 2020

Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers

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12 December 2020

Rearrangement and expression of rabbit immunoglobulin kappa light chain gene in transgenic mice

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12 December 2020

A method for the generation of YAC transgenic mice by pronuclear microinjection

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12 December 2020

Efficient isolation of novel human monoclonal antibodies with neutralizing activity against HIV-1 from transgenic mice expressing human Ig loci

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12 December 2020

Identification of a novel prostate tumor target, mindin/RG-1, for antibody-based radiotherapy of prostate cancer

1 reference

12 December 2020

Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate-specific membrane antigen

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12 December 2020

Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis

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12 December 2020

Monoclonal antibody-based immunotherapy of Hodgkin's lymphoma.

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12 December 2020

HMMC-1: a humanized monoclonal antibody with therapeutic potential against Müllerian duct-related carcinomas

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12 December 2020

Human antibodies from transgenic animals

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12 December 2020

Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS Trial Study Group.

1 reference

12 December 2020

Generation, immunologic characterization and antitumor effects of human monoclonal antibodies for carcinoembryonic antigen

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12 December 2020

Anti-interleukin-12 antibody for active Crohn's disease

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12 December 2020

Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer

1 reference

12 December 2020

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

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12 December 2020

Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome

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12 December 2020

Germ line transmission of a yeast artificial chromosome spanning the murine alpha 1(I) collagen locus

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12 December 2020

Antibody producing human-human hybridomas. II. Derivation and characterization of an antibody specific for human leukemia cells

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12 December 2020

The HA-1A saga: the scientific and ethical dilemma of innovative and costly therapies.

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12 December 2020

Clinical experience with monoclonal antibodies to epidermal growth factor receptor

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12 December 2020

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains

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12 December 2020

Prophylaxis and therapy of inhalational anthrax by a novel monoclonal antibody to protective antigen that mimics vaccine-induced immunity

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12 December 2020

Current treatment and immunotherapy of Hodgkin's lymphoma.

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12 December 2020

Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks

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12 December 2020

Anti-vascular endothelial growth factor receptor-1 antagonist antibody as a therapeutic agent for cancer

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12 December 2020

A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants

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12 December 2020

Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade

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12 December 2020

HMOCC-1, a human monoclonal antibody that inhibits adhesion of ovarian cancer cells to human mesothelial cells

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12 December 2020

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

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12 December 2020

Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies

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12 December 2020

A repertoire of monoclonal antibodies with human heavy chains from transgenic mice

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12 December 2020

Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

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12 December 2020

Antigen-specific human antibodies from mice comprising four distinct genetic modifications

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12 December 2020

A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins

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12 December 2020

Mannose receptor targeting of tumor antigen pmel17 to human dendritic cells directs anti-melanoma T cell responses via multiple HLA molecules

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12 December 2020

Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma

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12 December 2020

Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities

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12 December 2020

Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

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12 December 2020

Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation

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12 December 2020

Skin reactions in a subset of patients with stage IV melanoma treated with anti-cytotoxic T-lymphocyte antigen 4 monoclonal antibody as a single agent

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12 December 2020

Checkpoint blockade in cancer immunotherapy

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12 December 2020

Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanoma

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12 December 2020

In situ depletion of CD4+ T cells in human skin by Zanolimumab

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12 December 2020

Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring

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12 December 2020

Panitumumab the first fully human monoclonal antibody: from the bench to the clinic

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12 December 2020

Replacing the complementarity-determining regions in a human antibody with those from a mouse

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12 December 2020

Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse

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12 December 2020

The Imprint of Somatic Hypermutation on the Repertoire of Human Germline V Genes

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12 December 2020

Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

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12 December 2020

CNTO 95, a fully human monoclonal antibody that inhibits alphav integrins, has antitumor and antiangiogenic activity in vivo

1 reference

12 December 2020

A phase I trial of an interleukin-12/23 monoclonal antibody in relapsing multiple sclerosis

1 reference

12 December 2020

CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma

1 reference

12 December 2020

Introduction of a rabbit beta-globin gene into the mouse germ line

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12 December 2020

Demonstration of an in vivo generated sub-picomolar affinity fully human monoclonal antibody to interleukin-8.

1 reference

12 December 2020

Enhancement of antitumor immunity by CTLA-4 blockade

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12 December 2020

10.1007/978-3-540-73259-4_4

Identifiers

DOI

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PMC publication ID

7120671

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