(Q37039704)

English

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets.

scientific article published on 03 May 2016

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scholarly article

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Europe PubMed Central

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18 March 2020

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets (English)

1 reference

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18 March 2020

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18 March 2020

8

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18 March 2020

author name string

Michael R DiGruccio

1

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18 March 2020

Cynthia J Donaldson

3

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18 March 2020

Glyn M Noguchi

4

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18 March 2020

Joan Vaughan

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18 March 2020

Christopher Cowing-Zitron

6

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18 March 2020

Talitha van der Meulen

7

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18 March 2020

language of work or name

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3 May 2016

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18 March 2020

Molecular Metabolism

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18 March 2020

5

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18 March 2020

7

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18 March 2020

449-458

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18 March 2020

Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Ghrelin signalling in β-cells regulates insulin secretion and blood glucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

The diabetes gene Hhex maintains δ-cell differentiation and islet function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

1 reference

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29 September 2017

Ultrasensitive fluorescent proteins for imaging neuronal activity

1 reference

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29 September 2017

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Novel function of transthyretin in pancreatic alpha cells.

1 reference

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29 September 2017

STAR: ultrafast universal RNA-seq aligner

1 reference

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29 September 2017

Paracrine and autocrine interactions in the human islet: more than meets the eye

1 reference

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29 September 2017

Guide to Receptors and Channels (GRAC), 5th edition

1 reference

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29 September 2017

A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Ghrelin directly stimulates glucagon secretion from pancreatic alpha-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

MafA and MafB regulate genes critical to beta-cells in a unique temporal manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

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29 September 2017

SST3-selective potent peptidic somatostatin receptor antagonists

1 reference

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29 September 2017

A receptor in pituitary and hypothalamus that functions in growth hormone release

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29 September 2017

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

1 reference

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29 September 2017

Biologic and immunologic activities and applications of somatostatin analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Interaction of somatostatin with the A and B cells of the endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

29 September 2017

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

27 June 2018

Exocytosis of insulin: in vivo maturation of mouse endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

27 June 2018

Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

27 June 2018

The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

27 June 2018

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

4 September 2018

Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

4 September 2018

Dose-dependent inhibition by ghrelin of insulin secretion in the mouse

1 reference

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4 September 2018

Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921781

4 September 2018

Interrelationship of glucagon, insulin and glucose. The insulinogenic effect of glucagon

1 reference

https://pubmed.ncbi.nlm.nih.gov/27408771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon

1 reference

https://pubmed.ncbi.nlm.nih.gov/27408771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl

1 reference

https://pubmed.ncbi.nlm.nih.gov/27408771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PROMOTION OF INSULIN SECRETION BY GLUCAGON

1 reference

https://pubmed.ncbi.nlm.nih.gov/27408771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological activity of somatostatin and somatostatin analogs on inhibtion of arginine-induced insulin and glucagon release in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/27408771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphological analysis of ghrelin and its receptor distribution in the rat pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/27408771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet amyloid polypeptide gene expression in the endocrine pancreas of the rat: a combined in situ hybridization and immunocytochemical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/27408771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

1 reference

https://pubmed.ncbi.nlm.nih.gov/27408771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MOLMET.2016.04.007

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408771%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

release_gr7blqxo5bcsddyclfrqftwd7u

1 reference

https://api.fatcat.wiki/v0/release/gr7blqxo5bcsddyclfrqftwd7u

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408771%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27408771%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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