(Q35180070)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Erik Gylfe

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Katsuya Dezaki

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Boldbaatar Damdindorj

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Oleg Dyachok

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Anders Tengholm

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Tomoyuki Kurashina

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Masashi Yoshida

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Masafumi Kakei

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Toshihiko Yada

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

language of work or name

English

0 references

publication date

25 July 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

60

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

2315-2324

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

8 February 2020

copyright license

start time

27 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteins

1 reference

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Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor

13 July 2018

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Modulation of ghrelin O-acyltransferase expression in pancreatic islets.

13 July 2018

1 reference

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Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans

13 July 2018

1 reference

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PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans

13 July 2018

1 reference

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Ghrelin octanoylation mediated by an orphan lipid transferase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis

13 July 2018

1 reference

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Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Drug insight: The functions of ghrelin and its potential as a multitherapeutic hormone

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

A new hypoglycemic agent, JTT-608, evokes protein kinase A-mediated Ca(2+) signaling in rat islet beta-cells: strict regulation by glucose, link to insulin release, and cooperation with glucagon-like peptide-1(7-36)amide and pituitary adenylate [...]

13 July 2018

1 reference

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Triggering and amplifying pathways of regulation of insulin secretion by glucose

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

13 July 2018

1 reference

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Ghrelin is a growth-hormone-releasing acylated peptide from stomach

13 July 2018

1 reference

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13 July 2018

Glucagon-like peptides

1 reference

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Mechanisms of inhibition of insulin release

13 July 2018

1 reference

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Signaling mechanisms underlying the insulinotropic effect of pituitary adenylate cyclase-activating polypeptide in HIT-T15 cells

13 July 2018

1 reference

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A receptor in pituitary and hypothalamus that functions in growth hormone release

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Two distinct modes of Ca2+ signalling by ACh in rat pancreatic beta-cells: concentration, glucose dependence and Ca2+ origin

13 July 2018

1 reference

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Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor

13 July 2018

1 reference

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A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Galanin activates nucleotide-dependent K+ channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Effects of cAMP-binding site mutations on intradomain cross-communication in the regulatory subunit of cAMP-dependent protein kinase I.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Ghrelin signalling in guinea-pig femoral artery smooth muscle cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Distribution and regulation of chicken growth hormone secretagogue receptor isoforms.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Intracellular signaling mechanisms mediating ghrelin-stimulated growth hormone release in somatotropes.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Stimulatory effect of ghrelin on isolated porcine somatotropes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Dose-dependent inhibition by ghrelin of insulin secretion in the mouse

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

Imaging of cAMP-dependent protein kinase activity in living neural cells using a novel fluorescent substrate.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161328

The muscarinic receptor subtype in mouse pancreatic B-cells

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21788571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Relative importance of extracellular and intracellular Ca2+ for acetylcholine stimulation of insulin release in mouse islets

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21788571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Morphological analysis of ghrelin and its receptor distribution in the rat pancreas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21788571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB11-0368

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21788571%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

21788571

1 reference