(Q40625087)

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Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

scientific article published on 16 October 2003

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20 December 2019

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways (English)

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20 December 2019

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ChEBI release 2020-05-28

Michael B. Wheeler

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20 December 2019

Patrick E. Macdonald

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20 December 2019

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Xiaolin Wang

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20 December 2019

Fuzhen Xia

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20 December 2019

Wasim El-kholy

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20 December 2019

Elisha D Targonsky

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20 December 2019

Robert G Tsushima

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20 December 2019

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16 October 2003

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20 December 2019

Journal of Biological Chemistry

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20 December 2019

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20 December 2019

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20 December 2019

52446-52453

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20 December 2019

Central motor conduction time in children and adolescents with insulin-dependent diabetes mellitus (IDDM)

1 reference

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21 January 2018

Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

1 reference

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21 January 2018

Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion

1 reference

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21 January 2018

Tetraethylammonium potentiation of insulin release and inhibition of rubidium efflux in pancreatic islets

1 reference

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21 January 2018

The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion

1 reference

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21 January 2018

An alternate pathway of cAMP-stimulated Cl secretion across the NKCC1-null murine duodenum

1 reference

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21 January 2018

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

1 reference

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21 January 2018

cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects

1 reference

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21 January 2018

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

1 reference

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21 January 2018

Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic beta-cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

1 reference

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21 January 2018

Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2

1 reference

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21 January 2018

Modulation of an inactivating human cardiac K+ channel by protein kinase C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Structure and function of phosphoinositide 3-kinases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Beta-adrenergic modulation of K+ current in human T lymphocytes

1 reference

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21 January 2018

Beta-adrenergic modulation of cardiac ion channels. Differential temperature sensitivity of potassium and calcium currents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Cyclic AMP-modulated potassium channels in murine B cells and their precursors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307612200

21 January 2018

Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.

1 reference

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21 January 2018

Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport.

1 reference

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21 January 2018

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M307612200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14565957%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14565957%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

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