(Q37048314)

17 August 2017

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title

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics (English)

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17 August 2017

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3

Mark T Gladwin

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17 August 2017

Jon O Lundberg

1

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PubMed ID

18167491

17 August 2017

Eddie Weitzberg

series ordinal

2

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17 August 2017

1 February 2008

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Nature Reviews Drug Discovery

17 August 2017

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17 August 2017

7

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17 August 2017

156-167

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17 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrd2466

17 August 2017

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Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

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Inorganic nitrate is a possible source for systemic generation of nitric oxide

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Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration

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Human xanthine oxidase converts nitrite ions into nitric oxide (NO)

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Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase

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Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions

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Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine

31 March 2020

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Apples increase nitric oxide production by human saliva at the acidic pH of the stomach: a new biological function for polyphenols with a catechol group?

31 March 2020

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Red wine-dependent reduction of nitrite to nitric oxide in the stomach

31 March 2020

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Decreased nitric-oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart

31 March 2020

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Diminished NO release in chronic hypoxic human endothelial cells

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Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

31 March 2020

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Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

31 March 2020

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Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues

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Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans

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Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo.

31 March 2020

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The L-arginine-nitric oxide pathway

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Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis

31 March 2020

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Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals

31 March 2020

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Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial L-arginine-NO pathway

31 March 2020

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Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues.

31 March 2020

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Effect of exercise training on endothelium-derived nitric oxide function in humans.

31 March 2020

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Exercise training increases basal nitric oxide production from the forearm in hypercholesterolemic patients.

31 March 2020

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Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans

31 March 2020

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Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease

31 March 2020

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Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans

31 March 2020

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31 March 2020

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Nitric oxide synthesis and metabolism in man.

31 March 2020

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Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds

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Nonenzymatic nitric oxide production in humans

31 March 2020

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Gastrointestinal nitric oxide generation in germ-free and conventional rats

31 March 2020

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Nitric Oxide Is Generated on the Skin Surface by Reduction of Sweat Nitrate

31 March 2020

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Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite

31 March 2020

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Urinary nitrite: more than a marker of infection

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Role of nitric oxide synthesis in macrophage antimicrobial activity

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Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide

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Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defense.

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Intragastric generation of antimicrobial nitrogen oxides from saliva--physiological and therapeutic considerations.

31 March 2020

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Nitrite in saliva increases gastric mucosal blood flow and mucus thickness.

31 March 2020

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Dietary nitrate increases gastric mucosal blood flow and mucosal defense

31 March 2020

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Intragastric CO2 and nitric oxide participate in the regulation of peptone-induced gastrin release in humans

31 March 2020

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THE NATURE OF CIRCULATORY COLLAPSE INDUCED BY SODIUM NITRITE.

31 March 2020

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Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action

31 March 2020

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Hemoglobin and the paracrine and endocrine functions of nitric oxide

31 March 2020

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Effects of dietary nitrate on blood pressure

31 March 2020

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Effects of dietary nitrate on blood pressure in healthy volunteers.

31 March 2020

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The reaction between nitrite and deoxyhemoglobin. Reassessment of reaction kinetics and stoichiometry.

31 March 2020

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Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control

31 March 2020

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Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin

31 March 2020

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Effects of dietary nitrate on oxygen cost during exercise

31 March 2020

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Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues

31 March 2020

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Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes

31 March 2020

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Nitrite reductase activity is a novel function of mammalian mitochondria

31 March 2020

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Various intracellular compartments cooperate in the release of nitric oxide from glycerol trinitrate in liver

31 March 2020

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Nitric oxide synthase reduces nitrite to NO under anoxia

31 March 2020

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Mechanisms of vasodilatation induced by nitrite instillation in intestinal lumen: possible role of hemoglobin

31 March 2020

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Nitrite is an alternative source of NO in vivo.

31 March 2020

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Malfunction of vascular control in lifestyle-related diseases: formation of systemic hemoglobin-nitric oxide complex (HbNO) from dietary nitrite

31 March 2020

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Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator

31 March 2020

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Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage

31 March 2020

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Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage

31 March 2020

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Low-dose intravenous nitrite improves hemodynamics in a canine model of acute pulmonary thromboembolism

31 March 2020

1 reference

Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development

31 March 2020

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

31 March 2020

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Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation

31 March 2020

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Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels

31 March 2020

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Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injury.

31 March 2020

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Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase

31 March 2020

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Cardioprotective effects of vegetables: is nitrate the answer?

31 March 2020

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Hypothesis: the effect of oral nitrite on blood pressure in the spontaneously hypertensive rat. Does dietary nitrate mitigate hypertension after conversion to nitrite?

31 March 2020

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Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.

31 March 2020

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Mitochondrial K(ATP) channels in preconditioning

31 March 2020

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Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection

31 March 2020

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Exogenous nitric oxide generates ROS and induces cardioprotection: involvement of PKG, mitochondrial KATP channels, and ERK.

31 March 2020

1 reference

Cellular, biochemical, and molecular aspects of reperfusion injury. Introduction

31 March 2020

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Direct measurement of free radical generation following reperfusion of ischemic myocardium

31 March 2020

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Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.

31 March 2020

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Direct evidence for S-nitrosation of mitochondrial complex I.

31 March 2020

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Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria

31 March 2020

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Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases

31 March 2020

1 reference

Nitric oxide formed by nitrite reductase of Paracoccus denitrificans is sufficiently stable to inhibit cytochrome oxidase activity and is reduced by its reductase under aerobic conditions

31 March 2020

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Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

31 March 2020

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Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes

31 March 2020

1 reference

Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury

31 March 2020

1 reference

Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds

31 March 2020

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Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury.

31 March 2020

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Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion.

31 March 2020

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Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation

31 March 2020

1 reference

Early inhaled nitric oxide therapy in premature newborns with respiratory failure

31 March 2020

1 reference

Nonsteroidal anti-inflammatory drug gastropathy

31 March 2020

1 reference

Nitric oxide in mucosal defense: a little goes a long way.

31 March 2020

1 reference

Role of bacteria and inducible nitric oxide synthase activity in the systemic inflammatory microvascular response provoked by indomethacin in the rat.

31 March 2020

1 reference

Non-steroidal anti-inflammatory drugs: overall risks and management. Complementary roles for COX-2 inhibitors and proton pump inhibitors

31 March 2020

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Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate

31 March 2020

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Dietary nitrate inhibits stress-induced gastric mucosal injury in the rat.

31 March 2020

1 reference

Helicobacter pylori is killed by nitrite under acidic conditions

31 March 2020

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Intragastric nitric oxide is abolished in intubated patients and restored by nitrite

31 March 2020

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Nitrite Inhibition of Clostridium botulinum : Electron Spin Resonance Detection of Iron-Nitric Oxide Complexes

31 March 2020

1 reference

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions.

31 March 2020

1 reference

In vitro evaluation of a new treatment for urinary tract infections caused by nitrate-reducing bacteria

31 March 2020

1 reference

A randomized trial of acidified nitrite cream in the treatment of tinea pedis

31 March 2020

1 reference

Antimicrobial effect of acidified nitrite on dermatophyte fungi, Candida and bacterial skin pathogens

31 March 2020

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Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream

31 March 2020

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Intravesical nitric oxide delivery for prevention of catheter-associated urinary tract infections

31 March 2020

1 reference

Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics

31 March 2020

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Protective effect of dietary nitrate on experimental gastritis in rats

31 March 2020

1 reference

Potential cardioprotective actions of no-releasing aspirin

31 March 2020

1 reference

Allylic nitro compounds as nitrite donors

31 March 2020

1 reference

Cured meat consumption, lung function, and chronic obstructive pulmonary disease among United States adults

31 March 2020

1 reference

Workgroup report: Drinking-water nitrate and health--recent findings and research needs

31 March 2020

1 reference

The effect of fruit and vegetable intake on risk for coronary heart disease

31 March 2020

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Optimal diets for prevention of coronary heart disease

31 March 2020

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A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD2466

1 reference

17 August 2017

1 reference

PubMed ID

18167491