(Q37050322)

17 August 2017

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title

Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases (English)

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17 August 2017

Mariana Hainrichson

1

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17 August 2017

Igor Nudelman

series ordinal

2

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17 August 2017

Timor Baasov

series ordinal

3

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17 August 2017

publication date

9 October 2007

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Organic and Biomolecular Chemistry

17 August 2017

published in

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17 August 2017

volume

6

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17 August 2017

issue

2

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17 August 2017

page(s)

227-239

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RNA as a Drug Target: The Case of Aminoglycosides

17 August 2017

cites work

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Versatility of aminoglycosides and prospects for their future

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Molecular insights into aminoglycoside action and resistance

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Drugs targeting the ribosome

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New insights into aminoglycoside antibiotics and derivatives.

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Structural basis for selectivity and toxicity of ribosomal antibiotics

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Molecular understanding of aminoglycoside action and resistance

21 January 2018

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The treatment of respiratory pseudomonas infection in cystic fibrosis: what drug and which way?

21 January 2018

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Interaction of antibiotics with functional sites in 16S ribosomal RNA

21 January 2018

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Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

21 January 2018

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Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution

21 January 2018

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Paromomycin binding induces a local conformational change in the A-site of 16 S rRNA

21 January 2018

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Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: an analysis of x-ray crystal structures

21 January 2018

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Structure of the 30S ribosomal subunit

21 January 2018

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Recognition of cognate transfer RNA by the 30S ribosomal subunit

21 January 2018

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Selection of tRNA by the ribosome requires a transition from an open to a closed form

21 January 2018

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Structural insights into translational fidelity

21 January 2018

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Effects of Apramycin, a Novel Aminoglycoside Antibiotic on Bacterial Protein Synthesis

21 January 2018

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Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex

21 January 2018

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Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity.

21 January 2018

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Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa

21 January 2018

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Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance

21 January 2018

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Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase

21 January 2018

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Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry

21 January 2018

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The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance

21 January 2018

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Overexpression and initial characterization of the chromosomal aminoglycoside 3'-O-phosphotransferase APH(3')-IIb from Pseudomonas aeruginosa

21 January 2018

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Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci

21 January 2018

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Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6')-APH(2'').

21 January 2018

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Aminoglycoside antibiotics

21 January 2018

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Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity

21 January 2018

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Defining the basis for the specificity of aminoglycoside-rRNA recognition: a comparative study of drug binding to the A sites of Escherichia coli and human rRNA.

21 January 2018

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Melatonin protects against gentamicin-induced nephrotoxicity in rats

21 January 2018

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Antioxidant gene therapy can protect hearing and hair cells from ototoxicity

21 January 2018

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Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists

21 January 2018

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Aminoglycoside nephrotoxicity: do time and frequency of administration matter?

21 January 2018

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A non-nephrotoxic gentamicin congener that retains antimicrobial efficacy.

21 January 2018

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21 January 2018

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Tuning the regioselectivity of the Staudinger reaction for the facile synthesis of kanamycin and neomycin class antibiotics with N-1 modification.

21 January 2018

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Investigation of the regioselectivity for the staudinger reaction and its application for the synthesis of aminoglycosides with N-1 modification.

21 January 2018

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Design of novel antibiotics that bind to the ribosomal acyltransfer site

21 January 2018

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The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography

21 January 2018

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Branched aminoglycosides: biochemical studies and antibacterial activity of neomycin B derivatives

21 January 2018

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Dual effect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor

21 January 2018

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Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site

21 January 2018

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Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.

21 January 2018

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Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system

21 January 2018

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Pharmacologic therapy for stop mutations: how much CFTR activity is enough?

21 January 2018

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Mutations to nonsense codons in human genetic disease: implications for gene therapy by nonsense suppressor tRNAs

21 January 2018

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Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin

21 January 2018

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Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line

21 January 2018

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Gentamicin-Induced Correction of CFTR Function in Patients with Cystic Fibrosis andCFTRStop Mutations

21 January 2018

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Gentamicin-mediated suppression of Hurler syndrome stop mutations restores a low level of alpha-L-iduronidase activity and reduces lysosomal glycosaminoglycan accumulation

21 January 2018

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Aminoglycoside-mediated rescue of a disease-causing nonsense mutation in the V2 vasopressin receptor gene in vitro and in vivo

21 January 2018

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Expression of CTNS alleles: subcellular localization and aminoglycoside correction in vitro

21 January 2018

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In vitro analysis of aminoglycoside therapy for the Arg120stop nonsense mutation in RP2 patients

21 January 2018

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Enhanced production of functional proteins from defective genes

21 January 2018

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Readthrough of dystrophin stop codon mutations induced by aminoglycosides

21 January 2018

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The Molecular Basis for A‐Site Mutations Conferring Aminoglycoside Resistance: Relationship between Ribosomal Susceptibility and X‐ray Crystal Structures

21 January 2018

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Basis for prokaryotic specificity of action of aminoglycoside antibiotics

21 January 2018

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Novel aminoglycosides increase SMN levels in spinal muscular atrophy fibroblasts

21 January 2018

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Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site

21 January 2018

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Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites

21 January 2018

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Apramycin recognition by the human ribosomal decoding site

21 January 2018

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Fluorescence-based approach for detecting and characterizing antibiotic-induced conformational changes in ribosomal RNA: comparing aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA sequences.

21 January 2018

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Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies

21 January 2018

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Comparison of cytotoxicity of aminoglycoside antibiotics using a panel cellular biotest system

21 January 2018

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In vitro and ex vivo suppression by aminoglycosides of PCDH15 nonsense mutations underlying type 1 Usher syndrome

21 January 2018

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PTC124 targets genetic disorders caused by nonsense mutations

21 January 2018

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When running a stop sign may be a good thing

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B712690P

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17 August 2017

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