(Q37052955)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

main subject

squamous cell carcinoma

1 reference

Catherine Wilson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Benjamin Ory

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

S Michael Rothenberg

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

William Faquin

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Alea A Mills

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

language of work or name

English

0 references

publication date

8 July 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

5 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

volume

123

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

page(s)

3525-3538

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

5 March 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3726171

inferred from PubMed Central ID database lookup

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PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

29 September 2017

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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

29 September 2017

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The mutational landscape of head and neck squamous cell carcinoma

29 September 2017

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Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells

29 September 2017

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Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer

29 September 2017

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Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma

29 September 2017

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A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma.

29 September 2017

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Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.

29 September 2017

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ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

29 September 2017

1 reference

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TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

29 September 2017

1 reference

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Fibroblast growth factor signalling: from development to cancer

29 September 2017

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Cancer associated fibroblasts in cancer pathogenesis

29 September 2017

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PTEN: new insights into its regulation and function in skin cancer

29 September 2017

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(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

29 September 2017

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A two-step mechanism for stem cell activation during hair regeneration

29 September 2017

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Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells

29 September 2017

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Drug-sensitive FGFR2 mutations in endometrial carcinoma

29 September 2017

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29 September 2017

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Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering

29 September 2017

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Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice

29 September 2017

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TP53 mutations and survival in squamous-cell carcinoma of the head and neck.

29 September 2017

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p63 and p73 in human cancer: defining the network

29 September 2017

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p63 regulates an adhesion programme and cell survival in epithelial cells

29 September 2017

1 reference

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Linear models and empirical bayes methods for assessing differential expression in microarray experiments

29 September 2017

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Gefitinib (ZD1839, Iressa) as palliative treatment in recurrent or metastatic head and neck cancer

29 September 2017

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p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

29 September 2017

1 reference

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p63 deficiency activates a program of cellular senescence and leads to accelerated aging

29 September 2017

1 reference

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High-resolution genomic profiles of human lung cancer

29 September 2017

1 reference

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p63 is the molecular switch for initiation of an epithelial stratification program

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Gefitinib ('Iressa', ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, up-regulates p27KIP1 and induces G1 arrest in oral squamous cell carcinoma cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck

29 September 2017

1 reference

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DAVID: Database for Annotation, Visualization, and Integrated Discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Loss of p63 expression is associated with tumor progression in bladder cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Transcription factors as targets for cancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

AIS is an oncogene amplified in squamous cell carcinoma

29 September 2017

1 reference

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The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin

29 September 2017

1 reference

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p63 is a p53 homologue required for limb and epidermal morphogenesis

29 September 2017

1 reference

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Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon

29 September 2017

1 reference

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Receptor specificity of the fibroblast growth factor family

29 September 2017

1 reference

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Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Tumor spectrum analysis in p53-mutant mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Association of p63 with proliferative potential in normal and neoplastic human keratinocytes

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

A new human cell line (FaDu) from a hypopharyngeal carcinoma.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Two new human tumor cell lines derived from squamous cell carcinomas of the tongue: establishment, characterization and response to cytotoxic treatment.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Characterization of 21 newly established esophageal cancer cell lines

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Fibrous stroma is associated with poorer prognosis in lung squamous cell carcinoma patients

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Collective invasion of carcinoma cells: when the fibroblasts take the lead

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Perp is a p63-regulated gene essential for epithelial integrity.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Dominant negative p63 isoform expression in head and neck squamous cell carcinoma

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Papillomas induced by initiation-promotion differ from those induced by carcinogen alone.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726171

Cancer-associated fibroblasts and CD163-positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance

4 September 2018

1 reference

12 December 2020

Conditional inactivation of p63 by Cre-mediated excision

1 reference

12 December 2020

Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling

1 reference

12 December 2020

Expression of bFGF, KGF and FGF receptors on normal oral mucosa and SCC

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI68899

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23867503%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

23867503

1 reference