(Q37054521)

18 August 2017

S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase (English)

1 reference

18 August 2017

3

Ivan Rosenberg

0 references

author name string

Jiri Jiracek

1

1 reference

18 August 2017

Michaela Collinsova

2

1 reference

18 August 2017

Ivan Rosenberg

3

1 reference

18 August 2017

Milos Budesinsky

4

1 reference

18 August 2017

Eva Protivinska

5

1 reference

18 August 2017

Hana Netusilova

6

1 reference

18 August 2017

Timothy A Garrow

7

1 reference

18 August 2017

language of work or name

English

0 references

publication date

1 June 2006

1 reference

Journal of Medicinal Chemistry

18 August 2017

1 reference

18 August 2017

49

1 reference

18 August 2017

13

1 reference

18 August 2017

3982-3989

1 reference

Methionine dependence of tumours: a biochemical strategy for optimizing paclitaxel chemosensitivity in vitro.

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Osmotic regulation of renal betaine transport: transcription and beyond

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Neural control of hepatic osmolytes and parenchymal cell hydration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Crystal structure of rat liver betaine homocysteine s-methyltransferase reveals new oligomerization features and conformational changes upon substrate binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Betaine-homocysteine methyltransferase: zinc in a distorted barrel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

S-Adenosylmethionine: a control switch that regulates liver function.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

2'C-alkoxy and 2'-C-aryloxy derivatives of N-(2-phosphonomethoxyethyl)-purines and -pyrimidines: synthesis and biological activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Homocysteine and cardiovascular disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Folate, vitamin B12, and neuropsychiatric disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

N-dibenzylphospho-N'-3-(2,6-dichlorophenyl)propyl-guanidine is a bisubstrate-analog for creatine kinase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Evidence for direct methyl transfer in betaine: homocysteine S-methyl-transferase

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

The graphical determination of Km and Ki

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Design and synthesis of phosphonate inhibitors of glutamine synthetase.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Oligomerization is required for betaine-homocysteine S-methyltransferase function

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Physicochemical characterization of phosphinic pseudopeptides by capillary zone electrophoresis in highly acidic background electrolytes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Human betaine-homocysteine methyltransferase is a zinc metalloenzyme

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Hyperhomocysteinemia, a risk factor for atherosclerosis in chronic uremic patients.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2622432

Betaine as an osmolyte in rat liver: metabolism and cell-to-cell interactions

4 September 2018

1 reference

12 December 2020

Determination of dissociation constant of phosphinate group in phosphinic pseudopeptides by capillary zone electrophoresis

1 reference

12 December 2020

Analysis and characterization of phosphinic pseudopeptides by capillary zone electrophoresis

1 reference

12 December 2020

Recombinant human liver betaine-homocysteine S-methyltransferase: identification of three cysteine residues critical for zinc binding

1 reference

12 December 2020

Promotion of intestinal carcinogenesis by dietary methionine

1 reference

12 December 2020

Methionine metabolism in mammals: Kinetic study of betaine-homocysteine methyltransferase

1 reference

12 December 2020

Methionine metabolism in mammals. Distribution of homocysteine between competing pathways

1 reference

12 December 2020

Betaine:homocysteine methyltransferase from rat liver: purification and inhibition by a boronic acid substrate analog

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM050885V

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

16789755

1 reference