(Q37064937)

18 August 2017

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title

Rational design of competitive prolactin/growth hormone receptor antagonists (English)

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18 August 2017

Estelle Tallet

1

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18 August 2017

Vincent Rouet

2

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18 August 2017

Jean-Baptiste Jomain

3

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18 August 2017

Paul A Kelly

4

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18 August 2017

Sophie Bernichtein

5

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18 August 2017

Vincent Goffin

6

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18 August 2017

publication date

25 January 2008

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Journal of Mammary Gland Biology and Neoplasia

18 August 2017

published in

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18 August 2017

volume

13

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18 August 2017

issue

1

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18 August 2017

page(s)

105-117

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Medical management of prolactin-secreting pituitary adenomas

18 August 2017

cites work

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12 December 2020

A human prolactin antagonist, hPRL-G129R, inhibits breast cancer cell proliferation through induction of apoptosis.

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12 December 2020

Prolactin as an autocrine/paracrine growth factor in human cancer.

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12 December 2020

Rational design of potent antagonists to the human growth hormone receptor

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12 December 2020

The role of prolactin in mammary carcinoma

1 reference

12 December 2020

Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL

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12 December 2020

The N-terminus of human prolactin modulates its biological properties

1 reference

12 December 2020

Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly.

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12 December 2020

Prolactin involvement in breast cancer

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12 December 2020

Increased expression of prolactin receptor gene assessed by quantitative polymerase chain reaction in human breast tumors versus normal breast tissues

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12 December 2020

Cellular expression of growth hormone and prolactin receptors in human breast disorders

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12 December 2020

Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade

1 reference

12 December 2020

Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone

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12 December 2020

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

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12 December 2020

Expression of a mutated bovine growth hormone gene suppresses growth of transgenic mice

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12 December 2020

Autocrine stimulation of human mammary carcinoma cell proliferation by human growth hormone

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12 December 2020

Prolactin as a Chemoattractant for Human Breast Carcinoma

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12 December 2020

Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse

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12 December 2020

Prolactin and murine mammary tumorigenesis: a review

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12 December 2020

In vivo studies of the anti-tumor effects of a human prolactin antagonist, hPRL-G129R.

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12 December 2020

Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer

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12 December 2020

Regulation of bcl-2 gene expression in human breast cancer cells by prolactin and its antagonist, hPRL-G129R

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12 December 2020

The effects of autocrine human growth hormone (hGH) on human mammary carcinoma cell behavior are mediated via the hGH receptor

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12 December 2020

Unmodified prolactin (PRL) and S179D PRL-initiated bioluminescence resonance energy transfer between homo- and hetero-pairs of long and short human PRL receptors in living human cells

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12 December 2020

Glycine 119 of bovine growth hormone is critical for growth-promoting activity

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12 December 2020

Hematopoietic receptor complexes

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12 December 2020

Drug Insight: prolactin-receptor antagonists, a novel approach to treatment of unresolved systemic and local hyperprolactinemia?

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12 December 2020

In vitro and in vivo studies of antagonistic effects of human growth hormone analogs.

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12 December 2020

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

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12 December 2020

Prolactin-regulated tyrosine hydroxylase activity and messenger ribonucleic acid expression in mediobasal hypothalamic cultures: the differential role of specific protein kinases

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12 December 2020

Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling.

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12 December 2020

The human growth hormone antagonist B2036 does not interact with the prolactin receptor

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12 December 2020

Dopamine as a Prolactin (PRL) Inhibitor

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12 December 2020

Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects

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12 December 2020

A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer

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12 December 2020

Development of pure prolactin receptor antagonists.

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12 December 2020

Tamoxifen plus bromocriptine versus tamoxifen plus placebo in advanced breast cancer: results of a double blind multicentre clinical trial

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12 December 2020

Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions.

1 reference

12 December 2020

Growth hormone (GH) and a GH antagonist promote GH receptor dimerization and internalization

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12 December 2020

Prospective randomized trial concerning hyper- and normoprolactinemia and the use of bromoergocryptine in patients with metastatic breast cancer

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12 December 2020

Involvement of prolactin in breast cancer: redefining the molecular targets.

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12 December 2020

The growth hormone/prolactin receptor gene family

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12 December 2020

Additive effects of a prolactin receptor antagonist, G129R, and herceptin on inhibition of HER2-overexpressing breast cancer cells.

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12 December 2020

Transcription of the human prolactin gene in mammary cells

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12 December 2020

Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice

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12 December 2020

Solution Structure of Human Prolactin

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12 December 2020

Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling

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12 December 2020

S179D-human PRL, a pseudophosphorylated human PRL analog, is an agonist and not an antagonist

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12 December 2020

Prolactin modulates TRPV1 in female rat trigeminal sensory neurons

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12 December 2020

Evidence for a second receptor binding site on human prolactin.

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12 December 2020

A phase II study of bromocriptine in patients with androgen-independent prostate cancer.

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12 December 2020

Endocrine pharmacology of antiestrogens as antitumor agents

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12 December 2020

Signal transducer and activator of transcription-5 activation and breast cancer prognosis

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12 December 2020

Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications.

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12 December 2020

Human prolactin and its antagonist, hPRL-G129R, regulate bax and bcl-2 gene expression in human breast cancer cells and transgenic mice.

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12 December 2020

The role of prolactin and growth hormone in mammary gland development

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12 December 2020

Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it binds to a receptor dimer

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12 December 2020

Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.

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12 December 2020

Prolactin expression and secretion by human breast glandular and adipose tissue explants

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12 December 2020

Ligand-independent homo- and heterodimerization of human prolactin receptor variants: inhibitory action of the short forms by heterodimerization.

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12 December 2020

In vitro studies of a prolactin antagonist, hPRL-G129R in human breast cancer cells

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12 December 2020

The role of human prolactin and its antagonist, G129R, in mammary gland development and DMBA-initiated tumorigenesis in transgenic mice.

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12 December 2020

Interleukin-2 and its receptor complex (alpha, beta and gamma chains) in in situ and infiltrative human breast cancer: an immunohistochemical comparative study

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12 December 2020

Mechanism-based design of prolactin receptor antagonists.

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12 December 2020

New homologous bioassays for human lactogens show that agonism or antagonism of various analogs is a function of assay sensitivity

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12 December 2020

Development and potential clinical uses of human prolactin receptor antagonists

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12 December 2020

Pituitary tumors: pathophysiology, clinical manifestations and management

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12 December 2020

Transcriptional regulation by the helix bundle peptide hormones: growth hormone, prolactin, and hematopoietic cytokines

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12 December 2020

Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization

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12 December 2020

Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor

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12 December 2020

Biological properties of human prolactin analogs depend not only on global hormone affinity, but also on the relative affinities of both receptor binding sites

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12 December 2020

Autocrine human growth hormone (hGH) regulation of human mammary carcinoma cell gene expression. Identification of CHOP as a mediator of hGH-stimulated human mammary carcinoma cell survival.

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12 December 2020

The human growth hormone (hGH) antagonist G120RhGH does not antagonize GH in the rat, but has paradoxical agonist activity, probably via the prolactin receptor

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12 December 2020

Mechanism for ordered receptor binding by human prolactin

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12 December 2020

Defining the role of prolactin as an invasion suppressor hormone in breast cancer cells.

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12 December 2020

Prolactin antagonist-endostatin fusion protein as a targeted dual-functional therapeutic agent for breast cancer

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12 December 2020

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

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12 December 2020

Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals

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12 December 2020

Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells.

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12 December 2020

Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin.

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12 December 2020

Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway

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12 December 2020

Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines

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12 December 2020

New insights into growth hormone action.

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12 December 2020

Beyond Herceptin and Gleevec

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12 December 2020

Dimerization and signal transduction of the growth hormone receptor

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12 December 2020

Advanced rat mammary cancers are growth hormone dependent

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12 December 2020

Expression by Transgenesis of a Constitutively Active Mutant Form of the Prolactin Receptor Induces Premature Abnormal Development of the Mouse Mammary Gland and Lactation Failure1

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12 December 2020

Cloning and expression of the rat prolactin receptor, a member of the growth hormone/prolactin receptor gene family

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12 December 2020

Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma.

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12 December 2020

EGF stimulates Pit-1 independent transcription of the human prolactin pituitary promoter in human breast cancer SK-BR-3 cells through its proximal AP-1 response element

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12 December 2020

Human prolactin (hPRL) antagonists inhibit hPRL-activated signaling pathways involved in breast cancer cell proliferation

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12 December 2020

Nuclear localization and function of polypeptide ligands and their receptors: a new paradigm for hormone specificity within the mammary gland?

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12 December 2020

A novel design of targeted endocrine and cytokine therapy for breast cancer.

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12 December 2020

Does growth hormone drive breast and other cancers?

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12 December 2020

Advances in the treatment of prolactinomas

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12 December 2020

The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth

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12 December 2020

10.1007/S10911-008-9066-8

Identifiers

DOI

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18 August 2017

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