(Q37068538)

18 August 2017

1 reference

title

Mechanisms of cigarette smoke-induced COPD: insights from animal models (English)

1 reference

18 August 2017

Andrew Churg

1

1 reference

18 August 2017

Manuel Cosio

series ordinal

2

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18 August 2017

Joanne L Wright

series ordinal

3

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18 August 2017

publication date

25 January 2008

1 reference

American Journal of Physiology - Lung Cellular and Molecular Physiology

18 August 2017

published in

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18 August 2017

volume

294

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18 August 2017

issue

4

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18 August 2017

page(s)

L612-31

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A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis

18 August 2017

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Effects of all-trans-retinoic acid in promoting alveolar repair

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The role of oxidative stress in chronic obstructive pulmonary disease

21 January 2018

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Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice.

21 January 2018

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Cor pulmonale: an overview

21 January 2018

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Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema

21 January 2018

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Exacerbations of chronic obstructive pulmonary disease

21 January 2018

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Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown

21 January 2018

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Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice

21 January 2018

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α-1-Antitrypsin Ameliorates Cigarette Smoke–induced Emphysema in the Mouse

21 January 2018

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Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse

21 January 2018

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Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall

21 January 2018

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Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs

21 January 2018

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Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages.

21 January 2018

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Elevated pulmonary artery pressure. An independent predictor of mortality.

21 January 2018

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Inflammation of the airways and lung parenchyma in COPD: role of T cells

21 January 2018

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Immunolocalization of elastase in human emphysematous lungs

21 January 2018

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Molecular mechanisms in chronic obstructive pulmonary disease: potential targets for therapy

21 January 2018

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Perspectives for cytokine antagonist therapy in COPD.

21 January 2018

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Elevated MMP-12 protein levels in induced sputum from patients with COPD.

21 January 2018

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Genetic determinants of emphysema distribution in the national emphysema treatment trial

21 January 2018

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Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?

21 January 2018

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Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema.

21 January 2018

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Cellularity of the alveolar walls in smokers and its relation to alveolar destruction. Functional implications

21 January 2018

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Structural emphysema does not correlate with lung compliance: lessons from the mouse smoking model.

21 January 2018

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Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice.

21 January 2018

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Transcriptional and posttranscriptional inhibition of lysyl oxidase expression by cigarette smoke condensate in cultured rat fetal lung fibroblasts

21 January 2018

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Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

The development of emphysema in cigarette smoke-exposed mice is strain dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Global burden of COPD: systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

The matrix degrades, neutrophils invade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

The nature of small-airway obstruction in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Elastin fragments drive disease progression in a murine model of emphysema

21 January 2018

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Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease

21 January 2018

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Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema

21 January 2018

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Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

21 January 2018

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Cor Pulmonale: Correlation with Central Airway Lesions, Peripheral Airway Lesions, Emphysema, and Control of Breathing

21 January 2018

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Remodeling in asthma and chronic obstructive lung disease

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Gene-environment interactions in asthma and other respiratory diseases

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Cytokine and chemokine expression in cigarette smoke-induced lung injury in guinea pigs.

21 January 2018

1 reference

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The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency

21 January 2018

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Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Antielastin autoimmunity in tobacco smoking-induced emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

The inhibitory effects of rebamipide on cigarette smoke-induced airway mucin production

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease. Part One.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease. Part two.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Animal models of pulmonary emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 strain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Structure of central airways in current smokers and ex-smokers with and without mucus hypersecretion: relationship to lung function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8 mRNA expression in guinea pigs in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Different proliferative capacity of lung fibroblasts obtained from control subjects and patients with emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Cigarette smoke induces cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Lung particle overload: implications for occupational exposures to particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Matrix metalloproteinases as modulators of inflammation and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Burden and clinical features of chronic obstructive pulmonary disease (COPD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Inhaled recombinant alpha 1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Collagen-and collagen peptide-induced chemotaxis of human blood monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite

21 January 2018

1 reference

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Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Proteinase-activated receptor-1 regulation of macrophage elastase (MMP-12) secretion by serine proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Amplification of inflammation in emphysema and its association with latent adenoviral infection

21 January 2018

1 reference

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Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells.

21 January 2018

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Respiratory tract mucin genes and mucin glycoproteins in health and disease

21 January 2018

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Feasibility of retinoids for the treatment of emphysema study.

21 January 2018

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Oral N-acetylcysteine attenuates elastase-induced pulmonary emphysema in rats

21 January 2018

1 reference

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Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Genetic risk factors for chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Hemodynamic characterization of patients with severe emphysema.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Matrix Metalloproteinases Inhibition Attenuates Tobacco Smoke-Induced Emphysema in Guinea Pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Chemotactic activity of elastin-derived peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Non-small cell lung cancer in very young and very old patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Alpha1-antitrypsin determines the pattern of emphysema and function in tobacco smoke-exposed mice: parallels with human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Inflammatory cells and chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Role of CXCR2 in cigarette smoke-induced lung inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.

21 January 2018

1 reference

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Apoptosis and emphysema: the missing link.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Role of lung maintenance program in the heterogeneity of lung destruction in emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Cigarette smoke-induced emphysema: A role for the B cell?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

First study of infliximab treatment in patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Regulation of mucin genes in chronic inflammatory airway diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Inhalation toxicity studies on cigarette smoke (VII). 6-week comparative experiments using modified flue-cured cigarettes: histopathology of the conducting airways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Genetic polymorphisms of matrix metalloproteinases: functional importance in the development of chronic obstructive pulmonary disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Transforming growth factor-beta1 drives airway remodeling in cigarette smoke-exposed tracheal explants

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Distribution of tracheal and laryngeal mucous glands in some rodents and the rabbit

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

A distinctive alveolar macrophage activation state induced by cigarette smoking

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Effect of long-term exposure to cigarette smoke on the small airways of the guinea pig

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00390.2007

Identification of multiple MAPK-mediated transcription factors regulated by tobacco smoke in airway epithelial cells

21 January 2018

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Airway Remodeling in the Smoke Exposed Guinea Pig Model

21 January 2018

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21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference