(Q37069323)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18845240%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability (English)

1 reference

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15 January 2020

4

1 reference

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15 January 2020

Douglas R Spitz

5

1 reference

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15 January 2020

7

David J Grdina

1 reference

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15 January 2020

author name string

Jaroslaw Dziegielewski

1

1 reference

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15 January 2020

Janet E Baulch

2

1 reference

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15 January 2020

Wilfried Goetz

3

1 reference

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15 January 2020

Jeffrey S Murley

6

1 reference

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15 January 2020

William F Morgan

8

1 reference

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15 January 2020

publication date

18 September 2008

1 reference

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Free Radical Biology and Medicine

15 January 2020

published in

1 reference

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15 January 2020

volume

45

1 reference

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15 January 2020

issue

12

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15 January 2020

page(s)

1674-1681

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18845240%20AND%20SRC:MED&resulttype=core&format=json

Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine

15 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

mBAND analysis of chromosomal aberrations in human epithelial cells exposed to low- and high-LET radiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

DNA fragmentation induced in human fibroblasts by accelerated (56)fe ions of differing energies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Mechanism of the tumor suppressive effect of MnSOD overexpression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Role of cytokines and growth factors in radioprotection.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Ionizing radiation induces delayed hyperrecombination in Mammalian cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Genomic instability and bystander effects induced by high-LET radiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Protection against ionizing radiation by antioxidant nutrients and phytochemicals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander EffectsIn Vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Genomic instability induced by high and low LET ionizing radiation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

The in vitro micronucleus technique

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Apoptosis, reproductive failure, and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Pharmacologic approaches to protection against radiation-induced lethality and other damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Mammalian cell polyamine homeostasis is altered by the radioprotector WR1065.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

2-[(Aminopropyl)amino]ethanethiol (WR1065) is anti-neoplastic and anti-mutagenic when given during 60Co gamma-ray irradiation.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

In vivo protection by the aminothiol WR-2721 against neutron-induced carcinogenesis

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Dietary resveratrol administration increases MnSOD expression and activity in mouse brain.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Detailed characterization of the 1087 MeV/nucleon iron-56 beam used for radiobiology at the alternating gradient synchrotron.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629584

Protection by WR1065 and WR151326 against fission-neutron-induced mutations at the HGPRT locus in V79 cells

4 September 2018

1 reference

12 December 2020

Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action

1 reference

12 December 2020

Antimutagenic effects of amifostine: clinical implications

1 reference

12 December 2020

In vitro antioxidant properties of amifostine (WR-2721, Ethyol)

1 reference

12 December 2020

Phase III randomized trial of amifostine as a radioprotector in head and neck cancer

1 reference

12 December 2020

Relative effectiveness of HZE iron-56 particles for the induction of cytogenetic damage in vivo

1 reference

12 December 2020

Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage

1 reference

12 December 2020

Effects of thiols on topoisomerase-II alpha activity and cell cycle progression

1 reference

12 December 2020

Radioprotectors: current status and new directions

1 reference

12 December 2020

10.1016/J.FREERADBIOMED.2008.09.004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18845240%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18845240%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

18845240

1 reference