(Q37070610)

18 August 2017

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome (English)

1 reference

18 August 2017

1 reference

1 reference

1 reference

1 reference

Emma Creagh

4

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Virginie Pétrilli

Virginie Pétrilli

9

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Ed C. Lavelle

Ed C Lavelle

12

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James Harris

James Harris

5

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Jürg Tschopp

10

Jurg Tschopp

1 reference

18 August 2017

11

Luke A J O'Neill

1 reference

18 August 2017

Fiona A Sharp

1

1 reference

18 August 2017

Darren Ruane

2

1 reference

18 August 2017

Benjamin Claass

3

1 reference

18 August 2017

Padma Malyala

6

1 reference

18 August 2017

Manomohan Singh

7

1 reference

18 August 2017

Derek T O'Hagan

8

1 reference

18 August 2017

language of work or name

English

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publication date

12 January 2009

1 reference

Proceedings of the National Academy of Sciences of the United States of America

18 August 2017

1 reference

18 August 2017

106

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18 August 2017

870-875

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18 August 2017

3

1 reference

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Active caspase-1 is a regulator of unconventional protein secretion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Bridging the knowledge gaps in vaccine design

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

How do adjuvants work? Important considerations for new generation adjuvants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

29 September 2017

The science of adjuvants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Cryopyrin activates the inflammasome in response to toxins and ATP

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Gout-associated uric acid crystals activate the NALP3 inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

NLRs join TLRs as innate sensors of pathogens

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Blocking IL-1 in systemic inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Recent advances in the discovery and delivery of vaccine adjuvants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

New insights into the mechanism of IL-1beta maturation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Natural adjuvants: endogenous activators of dendritic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Immunology: Toll-like receptors and antibody responses

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Anionic microparticles are a potent delivery system for recombinant antigens from Neisseria meningitidis serotype B.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630092

Toll-like receptors and antibody responses (Reply)

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0804897106

Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants

21 January 2018

1 reference

12 December 2020

Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release

1 reference

12 December 2020

Activation of dendritic cells and induction of CD4(+) T cell differentiation by aluminum-containing adjuvants

1 reference

12 December 2020

Mutations in cryopyrin: bypassing roadblocks in the caspase 1 inflammasome for interleukin-1beta secretion and disease activity

1 reference

12 December 2020

Alum adjuvanticity: unraveling a century old mystery

1 reference

12 December 2020

Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome

1 reference

12 December 2020

Toll-like receptors control activation of adaptive immune responses

1 reference

12 December 2020

TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0804897106

1 reference

18 August 2017

0 references

1 reference

18 August 2017

1 reference